Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048481176> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2048481176 endingPage "82" @default.
- W2048481176 startingPage "74" @default.
- W2048481176 abstract "Eotaxin-3/CCL26 is an agonist for chemokine receptor 3 (CCR3) and a natural antagonist for CCR1, CCR2 and CCR5. CCL26 expression by non-haematopoietic cells has been well documented; however, no studies to date have demonstrated CCL26 expression by leucocytes. In this study, we investigated the ability of human monocytic cells to produce CCL26 in response to cytokines. We found that interleukin-4 (IL-4) increased the expression of CCL26 messenger RNA (mRNA) and protein in U937 cells, in human monocytes and in human monocyte-derived macrophages. Tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) alone did not induce CCL26 expression, yet these pro-inflammatory cytokines synergized with IL-4 to increase CCL26 protein expression. Signal transducer and activator of transcription 6 (STAT6) was not affected by costimulation with TNF-alpha, suggesting that the synergy between IL-4 and TNF-alpha occurs at a step downstream of STAT6 activation. Co-incubation of interferon-gamma (IFN-gamma) with IL-4 had no effect on CCL26 protein release. By contrast, pretreatment with IFN-gamma decreased total STAT6 protein, blocked IL-4-mediated STAT6 phosphorylation and decreased IL-4-mediated CCL26 mRNA expression and protein release. These data show that IL-4 and pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IFN-gamma regulate CCL26 synthesis in human monocytic cells, which may be important in regulating monocyte inflammatory responses." @default.
- W2048481176 created "2016-06-24" @default.
- W2048481176 creator A5008452248 @default.
- W2048481176 creator A5033101588 @default.
- W2048481176 creator A5085017229 @default.
- W2048481176 date "2010-05-01" @default.
- W2048481176 modified "2023-10-01" @default.
- W2048481176 title "Regulation of eotaxin-3/CCL26 expression in human monocytic cells" @default.
- W2048481176 cites W1482383475 @default.
- W2048481176 cites W1532658876 @default.
- W2048481176 cites W1569649197 @default.
- W2048481176 cites W1595975240 @default.
- W2048481176 cites W1598071025 @default.
- W2048481176 cites W1844440003 @default.
- W2048481176 cites W1971747881 @default.
- W2048481176 cites W1973677690 @default.
- W2048481176 cites W1976959374 @default.
- W2048481176 cites W1987251700 @default.
- W2048481176 cites W1988876083 @default.
- W2048481176 cites W1988983742 @default.
- W2048481176 cites W1997069932 @default.
- W2048481176 cites W1997444277 @default.
- W2048481176 cites W1999692098 @default.
- W2048481176 cites W2015067428 @default.
- W2048481176 cites W2019608331 @default.
- W2048481176 cites W2023520187 @default.
- W2048481176 cites W2023745683 @default.
- W2048481176 cites W2029268155 @default.
- W2048481176 cites W2032928419 @default.
- W2048481176 cites W2044052957 @default.
- W2048481176 cites W2055482395 @default.
- W2048481176 cites W2056001110 @default.
- W2048481176 cites W2068559630 @default.
- W2048481176 cites W2085026240 @default.
- W2048481176 cites W2113151375 @default.
- W2048481176 cites W2122765278 @default.
- W2048481176 cites W2137664573 @default.
- W2048481176 cites W2144846148 @default.
- W2048481176 cites W2152241963 @default.
- W2048481176 cites W2171182079 @default.
- W2048481176 cites W2171524340 @default.
- W2048481176 cites W4313309880 @default.
- W2048481176 doi "https://doi.org/10.1111/j.1365-2567.2009.03214.x" @default.
- W2048481176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2855795" @default.
- W2048481176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20059579" @default.
- W2048481176 hasPublicationYear "2010" @default.
- W2048481176 type Work @default.
- W2048481176 sameAs 2048481176 @default.
- W2048481176 citedByCount "17" @default.
- W2048481176 countsByYear W20484811762012 @default.
- W2048481176 countsByYear W20484811762013 @default.
- W2048481176 countsByYear W20484811762015 @default.
- W2048481176 countsByYear W20484811762016 @default.
- W2048481176 countsByYear W20484811762017 @default.
- W2048481176 countsByYear W20484811762020 @default.
- W2048481176 countsByYear W20484811762021 @default.
- W2048481176 countsByYear W20484811762022 @default.
- W2048481176 countsByYear W20484811762023 @default.
- W2048481176 crossrefType "journal-article" @default.
- W2048481176 hasAuthorship W2048481176A5008452248 @default.
- W2048481176 hasAuthorship W2048481176A5033101588 @default.
- W2048481176 hasAuthorship W2048481176A5085017229 @default.
- W2048481176 hasBestOaLocation W20484811762 @default.
- W2048481176 hasConcept C185592680 @default.
- W2048481176 hasConcept C86803240 @default.
- W2048481176 hasConcept C95444343 @default.
- W2048481176 hasConceptScore W2048481176C185592680 @default.
- W2048481176 hasConceptScore W2048481176C86803240 @default.
- W2048481176 hasConceptScore W2048481176C95444343 @default.
- W2048481176 hasIssue "1" @default.
- W2048481176 hasLocation W20484811761 @default.
- W2048481176 hasLocation W20484811762 @default.
- W2048481176 hasLocation W20484811763 @default.
- W2048481176 hasOpenAccess W2048481176 @default.
- W2048481176 hasPrimaryLocation W20484811761 @default.
- W2048481176 hasRelatedWork W1531601525 @default.
- W2048481176 hasRelatedWork W2319480705 @default.
- W2048481176 hasRelatedWork W2384464875 @default.
- W2048481176 hasRelatedWork W2398689458 @default.
- W2048481176 hasRelatedWork W2606230654 @default.
- W2048481176 hasRelatedWork W2607424097 @default.
- W2048481176 hasRelatedWork W2748952813 @default.
- W2048481176 hasRelatedWork W2899084033 @default.
- W2048481176 hasRelatedWork W2948807893 @default.
- W2048481176 hasRelatedWork W2778153218 @default.
- W2048481176 hasVolume "130" @default.
- W2048481176 isParatext "false" @default.
- W2048481176 isRetracted "false" @default.
- W2048481176 magId "2048481176" @default.
- W2048481176 workType "article" @default.