FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048491412> ?p ?o ?g. }

• W2048491412 endingPage "2431" @default.
• W2048491412 startingPage "2423" @default.
• W2048491412 abstract "Abstract The sequence of coagulant reactions in vivo following vascular injury is poorly characterized. Using quantitative immunoassays, the time courses were evaluated for activation of prothrombin, factor (F)V, FXIII, fibrinogen (Fbg) cleavage, and FVa inactivation in bleeding-time blood collected at 30-second intervals from 12 healthy subjects both before and after aspirin ingestion. Prothrombin decreased at a maximum rate of 14.2 ± 0.6 nM per second to 10% of initial values at the end of bleeding. Significant amounts of α-thrombin B chain appeared rapidly at 90 seconds of bleeding and increased at a maximum rate of 0.224 ± 0.03 nM per second to a peak value of 38 nM. Kinetics of prethrombin 2 generation was almost identical. Prothrombinase concentration reached a peak value of 22 pM at 150 seconds and then decreased to 9 pM at the end of bleeding. Prothrombin fragment 1.2 (F1.2) was produced explosively (0.673 ± 0.05 nM per second), whereas thrombin-antithrombin III (TAT) complexes were generated at a much slower rate (0.11 ± 0.008 nM per second;P = .002). FVa light chain was detectable 30 seconds later than the heavy chain (150 seconds) and was produced at a slightly slower rate (0.027 ± 0.001 nM per second) when compared with the heavy chain (0.032 ± 0.002 nM per second; P = .041). The 30 000 fragment (residues 307-506) of FVa heavy chain produced by activated protein C appeared as early as at 90 seconds and increased with time. Fbg was removed from the blood shed with a high rate of 0.047 ± 0.02 μM/s and became undetectable at approximately 180 seconds of bleeding. The velocity of FXIII activation correlated with thrombin B-chain formation. A 7-day aspirin administration (75 mg/d) resulted in significant reductions in maximum rates of (1) prothrombin removal (by 29%; P = .008); generation of α-thrombin B-chain (by 27.2%; P = .022), and prethrombin 2 (by 26%; P = .014); formation of F1.2 (by 31.4%;P = .009) and TAT (by 30.3%; P = 0.013); (2) release of FVa heavy chain (by 25%; P = .003) and FVa light chain (by 29.6%; P = .007); (3) Fbg depletion from solution (by 30.5%; P = .002); and (4) FXIII activation (by 28.6%; P = .003). Total amounts of the proteins studied, collected at every interval, also significantly decreased following aspirin ingestion. These results indicate that low-dose aspirin impairs thrombin generation and reactions catalyzed by this enzyme at the site of the injury." @default.
• W2048491412 created "2016-06-24" @default.
• W2048491412 creator A5017061318 @default.
• W2048491412 creator A5047958060 @default.
• W2048491412 creator A5048931249 @default.
• W2048491412 creator A5065094545 @default.
• W2048491412 creator A5075389112 @default.
• W2048491412 date "2001-10-15" @default.
• W2048491412 modified "2023-09-30" @default.
• W2048491412 title "Blood coagulation at the site of microvascular injury: effects of low-dose aspirin" @default.
• W2048491412 cites W13793788 @default.
• W2048491412 cites W1483922672 @default.
• W2048491412 cites W1489050099 @default.
• W2048491412 cites W1489758714 @default.
• W2048491412 cites W1531124972 @default.
• W2048491412 cites W1540403899 @default.
• W2048491412 cites W1541901307 @default.
• W2048491412 cites W1583037972 @default.
• W2048491412 cites W1605579668 @default.
• W2048491412 cites W1846683055 @default.
• W2048491412 cites W187459506 @default.
• W2048491412 cites W193457800 @default.
• W2048491412 cites W1965222750 @default.
• W2048491412 cites W1966404014 @default.
• W2048491412 cites W1973687787 @default.
