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- W2048487537 abstract "Cell migration plays an important role in various biological processes ranging from tissue repair to cancer metastasis. Most of the studies reported so far have investigated cell migration in a 2-D environment. However, recent years have witnessed a surge of interest in understanding migration of cells within 3-D environment recapitulating various attributes of the native environment. To this end, we have developed an approach to study the migratory transition from 2-D to 3-D on Matrigel as a model system to mimic the processes, including matrix degradation, occurring in 3-D migration. Using this system, we characterize the migration capabilities of non-metastatic (MCF-7) and metastatic (MDA-MB-231) breast cancer cells by analyzing (i) the penetration depth into the Matrigel required for plastic deformation of the matrix, (ii) the magnitude and distribution of traction forces generated before the elastic limit of the material. Furthermore, we examine whether the cellular motility between non-metastatic and metastatic cells converge to a similar behavior when the matrix metalloproteinase activity are altered at various levels. The degree of convergence will be determined by again analyzing the required depth for plastic deformation and the magnitude and distribution of traction forces generated before the elastic limit." @default.
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- W2048487537 date "2012-01-01" @default.
- W2048487537 modified "2023-09-27" @default.
- W2048487537 title "Cancer Migration in 3-D Environment" @default.
- W2048487537 doi "https://doi.org/10.1016/j.bpj.2011.11.3833" @default.
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