Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048449925> ?p ?o ?g. }
- W2048449925 endingPage "794" @default.
- W2048449925 startingPage "784" @default.
- W2048449925 abstract "The purpose of this manuscript is to review the results of studies on the recovery or plasticity following a denervation- or lesion-induced change in breathing. Carotid body denervation (CBD), lung denervation (LD), cervical (CDR) and thoracic (TDR) dorsal rhizotomy, dorsal spinal column lesions, and lesions at pontine, medullary, and spinal sites all chronically alter breathing. The plasticity after these is highly variable, ranging from near complete recovery of the peripheral chemoreflex in rats after CBD to minimal recovery of the Hering-Breuer inflation reflex in ponies after LD. The degree of plasticity varies among the different functions of each pathway, and plasticity varies with the age of the animal when the lesion was made. In addition, plasticity after some lesions varies between species, and plasticity is greater in the awake than in the anesthetized state. Reinnervation is not a common mechanism of plasticity. There is evidence supporting two mechanisms of plasticity. One is through upregulation of an alternate sensory pathway, such as serotonin-mediated aortic chemoreception after CBD. The second is through upregulation on the efferent limb of a reflex, such as serotonin-mediated increased responsiveness of phrenic motoneurons after CDR, TDR, and spinal cord injury. Accordingly, numerous components of the ventilatory control system exhibit plasticity after denervation or lesion-induced changes in breathing; this plasticity is uniform neither in magnitude nor in underlying mechanisms. A major need in future research is to determine whether “reorganization” within the central nervous system contributes to plasticity following lesion-induced changes in breathing." @default.
- W2048449925 created "2016-06-24" @default.
- W2048449925 creator A5087066345 @default.
- W2048449925 date "2003-02-01" @default.
- W2048449925 modified "2023-10-10" @default.
- W2048449925 title "Invited Review: Plasticity in the control of breathing following sensory denervation" @default.
- W2048449925 cites W1626312819 @default.
- W2048449925 cites W1640593424 @default.
- W2048449925 cites W1750942102 @default.
- W2048449925 cites W1757500502 @default.
- W2048449925 cites W178225000 @default.
- W2048449925 cites W1905084905 @default.
- W2048449925 cites W1917694489 @default.
- W2048449925 cites W1965864775 @default.
- W2048449925 cites W1968051328 @default.
- W2048449925 cites W1976230683 @default.
- W2048449925 cites W1979004829 @default.
- W2048449925 cites W1983782150 @default.
- W2048449925 cites W1987029049 @default.
- W2048449925 cites W1988125538 @default.
- W2048449925 cites W1991842115 @default.
- W2048449925 cites W1991842307 @default.
- W2048449925 cites W1998541379 @default.
- W2048449925 cites W2000764295 @default.
- W2048449925 cites W2005767445 @default.
- W2048449925 cites W2007197689 @default.
- W2048449925 cites W2010296843 @default.
- W2048449925 cites W2014168779 @default.
- W2048449925 cites W2015351285 @default.
- W2048449925 cites W2032990059 @default.
- W2048449925 cites W2033249986 @default.
- W2048449925 cites W2037233574 @default.
- W2048449925 cites W2037688283 @default.
- W2048449925 cites W2045637659 @default.
- W2048449925 cites W2049475620 @default.
- W2048449925 cites W2063080364 @default.
- W2048449925 cites W2065340380 @default.
- W2048449925 cites W2066223046 @default.
- W2048449925 cites W2074895544 @default.
- W2048449925 cites W2088608664 @default.
- W2048449925 cites W2094784948 @default.
- W2048449925 cites W2096548963 @default.
- W2048449925 cites W2102632295 @default.
- W2048449925 cites W2112030353 @default.
- W2048449925 cites W2120276843 @default.
- W2048449925 cites W2124579676 @default.
- W2048449925 cites W2125239217 @default.
- W2048449925 cites W2128810611 @default.
- W2048449925 cites W2133236751 @default.
- W2048449925 cites W2135557712 @default.
- W2048449925 cites W2136426349 @default.
- W2048449925 cites W2173860091 @default.
- W2048449925 cites W2176901822 @default.
- W2048449925 cites W2178876270 @default.
- W2048449925 cites W2180610019 @default.
- W2048449925 cites W2187212782 @default.
- W2048449925 cites W2189615524 @default.
- W2048449925 cites W2202600514 @default.
- W2048449925 cites W2206245038 @default.
- W2048449925 cites W2207525165 @default.
- W2048449925 cites W2222394236 @default.
- W2048449925 cites W2224528693 @default.
- W2048449925 cites W2226848466 @default.
- W2048449925 cites W2230496817 @default.
- W2048449925 cites W2233793390 @default.
- W2048449925 cites W2238846465 @default.
- W2048449925 cites W2246706037 @default.
- W2048449925 cites W2262756030 @default.
- W2048449925 cites W2267254823 @default.
- W2048449925 cites W2272744191 @default.
- W2048449925 cites W2278292778 @default.
- W2048449925 cites W2281783619 @default.
- W2048449925 cites W2287023282 @default.
- W2048449925 cites W2310658711 @default.
- W2048449925 cites W2322271915 @default.
- W2048449925 cites W2335217079 @default.
- W2048449925 cites W2341249703 @default.
- W2048449925 cites W2395204133 @default.
- W2048449925 cites W2399101367 @default.
- W2048449925 cites W2402043349 @default.
- W2048449925 cites W2412844795 @default.
- W2048449925 cites W2414883939 @default.
- W2048449925 cites W2417668954 @default.
- W2048449925 cites W2417886421 @default.
- W2048449925 cites W2426633269 @default.
- W2048449925 cites W2462934141 @default.
- W2048449925 cites W2466813848 @default.
- W2048449925 cites W2468072280 @default.
- W2048449925 cites W2475360648 @default.
- W2048449925 cites W2604970264 @default.
- W2048449925 cites W306067891 @default.
- W2048449925 cites W3142799038 @default.
- W2048449925 doi "https://doi.org/10.1152/japplphysiol.00602.2002" @default.
- W2048449925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12531915" @default.
- W2048449925 hasPublicationYear "2003" @default.
- W2048449925 type Work @default.
- W2048449925 sameAs 2048449925 @default.
- W2048449925 citedByCount "59" @default.