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• W2048486542 abstract "Calcium channels are essential for excitation‐contraction coupling and muscle development. At the end of fetal life, two types of Ca 2+ currents can be recorded in muscle cells. Whereas L‐type Ca 2+ channels have been extensively studied, T‐type channels have been poorly characterized in skeletal muscle. We describe here the functional and molecular properties of T‐type calcium channels in developing mouse skeletal muscle. The T‐type current density increased transiently during prenatal myogenesis with a maximum at embryonic day E16 followed by a drastic decrease until birth. This current showed similar electrophysiological and pharmacological properties at all examined stages. It displayed a wide window current centred at about −35 and −55 mV in 10 and 2 m m external Ca 2+ , respectively. Activation and inactivation kinetics were fast (3 and 16 ms, respectively). The current was inhibited by nickel and amiloride with an IC 50 of 5.4 and 156 μ m , respectively, values similar to those described for cloned T‐type α 1H channels. Whole muscle tissue RT‐PCR analysis revealed mRNAs corresponding to α 1H and α 1G subunits in the fetus but not in the adult. However, single‐fibre RT‐PCR demonstrated that only α 1H mRNA was present in prenatal fibres, suggesting that the α 1G transcript present in muscle tissue must be expressed by non‐skeletal muscle cells. Altogether, these results demonstrate that the α 1H subunit generates functional T‐type calcium channels in developing skeletal muscle fibres and suggest that these channels are involved in the early stages of muscle differentiation." @default.
• W2048486542 created "2016-06-24" @default.
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• W2048486542 date "2002-03-01" @default.
• W2048486542 modified "2023-09-25" @default.
• W2048486542 title "α_1H mRNA in single skeletal muscle fibres accounts for T‐type calcium current transient expression during fetal development in mice" @default.
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• W2048486542 doi "https://doi.org/10.1113/jphysiol.2001.013246" @default.
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