• W2048491412 cites W1973829957 @default.
• W2048491412 cites W1974956610 @default.
• W2048491412 cites W1979742792 @default.
• W2048491412 cites W1979862980 @default.
• W2048491412 cites W1997521359 @default.
• W2048491412 cites W2003715783 @default.
• W2048491412 cites W2012788627 @default.
• W2048491412 cites W2021870770 @default.
• W2048491412 cites W2034417156 @default.
• W2048491412 cites W2034770905 @default.
• W2048491412 cites W2036005064 @default.
• W2048491412 cites W2041361662 @default.
• W2048491412 cites W2043614295 @default.
• W2048491412 cites W2044880765 @default.
• W2048491412 cites W2046007480 @default.
• W2048491412 cites W2051039082 @default.
• W2048491412 cites W2071540164 @default.
• W2048491412 cites W207762209 @default.
• W2048491412 cites W2088598503 @default.
• W2048491412 cites W2088930618 @default.
• W2048491412 cites W2100837269 @default.
• W2048491412 cites W2101108802 @default.
• W2048491412 cites W2110446672 @default.
• W2048491412 cites W2124925382 @default.
• W2048491412 cites W2150612971 @default.
• W2048491412 cites W2331216347 @default.
• W2048491412 cites W2402324425 @default.
• W2048491412 cites W2415757482 @default.
• W2048491412 cites W244306418 @default.
• W2048491412 cites W342169260 @default.
• W2048491412 cites W40883435 @default.
• W2048491412 cites W4236219737 @default.
• W2048491412 cites W4250512610 @default.
• W2048491412 cites W74287153 @default.
• W2048491412 doi "https://doi.org/10.1182/blood.v98.8.2423" @default.
• W2048491412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11588039" @default.
• W2048491412 hasPublicationYear "2001" @default.
• W2048491412 type Work @default.
• W2048491412 sameAs 2048491412 @default.
• W2048491412 citedByCount "84" @default.
• W2048491412 countsByYear W20484914122012 @default.
• W2048491412 countsByYear W20484914122013 @default.
• W2048491412 countsByYear W20484914122014 @default.
• W2048491412 countsByYear W20484914122015 @default.
• W2048491412 countsByYear W20484914122016 @default.
• W2048491412 countsByYear W20484914122017 @default.
• W2048491412 countsByYear W20484914122018 @default.
• W2048491412 countsByYear W20484914122019 @default.
• W2048491412 countsByYear W20484914122020 @default.
• W2048491412 countsByYear W20484914122021 @default.
• W2048491412 countsByYear W20484914122023 @default.
• W2048491412 crossrefType "journal-article" @default.
• W2048491412 hasAuthorship W2048491412A5017061318 @default.
• W2048491412 hasAuthorship W2048491412A5047958060 @default.
• W2048491412 hasAuthorship W2048491412A5048931249 @default.
• W2048491412 hasAuthorship W2048491412A5065094545 @default.
• W2048491412 hasAuthorship W2048491412A5075389112 @default.
• W2048491412 hasBestOaLocation W20484914121 @default.
• W2048491412 hasConcept C112516734 @default.
• W2048491412 hasConcept C126322002 @default.
• W2048491412 hasConcept C150903083 @default.
• W2048491412 hasConcept C185592680 @default.
• W2048491412 hasConcept C207001950 @default.
• W2048491412 hasConcept C2777292125 @default.
• W2048491412 hasConcept C2777557582 @default.
• W2048491412 hasConcept C2777628954 @default.
• W2048491412 hasConcept C2778261982 @default.
• W2048491412 hasConcept C2778382381 @default.
• W2048491412 hasConcept C2779026020 @default.
• W2048491412 hasConcept C2779036427 @default.
• W2048491412 hasConcept C2779216453 @default.
• W2048491412 hasConcept C2780077467 @default.
• W2048491412 hasConcept C2780434524 @default.

• next