FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048453999> ?p ?o ?g. }

• W2048453999 endingPage "77" @default.
• W2048453999 startingPage "68" @default.
• W2048453999 abstract "Calcium currents through voltage-dependent Ca2+channels (VDCCs) in mammalian outer hair cells (OHCs) are generally considered to possess the pharmacological properties of L-type (dihydropyridine-sensitive) currents. However, the OHCs' low resting potentials and their slight depolarization upon sound stimuli suggest that the low voltage-activated channels may contribute to Ca2+regulation. We present morphological and electrophysiological evidence for the presence of the CaV3.1 T-type Ca2+channels, one of the low voltage-activated Ca2+channels, in mature rat OHCs. PCR experiments revealed the expression of CaV3.1, but not CaV3.2 or CaV3.3, in the mature rat cochlea. In situ hybridization and immunohistochemistry revealed expression of CaV3.1 in both inner and outer hair cells at the mRNA level, but only in the OHCs at the protein level. Western blot analysis of anti-CaV3.1 antibody showed a 242 kDa band in mature rat cochlear lysates. Patch-clamp recordings of OHCs isolated from rat cochleae after the onset of hearing revealed that whole-cell voltage-dependent Ca2+ currents were significantly increased in depolarizing steps from a holding potential of − 100 mV when compared with those from − 70 mV. Only the currents from − 100 mV manifested a distinct transient inward Ca2+ current, and this transient component was effectively blocked by 1 μM of the T-type-specific antagonist, mibefradil. Our data suggest an involvement of CaV3.1 in intracellular Ca2+regulation in mature OHCs." @default.
• W2048453999 created "2016-06-24" @default.
• W2048453999 creator A5008005637 @default.
• W2048453999 creator A5032978645 @default.
• W2048453999 creator A5034758525 @default.
• W2048453999 creator A5042583601 @default.
• W2048453999 creator A5046074596 @default.
• W2048453999 date "2008-03-01" @default.
• W2048453999 modified "2023-09-26" @default.
• W2048453999 title "The CaV3.1 T-type Ca2+channel contributes to voltage-dependent calcium currents in rat outer hair cells" @default.
• W2048453999 cites W1481839654 @default.
• W2048453999 cites W1506027146 @default.
• W2048453999 cites W1535462101 @default.
• W2048453999 cites W1597540845 @default.
• W2048453999 cites W1616459298 @default.
• W2048453999 cites W1623375774 @default.
• W2048453999 cites W1966182601 @default.
• W2048453999 cites W1968669554 @default.
• W2048453999 cites W1974015977 @default.
• W2048453999 cites W1981360660 @default.
• W2048453999 cites W1981526543 @default.
• W2048453999 cites W1981683941 @default.
• W2048453999 cites W1982939305 @default.
• W2048453999 cites W1986329747 @default.
• W2048453999 cites W1993010130 @default.
• W2048453999 cites W2002444757 @default.
• W2048453999 cites W2004193000 @default.
• W2048453999 cites W2005306177 @default.
• W2048453999 cites W2006623752 @default.
• W2048453999 cites W2008969728 @default.
• W2048453999 cites W2010651242 @default.
• W2048453999 cites W2011297027 @default.
• W2048453999 cites W2012699482 @default.
• W2048453999 cites W2020885203 @default.
• W2048453999 cites W2025354712 @default.
• W2048453999 cites W2037741778 @default.
• W2048453999 cites W2038283307 @default.
• W2048453999 cites W2056307676 @default.
• W2048453999 cites W2060155090 @default.
• W2048453999 cites W2065652959 @default.
• W2048453999 cites W2098924164 @default.
• W2048453999 cites W2117496744 @default.
• W2048453999 cites W2120778711 @default.
• W2048453999 cites W2151914411 @default.
• W2048453999 cites W2153224159 @default.
• W2048453999 cites W2155756146 @default.
• W2048453999 cites W2165490569 @default.
• W2048453999 cites W2171830917 @default.
• W2048453999 cites W2219416963 @default.
• W2048453999 cites W2329825317 @default.
• W2048453999 doi "https://doi.org/10.1016/j.brainres.2008.01.058" @default.
• W2048453999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18294617" @default.
• W2048453999 hasPublicationYear "2008" @default.
• W2048453999 type Work @default.
• W2048453999 sameAs 2048453999 @default.
• W2048453999 citedByCount "13" @default.
• W2048453999 countsByYear W20484539992016 @default.
• W2048453999 countsByYear W20484539992019 @default.
• W2048453999 countsByYear W20484539992020 @default.
• W2048453999 countsByYear W20484539992021 @default.
• W2048453999 countsByYear W20484539992022 @default.
• W2048453999 crossrefType "journal-article" @default.
• W2048453999 hasAuthorship W2048453999A5008005637 @default.
• W2048453999 hasAuthorship W2048453999A5032978645 @default.
• W2048453999 hasAuthorship W2048453999A5034758525 @default.
• W2048453999 hasAuthorship W2048453999A5042583601 @default.
• W2048453999 hasAuthorship W2048453999A5046074596 @default.
• W2048453999 hasConcept C12554922 @default.
• W2048453999 hasConcept C147944092 @default.
• W2048453999 hasConcept C169760540 @default.
• W2048453999 hasConcept C178790620 @default.
• W2048453999 hasConcept C185263204 @default.
• W2048453999 hasConcept C185592680 @default.
• W2048453999 hasConcept C18699975 @default.
• W2048453999 hasConcept C2778585322 @default.
• W2048453999 hasConcept C2778673320 @default.
• W2048453999 hasConcept C2780130748 @default.
• W2048453999 hasConcept C30979828 @default.
• W2048453999 hasConcept C4141045 @default.
• W2048453999 hasConcept C519063684 @default.
• W2048453999 hasConcept C79879829 @default.
• W2048453999 hasConcept C86803240 @default.
• W2048453999 hasConcept C95444343 @default.
• W2048453999 hasConceptScore W2048453999C12554922 @default.
• W2048453999 hasConceptScore W2048453999C147944092 @default.
• W2048453999 hasConceptScore W2048453999C169760540 @default.
• W2048453999 hasConceptScore W2048453999C178790620 @default.
• W2048453999 hasConceptScore W2048453999C185263204 @default.
• W2048453999 hasConceptScore W2048453999C185592680 @default.
• W2048453999 hasConceptScore W2048453999C18699975 @default.
• W2048453999 hasConceptScore W2048453999C2778585322 @default.
• W2048453999 hasConceptScore W2048453999C2778673320 @default.
• W2048453999 hasConceptScore W2048453999C2780130748 @default.
• W2048453999 hasConceptScore W2048453999C30979828 @default.
• W2048453999 hasConceptScore W2048453999C4141045 @default.
• W2048453999 hasConceptScore W2048453999C519063684 @default.
• W2048453999 hasConceptScore W2048453999C79879829 @default.
• W2048453999 hasConceptScore W2048453999C86803240 @default.

• next