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• W2048461494 endingPage "1740" @default.
• W2048461494 startingPage "1731" @default.
• W2048461494 abstract "Abstract The quinolones are an important group of synthetic antimicrobial drugs used for treating bacterial diseases of humans and animals. Microorganisms transform antimicrobial quinolones (including fluoroquinolones) and the pharmacologically related naphthyridones, pyranoacridones, and cinnolones to a variety of metabolites. The biotransformation processes involve hydroxylation of methyl groups; hydroxylation of aliphatic and aromatic rings; oxidation of alcohols and amines; reduction of carboxyl groups; removal of methyl, carboxyl, fluoro, and cyano groups; addition of formyl, acetyl, nitrosyl, and cyclopentenone groups; and cleavage of aliphatic and aromatic rings. Most of these reactions greatly reduce or eliminate the antimicrobial activity of the quinolones." @default.
• W2048461494 created "2016-06-24" @default.
• W2048461494 creator A5032064075 @default.
• W2048461494 creator A5054428234 @default.
• W2048461494 date "2012-12-01" @default.
• W2048461494 modified "2023-09-26" @default.
• W2048461494 title "Microbial transformations of antimicrobial quinolones and related drugs" @default.
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• W2048461494 doi "https://doi.org/10.1007/s10295-012-1194-x" @default.
• W2048461494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23007957" @default.
• W2048461494 hasPublicationYear "2012" @default.
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