FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048490428> ?p ?o ?g. }

• W2048490428 endingPage "e1002709" @default.
• W2048490428 startingPage "e1002709" @default.
• W2048490428 abstract "Effective T cell responses can decisively influence the outcome of retroviral infection. However, what constitutes protective T cell responses or determines the ability of the host to mount such responses is incompletely understood. Here we studied the requirements for development and induction of CD4+ T cells that were essential for immunity to Friend virus (FV) infection of mice, according to their TCR avidity for an FV-derived epitope. We showed that a self peptide, encoded by an endogenous retrovirus, negatively selected a significant fraction of polyclonal FV-specific CD4+ T cells and diminished the response to FV infection. Surprisingly, however, CD4+ T cell-mediated antiviral activity was fully preserved. Detailed repertoire analysis revealed that clones with low avidity for FV-derived peptides were more cross-reactive with self peptides and were consequently preferentially deleted. Negative selection of low-avidity FV-reactive CD4+ T cells was responsible for the dominance of high-avidity clones in the response to FV infection, suggesting that protection against the primary infecting virus was mediated exclusively by high-avidity CD4+ T cells. Thus, although negative selection reduced the size and cross-reactivity of the available FV-reactive naïve CD4+ T cell repertoire, it increased the overall avidity of the repertoire that responded to infection. These findings demonstrate that self proteins expressed by replication-defective endogenous retroviruses can heavily influence the formation of the TCR repertoire reactive with exogenous retroviruses and determine the avidity of the response to retroviral infection. Given the overabundance of endogenous retroviruses in the human genome, these findings also suggest that endogenous retroviral proteins, presented by products of highly polymorphic HLA alleles, may shape the human TCR repertoire that reacts with exogenous retroviruses or other infecting pathogens, leading to interindividual heterogeneity." @default.
• W2048490428 created "2016-06-24" @default.
• W2048490428 creator A5006500474 @default.
• W2048490428 creator A5011658216 @default.
• W2048490428 creator A5021798689 @default.
• W2048490428 creator A5032023456 @default.
• W2048490428 creator A5058020166 @default.
• W2048490428 creator A5083857819 @default.
• W2048490428 date "2012-05-10" @default.
• W2048490428 modified "2023-09-25" @default.
• W2048490428 title "Negative Selection by an Endogenous Retrovirus Promotes a Higher-Avidity CD4+ T Cell Response to Retroviral Infection" @default.
• W2048490428 cites W1499318095 @default.
• W2048490428 cites W1533753922 @default.
• W2048490428 cites W1613936157 @default.
• W2048490428 cites W1629735417 @default.
• W2048490428 cites W1790788966 @default.
• W2048490428 cites W1964351701 @default.
• W2048490428 cites W1970688528 @default.
• W2048490428 cites W1974920235 @default.
• W2048490428 cites W1976900976 @default.
• W2048490428 cites W1978644615 @default.
• W2048490428 cites W1978699019 @default.
• W2048490428 cites W1979105659 @default.
• W2048490428 cites W1982895831 @default.
• W2048490428 cites W1984682873 @default.
• W2048490428 cites W1992196706 @default.
• W2048490428 cites W1998602982 @default.
• W2048490428 cites W2003051762 @default.
• W2048490428 cites W2015569874 @default.
• W2048490428 cites W2016644556 @default.
• W2048490428 cites W2019757058 @default.
• W2048490428 cites W2037367542 @default.
• W2048490428 cites W2038633253 @default.
• W2048490428 cites W2042718212 @default.
• W2048490428 cites W2050275491 @default.
• W2048490428 cites W2053754255 @default.
• W2048490428 cites W2055579456 @default.
• W2048490428 cites W2056441977 @default.
• W2048490428 cites W2070385154 @default.
• W2048490428 cites W2070704255 @default.
• W2048490428 cites W2073465064 @default.
• W2048490428 cites W2073740636 @default.
• W2048490428 cites W2079777665 @default.
• W2048490428 cites W2082712562 @default.
• W2048490428 cites W2083308088 @default.
• W2048490428 cites W2085607976 @default.
• W2048490428 cites W2085831528 @default.
• W2048490428 cites W2089237841 @default.
• W2048490428 cites W2097336904 @default.
• W2048490428 cites W2101762554 @default.
• W2048490428 cites W2103780522 @default.
• W2048490428 cites W2107219546 @default.
• W2048490428 cites W2107277218 @default.
• W2048490428 cites W2107831615 @default.
• W2048490428 cites W2109130469 @default.
• W2048490428 cites W2111078616 @default.
• W2048490428 cites W2111900261 @default.
• W2048490428 cites W2120721384 @default.
• W2048490428 cites W2123584222 @default.
• W2048490428 cites W2124907015 @default.
• W2048490428 cites W2134173374 @default.
• W2048490428 cites W2137879329 @default.
• W2048490428 cites W2140489687 @default.
• W2048490428 cites W2142644198 @default.
• W2048490428 cites W2143888124 @default.
• W2048490428 cites W2144890743 @default.
• W2048490428 cites W2150171130 @default.
• W2048490428 cites W2152856116 @default.
• W2048490428 cites W2153332609 @default.
• W2048490428 cites W2157051716 @default.
• W2048490428 cites W2157279932 @default.
• W2048490428 cites W2160822369 @default.
• W2048490428 cites W2165773016 @default.
• W2048490428 cites W2166122762 @default.
• W2048490428 cites W2169193331 @default.
• W2048490428 cites W4248069309 @default.
• W2048490428 doi "https://doi.org/10.1371/journal.ppat.1002709" @default.
• W2048490428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3349761" @default.
• W2048490428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22589728" @default.
• W2048490428 hasPublicationYear "2012" @default.
• W2048490428 type Work @default.
• W2048490428 sameAs 2048490428 @default.
• W2048490428 citedByCount "48" @default.
• W2048490428 countsByYear W20484904282012 @default.
• W2048490428 countsByYear W20484904282013 @default.
• W2048490428 countsByYear W20484904282014 @default.
• W2048490428 countsByYear W20484904282015 @default.
• W2048490428 countsByYear W20484904282016 @default.
• W2048490428 countsByYear W20484904282017 @default.
• W2048490428 countsByYear W20484904282018 @default.
• W2048490428 countsByYear W20484904282019 @default.
• W2048490428 countsByYear W20484904282020 @default.
• W2048490428 countsByYear W20484904282021 @default.
• W2048490428 countsByYear W20484904282022 @default.
• W2048490428 countsByYear W20484904282023 @default.
• W2048490428 crossrefType "journal-article" @default.
• W2048490428 hasAuthorship W2048490428A5006500474 @default.
• W2048490428 hasAuthorship W2048490428A5011658216 @default.

• next