FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048502835> ?p ?o ?g. }

• W2048502835 endingPage "3538" @default.
• W2048502835 startingPage "3523" @default.
• W2048502835 abstract "Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis. To explore their structure-antitrypanosomal activity relationships, a set of 34 natural and semi-synthetic STLs and amino-STLs was tested in vitro against T. b. rhodesiense (which causes East African sleeping sickness) and mammalian cancer cells (rat bone myoblast L6 cells). It was found that the α-methylene-γ-lactone moiety is necessary for both antitrypanosomal effects and cytotoxicity. Antitrypanosomal selectivity is facilitated by 2-(hydroxymethyl)acrylate or 3,4-dihydroxy-2-methylenebutylate side chains, and by the presence of cyclopentenone rings. Semi-synthetic STL amines with morpholino and dimethylamino groups showed improved in vitro activity over the native STLs. The dimethylamino derivative of cynaropicrin was prepared and tested orally in the T. b. rhodesiense acute mouse model, where it showed reduced toxicity over cynaropicrin, but also lost antitrypanosomal activity." @default.
• W2048502835 created "2016-06-24" @default.
• W2048502835 creator A5008586187 @default.
• W2048502835 creator A5020155948 @default.
• W2048502835 creator A5034350830 @default.
• W2048502835 creator A5034651641 @default.
• W2048502835 creator A5036908706 @default.
• W2048502835 creator A5048510789 @default.
• W2048502835 creator A5052192433 @default.
• W2048502835 creator A5074424544 @default.
• W2048502835 creator A5084123396 @default.
• W2048502835 creator A5084959196 @default.
• W2048502835 creator A5086288067 @default.
• W2048502835 date "2014-03-21" @default.
• W2048502835 modified "2023-10-18" @default.
• W2048502835 title "Structure-Activity Relationship Study of Sesquiterpene Lactones and Their Semi-Synthetic Amino Derivatives as Potential Antitrypanosomal Products" @default.
• W2048502835 cites W1967086390 @default.
• W2048502835 cites W1974741353 @default.
• W2048502835 cites W1986834345 @default.
• W2048502835 cites W1987565779 @default.
• W2048502835 cites W2004990917 @default.
• W2048502835 cites W2020086312 @default.
• W2048502835 cites W2040101825 @default.
• W2048502835 cites W2043765788 @default.
• W2048502835 cites W2045111362 @default.
• W2048502835 cites W2053575847 @default.
• W2048502835 cites W2064926341 @default.
• W2048502835 cites W2075381413 @default.
• W2048502835 cites W2127063113 @default.
• W2048502835 cites W2135983047 @default.
• W2048502835 cites W2145367956 @default.
• W2048502835 cites W2151877638 @default.
• W2048502835 cites W2328682655 @default.
• W2048502835 cites W4239568869 @default.
• W2048502835 doi "https://doi.org/10.3390/molecules19033523" @default.
• W2048502835 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6271975" @default.
• W2048502835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24662071" @default.
• W2048502835 hasPublicationYear "2014" @default.
• W2048502835 type Work @default.
• W2048502835 sameAs 2048502835 @default.
• W2048502835 citedByCount "34" @default.
• W2048502835 countsByYear W20485028352015 @default.
• W2048502835 countsByYear W20485028352016 @default.
• W2048502835 countsByYear W20485028352017 @default.
• W2048502835 countsByYear W20485028352018 @default.
• W2048502835 countsByYear W20485028352019 @default.
• W2048502835 countsByYear W20485028352020 @default.
• W2048502835 countsByYear W20485028352021 @default.
• W2048502835 countsByYear W20485028352022 @default.
• W2048502835 countsByYear W20485028352023 @default.
• W2048502835 crossrefType "journal-article" @default.
• W2048502835 hasAuthorship W2048502835A5008586187 @default.
• W2048502835 hasAuthorship W2048502835A5020155948 @default.
• W2048502835 hasAuthorship W2048502835A5034350830 @default.
• W2048502835 hasAuthorship W2048502835A5034651641 @default.
• W2048502835 hasAuthorship W2048502835A5036908706 @default.
• W2048502835 hasAuthorship W2048502835A5048510789 @default.
• W2048502835 hasAuthorship W2048502835A5052192433 @default.
• W2048502835 hasAuthorship W2048502835A5074424544 @default.
• W2048502835 hasAuthorship W2048502835A5084123396 @default.
• W2048502835 hasAuthorship W2048502835A5084959196 @default.
• W2048502835 hasAuthorship W2048502835A5086288067 @default.
• W2048502835 hasBestOaLocation W20485028351 @default.
• W2048502835 hasConcept C109316439 @default.
• W2048502835 hasConcept C177756618 @default.
• W2048502835 hasConcept C185592680 @default.
• W2048502835 hasConcept C18903297 @default.
• W2048502835 hasConcept C193042331 @default.
• W2048502835 hasConcept C202751555 @default.
• W2048502835 hasConcept C2776211264 @default.
• W2048502835 hasConcept C2776568683 @default.
• W2048502835 hasConcept C2776612806 @default.
• W2048502835 hasConcept C2777903533 @default.
• W2048502835 hasConcept C2779243328 @default.
• W2048502835 hasConcept C2779578577 @default.
• W2048502835 hasConcept C2780591741 @default.
• W2048502835 hasConcept C55493867 @default.
• W2048502835 hasConcept C71240020 @default.
• W2048502835 hasConcept C86803240 @default.
• W2048502835 hasConceptScore W2048502835C109316439 @default.
• W2048502835 hasConceptScore W2048502835C177756618 @default.
• W2048502835 hasConceptScore W2048502835C185592680 @default.
• W2048502835 hasConceptScore W2048502835C18903297 @default.
• W2048502835 hasConceptScore W2048502835C193042331 @default.
• W2048502835 hasConceptScore W2048502835C202751555 @default.
• W2048502835 hasConceptScore W2048502835C2776211264 @default.
• W2048502835 hasConceptScore W2048502835C2776568683 @default.
• W2048502835 hasConceptScore W2048502835C2776612806 @default.
• W2048502835 hasConceptScore W2048502835C2777903533 @default.
• W2048502835 hasConceptScore W2048502835C2779243328 @default.
• W2048502835 hasConceptScore W2048502835C2779578577 @default.
• W2048502835 hasConceptScore W2048502835C2780591741 @default.
• W2048502835 hasConceptScore W2048502835C55493867 @default.
• W2048502835 hasConceptScore W2048502835C71240020 @default.
• W2048502835 hasConceptScore W2048502835C86803240 @default.
• W2048502835 hasIssue "3" @default.
• W2048502835 hasLocation W20485028351 @default.
• W2048502835 hasLocation W20485028352 @default.

• next