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• W2048462055 abstract "To quantify tumor motion and assess the impact of abdominal compression in patients with medically inoperable Stage I Non–Small Cell Lung Cancer treated with SBRT or 3D-CRT. Retrospective review of clinical Stage I NSCLC of the left lung treated with definitive SBRT (40 Gy to 60 Gy in 3–5 Fractions) or accelerated 3D-CRT (70 Gy in 20–28 Fractions). 4D-CT simulation using the Real-time Position Management® (RPM) system (Varian Medical Systems, Palo Alto, CA) was performed for treatment planning in all patients, while abdominal compression with the BodyFIX system (Medical Intelligence, Schwabmünchen, Germany) was employed only in patients treated with SBRT. For this review the analysis was limited to left sided tumors in patients without a previous history of thoracic surgery or radiation therapy. Tumor motion was defined as the difference in tumor position at the peak inspiratory and expiratory breathing phases. 27 patients with left sided tumors (upper lobe = 12, lower lobe = 15) underwent SBRT (n=13) or 3D-CRT (n=14). The overall mean tumor motion was 9.4 mm (range, 3.6–15 mm), 2.1 mm (range, 0–9), and 0.6 mm (range, 0–2) for superior-inferior (SI), anterior-posterior (AP), and lateral directions for LLL tumors. Mean tumor motion was 3.7 mm (range, 0–9 mm), 2.9 mm (range, 0–4.8 mm), and 0.5 mm (range, 0–2 mm), respectively, in the SI, AP, and lateral directions for LUL tumors. LLL location was associated with significantly more tumor motion in the SI (p=0.0006) direction, but not in the AP (p=0.23), or lateral (p=0.1) directions, compared to LUL tumors. The use of abdominal compression did not significantly impact tumor motion in the SI direction in either LLL (p=0.6) or LUL tumors (p = 0.3). Abdominal plate screw position correlated with SI motion in patients undergoing SBRT for LLL tumors (p = 0.01), but not in patients undergoing SBRT for LUL tumors (p=0.07). LUL tumors had minimal SI motion with (mean 3.1 mm) or without (mean 4.1 mm) abdominal compression. Our experience with 4D-CT confirms increased SI tumor motion in patients with Stage I lower lobe tumors. Patients with upper lobe tumors had minimal motion (< 1 cm) and may not require routine abdominal compression. In this study, rigid fixation with abdominal compression did not appear to decrease SI motion in lower lobe tumors. Further studies should focus on abdominal plate position and compression force to provide consistency in restricting tumor motion." @default.
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• W2048462055 date "2009-11-01" @default.
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• W2048462055 title "Analysis of Tumor Motion using Four-dimensional (4D) CT in Patients undergoing Stereotactic Body Radiation Therapy (SBRT) or Hypofractionated 3D Conformal Radiation Therapy (3D-CRT) for Stage I Non–small Cell Lung Cancer" @default.
• W2048462055 doi "https://doi.org/10.1016/j.ijrobp.2009.07.1071" @default.
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