FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048473457> ?p ?o ?g. }

• W2048473457 endingPage "105" @default.
• W2048473457 startingPage "90" @default.
• W2048473457 abstract "Alzheimer disease is characterized by accumulation of β-amyloid (Aβ) and cognitive dysfunctions linked to early loss of cholinergic neurons. As estrogen-based hormone replacement therapy has beneficial effects on cognition of demented patients, and it may prevent memory impairments, we investigated the effect of estrogen-pretreatment on Aβ-induced cholinergic neurodegeneration in the nucleus basalis magnocellularis (NBM). We tested which Aβ species induces the more pronounced cholinotoxic effect in vivo. We injected different Aβ assemblies in the NBM of mice, and measured cholinergic cell and cortical fiber loss. Spherical Aβ oligomers had the most toxic effect. Pretreatment of ovariectomized mice with estrogen before Aβ injection decreased cholinergic neuron loss and partly prevented fiber degeneration. By using proteomics, we searched for proteins involved in estrogen-mediated protection and in Aβ toxicity 24 h following injection. The change in expression of, e.g., DJ-1, NADH ubiquinone oxidoreductase, ATP synthase, phosphatidylethanolamine-binding protein 1, protein phosphatase 2A and dimethylarginine dimethylaminohydrolase 1 support our hypothesis that Aβ induces mitochondrial dysfunction, decreases MAPK signaling, and increases NOS activation in NBM. On the other hand, altered expression of, e.g., MAP kinase kinase 1 and 2, protein phosphatase 1 and 2A by Aβ might increase MAPK suppression and NOS signaling in the cortical target area. Estrogen pretreatment reversed most of the changes in the proteome in both areas. Our experiments suggest that regulation of the MAPK pathway, mitochondrial pH and NO production may all contribute to Aβ toxicity, and their regulation can be prevented partly by estrogen pretreatment." @default.
• W2048473457 created "2016-06-24" @default.
• W2048473457 creator A5009369647 @default.
• W2048473457 creator A5035986686 @default.
• W2048473457 creator A5053300892 @default.
• W2048473457 creator A5055259526 @default.
• W2048473457 creator A5060217047 @default.
• W2048473457 creator A5069139292 @default.
• W2048473457 creator A5069728005 @default.
• W2048473457 creator A5077240772 @default.
• W2048473457 creator A5082940933 @default.
• W2048473457 creator A5084703314 @default.
• W2048473457 creator A5088175077 @default.
• W2048473457 creator A5091529899 @default.
• W2048473457 date "2010-10-08" @default.
• W2048473457 modified "2023-10-18" @default.
• W2048473457 title "Effects of Estrogen on Beta-Amyloid-Induced Cholinergic Cell Death in the Nucleus Basalis Magnocellularis" @default.
• W2048473457 cites W1582745215 @default.
• W2048473457 cites W1662308449 @default.
• W2048473457 cites W1946313188 @default.
• W2048473457 cites W1967438883 @default.
• W2048473457 cites W1969569756 @default.
• W2048473457 cites W1972188596 @default.
• W2048473457 cites W1975829688 @default.
• W2048473457 cites W1979336030 @default.
• W2048473457 cites W1980380817 @default.
• W2048473457 cites W1981072854 @default.
• W2048473457 cites W1982706802 @default.
• W2048473457 cites W1987280274 @default.
• W2048473457 cites W1987289944 @default.
• W2048473457 cites W1987624864 @default.
• W2048473457 cites W1990883896 @default.
• W2048473457 cites W1991988242 @default.
• W2048473457 cites W1992571809 @default.
• W2048473457 cites W1996731318 @default.
• W2048473457 cites W1996917933 @default.
• W2048473457 cites W1998136871 @default.
• W2048473457 cites W2000076912 @default.
• W2048473457 cites W2002819578 @default.
• W2048473457 cites W2003631852 @default.
• W2048473457 cites W2004584009 @default.
• W2048473457 cites W2012144638 @default.
• W2048473457 cites W2013755949 @default.
• W2048473457 cites W2020555937 @default.
• W2048473457 cites W2021784772 @default.
• W2048473457 cites W2021911635 @default.
• W2048473457 cites W2023187813 @default.
• W2048473457 cites W2023316858 @default.
• W2048473457 cites W2030001972 @default.
• W2048473457 cites W2031286114 @default.
• W2048473457 cites W2033847972 @default.
• W2048473457 cites W2035672697 @default.
• W2048473457 cites W2035740858 @default.
• W2048473457 cites W2045331361 @default.
• W2048473457 cites W2045525515 @default.
• W2048473457 cites W2047214544 @default.
• W2048473457 cites W2047693500 @default.
• W2048473457 cites W2051132333 @default.
• W2048473457 cites W2052722557 @default.
• W2048473457 cites W2054463640 @default.
• W2048473457 cites W2057176833 @default.
• W2048473457 cites W2059763143 @default.
• W2048473457 cites W2059940170 @default.
• W2048473457 cites W2064111465 @default.
• W2048473457 cites W2069705189 @default.
• W2048473457 cites W2072405601 @default.
• W2048473457 cites W2075481535 @default.
• W2048473457 cites W2080274663 @default.
• W2048473457 cites W2083293065 @default.
• W2048473457 cites W2083317764 @default.
• W2048473457 cites W2087139961 @default.
• W2048473457 cites W2090724400 @default.
• W2048473457 cites W2092402359 @default.
• W2048473457 cites W2096429475 @default.
• W2048473457 cites W2097391583 @default.
• W2048473457 cites W2099370040 @default.
• W2048473457 cites W2102545959 @default.
• W2048473457 cites W2109727228 @default.
• W2048473457 cites W2112468330 @default.
• W2048473457 cites W2115295553 @default.
• W2048473457 cites W2119504151 @default.
• W2048473457 cites W2120466655 @default.
• W2048473457 cites W2120701804 @default.
• W2048473457 cites W2128007559 @default.
• W2048473457 cites W2133631618 @default.
• W2048473457 cites W2142276934 @default.
• W2048473457 cites W2147210134 @default.
• W2048473457 cites W2150034989 @default.
• W2048473457 cites W2153125904 @default.
• W2048473457 cites W2164789180 @default.
• W2048473457 cites W257908771 @default.
• W2048473457 doi "https://doi.org/10.1159/000321119" @default.
• W2048473457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20938166" @default.
• W2048473457 hasPublicationYear "2010" @default.
• W2048473457 type Work @default.
• W2048473457 sameAs 2048473457 @default.
• W2048473457 citedByCount "18" @default.
• W2048473457 countsByYear W20484734572012 @default.

• next