FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048452989> ?p ?o ?g. }

• W2048452989 endingPage "178" @default.
• W2048452989 startingPage "170" @default.
• W2048452989 abstract "Deletion of 11q23 is a common genetic aberration in nasopharyngeal carcinoma (NPC). Multiple candidate tumor suppressor genes (TSG) were mapped to this region but few of them were investigated in NPC. TSLC1 (tumor suppressor in lung cancer) is recently reported to be a putative TSG on 11q23. This gene was found to be inactivated by promoter hypermethylation in non-small cell lung carcinoma (NSCLC), liver cancer, and breast cancer. To study the role of TSLC1 gene in NPC tumorigenesis, we screened for mutations and aberrant methylation of TSLC1 gene in 5 NPC cell lines, 3 NPC xenografts, and 38 primary NPC cases. No somatic mutations of TSLC1 were detected in the NPC samples, but a 9-bp (CCACCACCA) deletion in exon 8 was found in a primary NPC and its corresponding blood sample. Bisulfite sequencing revealed aberrant methylation of TSLC1 promoter in four NPC cell lines. Loss of TSLC1 gene expression was found in two cell lines (HK-1 and CNE-2) with dense methylation. Expression of this gene was restored in these cell lines after treatment with demethylating agent 5-aza-2'-deoxycytidine. Our results showed that silencing of TSLC1 gene expression in NPC was associated with promoter hypermethylation. Promoter hypermethylation of TSLC1 gene was further illustrated in 34.2% (13/38) of primary NPCs. No aberrant promoter methylation was found in any of the four investigated normal nasopharyngeal epithelia. Frequent epigenetic inactivation of TSLC1 gene in NPC suggested that this gene is one of the target tumor suppressor genes of this endemic cancer." @default.
• W2048452989 created "2016-06-24" @default.
• W2048452989 creator A5009653804 @default.
• W2048452989 creator A5031515836 @default.
• W2048452989 creator A5041452564 @default.
• W2048452989 creator A5056618351 @default.
• W2048452989 creator A5062755889 @default.
• W2048452989 creator A5064464273 @default.
• W2048452989 creator A5065187079 @default.
• W2048452989 creator A5070461179 @default.
• W2048452989 creator A5087843177 @default.
• W2048452989 date "2003-11-19" @default.
• W2048452989 modified "2023-10-15" @default.
• W2048452989 title "Epigenetic inactivation ofTSLC1 gene in nasopharyngeal carcinoma" @default.
• W2048452989 cites W1533251376 @default.
• W2048452989 cites W1969649143 @default.
• W2048452989 cites W1972179955 @default.
• W2048452989 cites W1983036385 @default.
• W2048452989 cites W1988528619 @default.
• W2048452989 cites W2000098053 @default.
• W2048452989 cites W2008761361 @default.
• W2048452989 cites W2035480447 @default.
• W2048452989 cites W2037179040 @default.
• W2048452989 cites W2040578633 @default.
• W2048452989 cites W2044224794 @default.
• W2048452989 cites W2051427868 @default.
• W2048452989 cites W2074271791 @default.
• W2048452989 cites W2086994203 @default.
• W2048452989 cites W2126173204 @default.
• W2048452989 cites W2140370390 @default.
• W2048452989 cites W2318385725 @default.
• W2048452989 doi "https://doi.org/10.1002/mc.10156" @default.
• W2048452989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14639656" @default.
• W2048452989 hasPublicationYear "2003" @default.
• W2048452989 type Work @default.
• W2048452989 sameAs 2048452989 @default.
• W2048452989 citedByCount "65" @default.
• W2048452989 countsByYear W20484529892012 @default.
• W2048452989 countsByYear W20484529892013 @default.
• W2048452989 countsByYear W20484529892014 @default.
• W2048452989 countsByYear W20484529892015 @default.
• W2048452989 countsByYear W20484529892016 @default.
• W2048452989 countsByYear W20484529892017 @default.
• W2048452989 countsByYear W20484529892018 @default.
• W2048452989 countsByYear W20484529892019 @default.
• W2048452989 countsByYear W20484529892021 @default.
• W2048452989 countsByYear W20484529892022 @default.
• W2048452989 countsByYear W20484529892023 @default.
• W2048452989 crossrefType "journal-article" @default.
• W2048452989 hasAuthorship W2048452989A5009653804 @default.
• W2048452989 hasAuthorship W2048452989A5031515836 @default.
• W2048452989 hasAuthorship W2048452989A5041452564 @default.
• W2048452989 hasAuthorship W2048452989A5056618351 @default.
• W2048452989 hasAuthorship W2048452989A5062755889 @default.
• W2048452989 hasAuthorship W2048452989A5064464273 @default.
• W2048452989 hasAuthorship W2048452989A5065187079 @default.
• W2048452989 hasAuthorship W2048452989A5070461179 @default.
• W2048452989 hasAuthorship W2048452989A5087843177 @default.
• W2048452989 hasConcept C104317684 @default.
• W2048452989 hasConcept C121608353 @default.
• W2048452989 hasConcept C126322002 @default.
• W2048452989 hasConcept C150194340 @default.
• W2048452989 hasConcept C153911025 @default.
• W2048452989 hasConcept C189235521 @default.
• W2048452989 hasConcept C190727270 @default.
• W2048452989 hasConcept C2778264664 @default.
• W2048452989 hasConcept C2778997737 @default.
• W2048452989 hasConcept C2779277951 @default.
• W2048452989 hasConcept C33288867 @default.
• W2048452989 hasConcept C36823959 @default.
• W2048452989 hasConcept C41091548 @default.
• W2048452989 hasConcept C502942594 @default.
• W2048452989 hasConcept C509974204 @default.
• W2048452989 hasConcept C54355233 @default.
• W2048452989 hasConcept C555283112 @default.
• W2048452989 hasConcept C71924100 @default.
• W2048452989 hasConcept C86803240 @default.
• W2048452989 hasConceptScore W2048452989C104317684 @default.
• W2048452989 hasConceptScore W2048452989C121608353 @default.
• W2048452989 hasConceptScore W2048452989C126322002 @default.
• W2048452989 hasConceptScore W2048452989C150194340 @default.
• W2048452989 hasConceptScore W2048452989C153911025 @default.
• W2048452989 hasConceptScore W2048452989C189235521 @default.
• W2048452989 hasConceptScore W2048452989C190727270 @default.
• W2048452989 hasConceptScore W2048452989C2778264664 @default.
• W2048452989 hasConceptScore W2048452989C2778997737 @default.
• W2048452989 hasConceptScore W2048452989C2779277951 @default.
• W2048452989 hasConceptScore W2048452989C33288867 @default.
• W2048452989 hasConceptScore W2048452989C36823959 @default.
• W2048452989 hasConceptScore W2048452989C41091548 @default.
• W2048452989 hasConceptScore W2048452989C502942594 @default.
• W2048452989 hasConceptScore W2048452989C509974204 @default.
• W2048452989 hasConceptScore W2048452989C54355233 @default.
• W2048452989 hasConceptScore W2048452989C555283112 @default.
• W2048452989 hasConceptScore W2048452989C71924100 @default.
• W2048452989 hasConceptScore W2048452989C86803240 @default.
• W2048452989 hasIssue "4" @default.
• W2048452989 hasLocation W20484529891 @default.

• next