Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048482227> ?p ?o ?g. }
- W2048482227 endingPage "1352" @default.
- W2048482227 startingPage "1341" @default.
- W2048482227 abstract "Populations in north central China are at high risk for oesophageal squamous cell carcinoma (ESCC) and gastric cancer (GC), and genetic variation in epigenetic machinery genes and pathways may contribute to this risk.We used the adaptive multilocus joint test to analyse 192 epigenetic genes involved in chromatin remodelling, DNA methylation and microRNA biosynthesis in 1942 ESCC and 1758 GC cases [1126 cardia (GCA) and 632 non-cardia adenocarcinoma (GNCA)] and 2111 controls with Chinese ancestry. We examined potential function of risk alleles using in silico and expression quantitative trait loci (eQTLs) analyses.Suggestive pathway-based associations were observed for the overall epigenetic (P-value(PATH) = 0.034) and chromatin remodelling (P-value(PATH) = 0.039) pathways with risk of GCA, but not GC, GNCA or ESCC. Overall, 37 different epigenetic machinery genes were associated with risk of one or more upper gastrointestinal (UGI) cancer sites (P-value(GENE )< 0.05), including 14 chromatin remodelling genes whose products are involved in the regulation of HOX genes. We identified a gastric eQTL (rs12724079; rho = 0.37; P = 0.0006) which regulates mRNA expression of ASH1L. Several suggestive eQTLs were also found in oesophageal (rs10898459 in EED), gastric cardia (rs7157322 in DICER1; rs8179271 in ASH1L), and gastric non-cardia (rs1790733 in PPP1CA) tissues.Results of our analyses provide limited but suggestive evidence for a role of epigenetic gene variation in the aetiology of UGI cancer." @default.
- W2048482227 created "2016-06-24" @default.
- W2048482227 creator A5000502483 @default.
- W2048482227 creator A5008522290 @default.
- W2048482227 creator A5011772607 @default.
- W2048482227 creator A5012823292 @default.
- W2048482227 creator A5014333073 @default.
- W2048482227 creator A5015169877 @default.
- W2048482227 creator A5023397446 @default.
- W2048482227 creator A5023533442 @default.
- W2048482227 creator A5026420258 @default.
- W2048482227 creator A5030086195 @default.
- W2048482227 creator A5037413259 @default.
- W2048482227 creator A5048427429 @default.
- W2048482227 creator A5054393035 @default.
- W2048482227 creator A5055646675 @default.
- W2048482227 creator A5060888364 @default.
- W2048482227 creator A5063007431 @default.
- W2048482227 creator A5072634086 @default.
- W2048482227 creator A5073008351 @default.
- W2048482227 creator A5077804071 @default.
- W2048482227 creator A5080559639 @default.
- W2048482227 creator A5081457672 @default.
- W2048482227 creator A5082191284 @default.
- W2048482227 creator A5085251424 @default.
- W2048482227 creator A5089976309 @default.
- W2048482227 creator A5091653870 @default.
- W2048482227 date "2015-04-27" @default.
- W2048482227 modified "2023-10-18" @default.
- W2048482227 title "Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers" @default.
- W2048482227 cites W1511799267 @default.
- W2048482227 cites W1934392702 @default.
- W2048482227 cites W1964963969 @default.
- W2048482227 cites W1967206377 @default.
- W2048482227 cites W1967518777 @default.
- W2048482227 cites W1971460830 @default.
- W2048482227 cites W1975600230 @default.
- W2048482227 cites W1980017443 @default.
- W2048482227 cites W1980937575 @default.
- W2048482227 cites W1981544129 @default.
- W2048482227 cites W1982606761 @default.
- W2048482227 cites W1985444222 @default.
- W2048482227 cites W1986779793 @default.
- W2048482227 cites W1988399301 @default.
- W2048482227 cites W1991153319 @default.
- W2048482227 cites W1991704009 @default.
- W2048482227 cites W1993363553 @default.
- W2048482227 cites W1994919923 @default.
- W2048482227 cites W2003751484 @default.
- W2048482227 cites W2007774666 @default.
- W2048482227 cites W2013195055 @default.
- W2048482227 cites W2013912721 @default.
- W2048482227 cites W2018243060 @default.
- W2048482227 cites W2022658622 @default.
- W2048482227 cites W2023097916 @default.
- W2048482227 cites W2031341812 @default.
- W2048482227 cites W2037589121 @default.
- W2048482227 cites W2038306548 @default.
- W2048482227 cites W2039665607 @default.
- W2048482227 cites W2055264087 @default.
- W2048482227 cites W2058008546 @default.
- W2048482227 cites W2063408296 @default.
- W2048482227 cites W2066088817 @default.
- W2048482227 cites W2067295843 @default.
- W2048482227 cites W2075853235 @default.
- W2048482227 cites W2075972745 @default.
- W2048482227 cites W2077284520 @default.
- W2048482227 cites W2078620068 @default.
- W2048482227 cites W2087467445 @default.
- W2048482227 cites W2088181514 @default.
- W2048482227 cites W2088335869 @default.
- W2048482227 cites W2091068881 @default.
- W2048482227 cites W2092145430 @default.
- W2048482227 cites W2097848080 @default.
- W2048482227 cites W2099818637 @default.
- W2048482227 cites W2100829650 @default.
- W2048482227 cites W2102141030 @default.
- W2048482227 cites W2107587308 @default.
- W2048482227 cites W2114989000 @default.
- W2048482227 cites W2116541444 @default.
- W2048482227 cites W2122341955 @default.
- W2048482227 cites W2124499207 @default.
- W2048482227 cites W2127236929 @default.
- W2048482227 cites W2130979840 @default.
- W2048482227 cites W2131847789 @default.
- W2048482227 cites W2136373438 @default.
- W2048482227 cites W2139362027 @default.
- W2048482227 cites W2146734921 @default.
- W2048482227 cites W2147496191 @default.
- W2048482227 cites W2165055982 @default.
- W2048482227 doi "https://doi.org/10.1093/ije/dyv050" @default.
- W2048482227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4598798" @default.
- W2048482227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25921222" @default.
- W2048482227 hasPublicationYear "2015" @default.
- W2048482227 type Work @default.
- W2048482227 sameAs 2048482227 @default.
- W2048482227 citedByCount "11" @default.
- W2048482227 countsByYear W20484822272015 @default.