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- W2048456245 endingPage "96" @default.
- W2048456245 startingPage "88" @default.
- W2048456245 abstract "Mitochondria are sensitive and efficient organelles that regulate essential biological processes including: energy metabolism, decoding and transduction of intracellular signals, and balance between cell death and survival. Of note, dysfunctions in mitochondrial physiology are a general hallmark of cancer cells, leading to transformation-related features such as altered cellular metabolism, survival under stress conditions and reduced apoptotic response to chemotherapy. Mitochondrial apoptosis is a finely regulated process that derives from activation of multiple signaling networks. A crucial biochemical requirement for transducing pro-apoptotic stimuli is represented by kinase-dependent phosphorylation cascades. In this context a pivotal role is played by the prolyl-isomerase Pin1, which translates Ser/Thr-Pro phosphorylation into conformational changes able to modify the activities of its substrates. In this review we will discuss the impact of Pin1 in regulating various aspects of apoptosis in different biological contexts with particular emphasis on cancer and neurodegenerative diseases." @default.
- W2048456245 created "2016-06-24" @default.
- W2048456245 creator A5001884411 @default.
- W2048456245 creator A5019299493 @default.
- W2048456245 creator A5058620782 @default.
- W2048456245 creator A5069062060 @default.
- W2048456245 date "2014-11-01" @default.
- W2048456245 modified "2023-10-14" @default.
- W2048456245 title "Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration" @default.
- W2048456245 cites W1489408430 @default.
- W2048456245 cites W1520563041 @default.
- W2048456245 cites W1541944730 @default.
- W2048456245 cites W1592377138 @default.
- W2048456245 cites W1662899239 @default.
- W2048456245 cites W1709865743 @default.
- W2048456245 cites W1963757800 @default.
- W2048456245 cites W1964483580 @default.
- W2048456245 cites W1964898641 @default.
- W2048456245 cites W1965029154 @default.
- W2048456245 cites W1965955990 @default.
- W2048456245 cites W1965991145 @default.
- W2048456245 cites W1966007015 @default.
- W2048456245 cites W1966165558 @default.
- W2048456245 cites W1968644287 @default.
- W2048456245 cites W1970924670 @default.
- W2048456245 cites W1971274526 @default.
- W2048456245 cites W1971696898 @default.
- W2048456245 cites W1974036368 @default.
- W2048456245 cites W1977258127 @default.
- W2048456245 cites W1978063913 @default.
- W2048456245 cites W1979618048 @default.
- W2048456245 cites W1979909921 @default.
- W2048456245 cites W1981006523 @default.
- W2048456245 cites W1982668924 @default.
- W2048456245 cites W1986535773 @default.
- W2048456245 cites W1989223012 @default.
- W2048456245 cites W1991343654 @default.
- W2048456245 cites W1992372128 @default.
- W2048456245 cites W1994017228 @default.
- W2048456245 cites W1994084445 @default.
- W2048456245 cites W1997533858 @default.
- W2048456245 cites W1999054269 @default.
- W2048456245 cites W2000511416 @default.
- W2048456245 cites W2001871510 @default.
- W2048456245 cites W2002285022 @default.
- W2048456245 cites W2002936090 @default.
- W2048456245 cites W2004415979 @default.
- W2048456245 cites W2006099686 @default.
- W2048456245 cites W2006382458 @default.
- W2048456245 cites W2006413040 @default.
- W2048456245 cites W2008898220 @default.
- W2048456245 cites W2009183764 @default.
- W2048456245 cites W2009187135 @default.
- W2048456245 cites W2009661890 @default.
- W2048456245 cites W2011383001 @default.
- W2048456245 cites W2012745341 @default.
- W2048456245 cites W2015859477 @default.
- W2048456245 cites W2017626786 @default.
- W2048456245 cites W2020230403 @default.
- W2048456245 cites W2020527014 @default.
- W2048456245 cites W2022899908 @default.
- W2048456245 cites W2026042310 @default.
- W2048456245 cites W2029884468 @default.
- W2048456245 cites W2030891330 @default.
- W2048456245 cites W2031588422 @default.
- W2048456245 cites W2034773856 @default.
- W2048456245 cites W2041268976 @default.
- W2048456245 cites W2044098205 @default.
- W2048456245 cites W2048470036 @default.
- W2048456245 cites W2050000741 @default.
- W2048456245 cites W2050621375 @default.
- W2048456245 cites W2050745715 @default.
- W2048456245 cites W2052049672 @default.
- W2048456245 cites W2054311839 @default.
- W2048456245 cites W2057628925 @default.
- W2048456245 cites W2057839285 @default.
- W2048456245 cites W2059007379 @default.
- W2048456245 cites W2059977521 @default.
- W2048456245 cites W2059999514 @default.
- W2048456245 cites W2062555640 @default.
- W2048456245 cites W2063822655 @default.
- W2048456245 cites W2071760372 @default.
- W2048456245 cites W2076020247 @default.
- W2048456245 cites W2078047263 @default.
- W2048456245 cites W2078189636 @default.
- W2048456245 cites W2080458504 @default.
- W2048456245 cites W2082035472 @default.
- W2048456245 cites W2087908615 @default.
- W2048456245 cites W2089334896 @default.
- W2048456245 cites W2090248730 @default.
- W2048456245 cites W2090854321 @default.
- W2048456245 cites W2092108176 @default.
- W2048456245 cites W2092678097 @default.
- W2048456245 cites W2092950531 @default.
- W2048456245 cites W2097259163 @default.
- W2048456245 cites W2098647609 @default.
- W2048456245 cites W2109903379 @default.
- W2048456245 cites W2110942624 @default.