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- W2048464694 abstract "A new synthesis of a tritiated photosensitive nicotinic agonist ([3H]–AC5), which uses [3H2] as the source of radioactivity, is described. Several improvements have been introduced to establish a reliable five-step synthesis displaying satisfactory overall yields (45%) and requiring a single purification (HPLC) in the final step. This photosensitive radiolabelled probe will enable us to undertake a time-resolved photolabelling study on the nicotinic acetylcholine receptor in order to analyze at the molecular level the allosteric transitions occurring after agonist stimulation. Copyright © 2002 John Wiley & Sons, Ltd." @default.
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- W2048464694 date "2002-01-01" @default.
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- W2048464694 title "New and convenient synthesis of a tritiated photoactivatable nicotinic agonist: [3H]-AC5" @default.
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- W2048464694 doi "https://doi.org/10.1002/jlcr.614" @default.
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