Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048487789> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2048487789 endingPage "58" @default.
- W2048487789 startingPage "51" @default.
- W2048487789 abstract "Macrophages in the liver (Kupffer cells) can be depleted by a single intravenous injection with liposome encapsulated clodronate, an anionic bisphosphonate or by liposome encapsulated propamidine, a cationic diamidine. In the present study, it was investigated whether the efficacy of the liposome mediated depletion of Kupffer cells could be enhanced by modification of the phospholipid bilayers. The efficacy of liposome mediated depletion was evaluated by comparison of the percentages of ED2-positive Kupffer cells in the rat liver, depleted by the drugs encapsulated in the liposomes at different concentrations. It is demonstrated that anionic control liposomes, containing no drug at all and composed of phosphatidylcholine (PC), phosphatidylserine (PS) and cholesterol (C) in a molar ratio of 3:3:1, reduced the percentage of ED2-positive Kupffer cells in the rat liver to about 20% of their normal numbers. At certain drug concentrations, anionic liposomes are shown to be efficacious carriers for intraphagocytic delivery of clodronate, but not for propamidine. Optimal efficacy of the latter drug was achieved by encapsulation into neutral liposomes. Omission of cholesterol or mannosylation of the phospholipid bilayers did not improve the efficacy when compared to neutral liposomes. At high concentrations of encapsulated drugs, all liposome formulations induced a nearly complete depletion of Kupffer cells (>95%)." @default.
- W2048487789 created "2016-06-24" @default.
- W2048487789 creator A5021982925 @default.
- W2048487789 creator A5079003683 @default.
- W2048487789 date "1998-03-01" @default.
- W2048487789 modified "2023-10-16" @default.
- W2048487789 title "Manipulation of Kupffer cells by liposome encapsulated clodronate and propamidine—synergistic and antagonistic effects of liposomal phospholipids and drugs" @default.
- W2048487789 cites W1608305635 @default.
- W2048487789 cites W1689968641 @default.
- W2048487789 cites W1967021794 @default.
- W2048487789 cites W1975079800 @default.
- W2048487789 cites W1979217419 @default.
- W2048487789 cites W1983565801 @default.
- W2048487789 cites W1985042949 @default.
- W2048487789 cites W1993262247 @default.
- W2048487789 cites W1993677761 @default.
- W2048487789 cites W1999631461 @default.
- W2048487789 cites W2002059065 @default.
- W2048487789 cites W2040328643 @default.
- W2048487789 cites W2051413663 @default.
- W2048487789 cites W2079078912 @default.
- W2048487789 cites W2118437306 @default.
- W2048487789 cites W2133967889 @default.
- W2048487789 cites W2151363901 @default.
- W2048487789 cites W2161859917 @default.
- W2048487789 cites W2179142653 @default.
- W2048487789 cites W2409658494 @default.
- W2048487789 cites W4240210710 @default.
- W2048487789 doi "https://doi.org/10.1016/s0378-5173(97)00412-2" @default.
- W2048487789 hasPublicationYear "1998" @default.
- W2048487789 type Work @default.
- W2048487789 sameAs 2048487789 @default.
- W2048487789 citedByCount "6" @default.
- W2048487789 countsByYear W20484877892013 @default.
- W2048487789 crossrefType "journal-article" @default.
- W2048487789 hasAuthorship W2048487789A5021982925 @default.
- W2048487789 hasAuthorship W2048487789A5079003683 @default.
- W2048487789 hasConcept C13245373 @default.
- W2048487789 hasConcept C185154212 @default.
- W2048487789 hasConcept C185592680 @default.
- W2048487789 hasConcept C203014093 @default.
- W2048487789 hasConcept C2778904781 @default.
- W2048487789 hasConcept C2780035454 @default.
- W2048487789 hasConcept C55493867 @default.
- W2048487789 hasConcept C71924100 @default.
- W2048487789 hasConcept C98274493 @default.
- W2048487789 hasConceptScore W2048487789C13245373 @default.
- W2048487789 hasConceptScore W2048487789C185154212 @default.
- W2048487789 hasConceptScore W2048487789C185592680 @default.
- W2048487789 hasConceptScore W2048487789C203014093 @default.
- W2048487789 hasConceptScore W2048487789C2778904781 @default.
- W2048487789 hasConceptScore W2048487789C2780035454 @default.
- W2048487789 hasConceptScore W2048487789C55493867 @default.
- W2048487789 hasConceptScore W2048487789C71924100 @default.
- W2048487789 hasConceptScore W2048487789C98274493 @default.
- W2048487789 hasIssue "1-2" @default.
- W2048487789 hasLocation W20484877891 @default.
- W2048487789 hasOpenAccess W2048487789 @default.
- W2048487789 hasPrimaryLocation W20484877891 @default.
- W2048487789 hasRelatedWork W1974839444 @default.
- W2048487789 hasRelatedWork W1987401796 @default.
- W2048487789 hasRelatedWork W2020067635 @default.
- W2048487789 hasRelatedWork W2038782216 @default.
- W2048487789 hasRelatedWork W2042019806 @default.
- W2048487789 hasRelatedWork W2090261220 @default.
- W2048487789 hasRelatedWork W2213954051 @default.
- W2048487789 hasRelatedWork W2400461952 @default.
- W2048487789 hasRelatedWork W2991675850 @default.
- W2048487789 hasRelatedWork W4303182829 @default.
- W2048487789 hasVolume "162" @default.
- W2048487789 isParatext "false" @default.
- W2048487789 isRetracted "false" @default.
- W2048487789 magId "2048487789" @default.
- W2048487789 workType "article" @default.