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- W2048466476 endingPage "179" @default.
- W2048466476 startingPage "168" @default.
- W2048466476 abstract "Traumatic injury to the mammalian spinal cord is a highly dynamic process characterized by a complex pattern of pervasive and destructive biochemical and pathophysiological events that limit the potential for functional recovery. Currently, there are no effective therapies for the treatment of spinal cord injury (SCI) and this is due, in part, to the widespread impact of the secondary injury cascades, including edema, ischemia, excitotoxicity, inflammation, oxidative damage, and activation of necrotic and apoptotic cell death signaling events. In addition, many of the signaling pathways associated with these cascades intersect and initiate other secondary injury events. Therefore, it can be argued that therapeutic strategies targeting a specific biochemical cascade may not provide the best approach for promoting functional recovery. A systems approach at the subcellular level may provide a better strategy for promoting cell survival and function and, as a consequence, improve functional outcomes following SCI. One such approach is to study the impact of SCI on the biology and function of mitochondria, which serve a major role in cellular bioenergetics, function, and survival. In this review, we will briefly describe the importance and unique properties of mitochondria in the spinal cord, and what is known about the response of mitochondria to SCI. We will also discuss a number of strategies with the potential to promote mitochondrial function following SCI." @default.
- W2048466476 created "2016-06-24" @default.
- W2048466476 creator A5014595690 @default.
- W2048466476 creator A5021527876 @default.
- W2048466476 creator A5054196760 @default.
- W2048466476 creator A5082666900 @default.
- W2048466476 date "2011-03-01" @default.
- W2048466476 modified "2023-10-13" @default.
- W2048466476 title "Targeting Mitochondrial Function for the Treatment of Acute Spinal Cord Injury" @default.
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