FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048466881> ?p ?o ?g. }

• W2048466881 endingPage "3207" @default.
• W2048466881 startingPage "3200" @default.
• W2048466881 abstract "The action of LH is mediated through specific plasma membrane receptors that are both up- and down-regulated in the ovary during the reproductive cycle. Using immature rats treated with PMSG and hCG as a model system, we have studied the regulation and distribution of LH receptor mRNA in different cell types during follicle development, ovulation, and luteinization by Northern blot and in situ hybridization. In untreated rats, LH receptor mRNA was below the detection level in granulosa cells, cumulus cells, and oocytes, while low levels of LH receptor mRNA were found in the thecal cells. After stimulation with PMSG, expression of LH receptor mRNA was enhanced in the thecal-interstitial cells, while a more dramatic increase in receptor mRNA abundance took place in granulosa cells of large tertiary follicles. In these follicles, the abundance of LH receptor mRNA varied among different subpopulations of granulosa cells, with mural granulosa cells close to the basement membrane exhibiting higher levels than granulosa cells located closer to the antrum, and cumulus cells and the oocyte lacking detectable hybridization signal. The uneven expression of LH receptor mRNA endows different ovarian cells with varying hormonal responsiveness. After an ovulatory dose of hCG, LH receptor mRNA levels were dramatically decreased, particularly in the granulosa cells of preovulatory follicles, to reach the lowest levels just before ovulation. During the transformation of ovulated follicles into corpora lutea, the expression of LH receptor message was again increased. Our results reveal that the previously documented regulation of the LH receptorbinding activity during ovarian development correlates with expression of the LH receptor transcripts, suggesting that the LH receptor gene is regulated in a complex manner during the periovulatory period to achieve cell-specific expression together with gonadotropin induction and suppression of receptor gene activity. (Endocrinology129: 3200–3207, 1991)" @default.
• W2048466881 created "2016-06-24" @default.
• W2048466881 creator A5006681163 @default.
• W2048466881 creator A5007417059 @default.
• W2048466881 creator A5011756139 @default.
• W2048466881 creator A5051668998 @default.
• W2048466881 creator A5061996911 @default.
• W2048466881 date "1991-12-01" @default.
• W2048466881 modified "2023-10-18" @default.
• W2048466881 title "Localization of Luteinizing Hormone Receptor Messenger Ribonucleic Acid Expression in Ovarian Cell Types during Follicle Development and Ovulation*" @default.
• W2048466881 cites W14081025 @default.
• W2048466881 cites W1589012184 @default.
• W2048466881 cites W1964769283 @default.
• W2048466881 cites W1988501054 @default.
• W2048466881 cites W1992032810 @default.
• W2048466881 cites W1996339709 @default.
• W2048466881 cites W2006418970 @default.
• W2048466881 cites W2008535216 @default.
• W2048466881 cites W2014744889 @default.
• W2048466881 cites W2016219359 @default.
• W2048466881 cites W2021191487 @default.
• W2048466881 cites W2021445249 @default.
• W2048466881 cites W2029858462 @default.
• W2048466881 cites W2032219172 @default.
• W2048466881 cites W2047416689 @default.
• W2048466881 cites W2052636645 @default.
• W2048466881 cites W2055011117 @default.
• W2048466881 cites W2056196724 @default.
• W2048466881 cites W2058061901 @default.
• W2048466881 cites W2063024725 @default.
• W2048466881 cites W2064982147 @default.
• W2048466881 cites W2073261011 @default.
• W2048466881 cites W2076710220 @default.
• W2048466881 cites W2077077811 @default.
• W2048466881 cites W2081104479 @default.
• W2048466881 cites W2086650080 @default.
• W2048466881 cites W2089557734 @default.
• W2048466881 cites W2093909923 @default.
• W2048466881 cites W2106306838 @default.
• W2048466881 cites W2110978920 @default.
• W2048466881 cites W2126757571 @default.
• W2048466881 cites W2131391777 @default.
• W2048466881 cites W2139448460 @default.
• W2048466881 cites W2144634347 @default.
• W2048466881 cites W2146903486 @default.
• W2048466881 cites W40754507 @default.
• W2048466881 cites W601452628 @default.
• W2048466881 doi "https://doi.org/10.1210/endo-129-6-3200" @default.
• W2048466881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1954899" @default.
• W2048466881 hasPublicationYear "1991" @default.
• W2048466881 type Work @default.
• W2048466881 sameAs 2048466881 @default.
• W2048466881 citedByCount "274" @default.
• W2048466881 countsByYear W20484668812012 @default.
• W2048466881 countsByYear W20484668812013 @default.
• W2048466881 countsByYear W20484668812014 @default.
• W2048466881 countsByYear W20484668812015 @default.
• W2048466881 countsByYear W20484668812016 @default.
• W2048466881 countsByYear W20484668812017 @default.
• W2048466881 countsByYear W20484668812018 @default.
• W2048466881 countsByYear W20484668812019 @default.
• W2048466881 countsByYear W20484668812020 @default.
• W2048466881 countsByYear W20484668812021 @default.
• W2048466881 countsByYear W20484668812022 @default.
• W2048466881 countsByYear W20484668812023 @default.
• W2048466881 crossrefType "journal-article" @default.
• W2048466881 hasAuthorship W2048466881A5006681163 @default.
• W2048466881 hasAuthorship W2048466881A5007417059 @default.
• W2048466881 hasAuthorship W2048466881A5011756139 @default.
• W2048466881 hasAuthorship W2048466881A5051668998 @default.
• W2048466881 hasAuthorship W2048466881A5061996911 @default.
• W2048466881 hasConcept C102570824 @default.
• W2048466881 hasConcept C104317684 @default.
• W2048466881 hasConcept C105580179 @default.
• W2048466881 hasConcept C126322002 @default.
• W2048466881 hasConcept C134018914 @default.
• W2048466881 hasConcept C170493617 @default.
• W2048466881 hasConcept C175805485 @default.
• W2048466881 hasConcept C196843134 @default.
• W2048466881 hasConcept C2777203538 @default.
• W2048466881 hasConcept C2777702977 @default.
• W2048466881 hasConcept C2778324911 @default.
• W2048466881 hasConcept C2778575703 @default.
• W2048466881 hasConcept C2778782382 @default.
• W2048466881 hasConcept C2779279165 @default.
• W2048466881 hasConcept C2780536345 @default.
• W2048466881 hasConcept C29390026 @default.
• W2048466881 hasConcept C5512455 @default.
• W2048466881 hasConcept C55493867 @default.
• W2048466881 hasConcept C71315377 @default.
• W2048466881 hasConcept C71924100 @default.
• W2048466881 hasConcept C81439078 @default.
• W2048466881 hasConcept C86803240 @default.
• W2048466881 hasConcept C87073359 @default.
• W2048466881 hasConcept C95444343 @default.
• W2048466881 hasConceptScore W2048466881C102570824 @default.
• W2048466881 hasConceptScore W2048466881C104317684 @default.
• W2048466881 hasConceptScore W2048466881C105580179 @default.

• next