Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048509938> ?p ?o ?g. }
- W2048509938 endingPage "372" @default.
- W2048509938 startingPage "357" @default.
- W2048509938 abstract "The effects of the indolehallucinogen psilocybin, a mixed 5-HT2 and 5-HT1 agonist, on regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET and [F-18]-fluorodeoxyglucose (FDG) prior to and following a 15- or 20-mg dose of psilocybin. Psychotomimetic doses of psilocybin were found to produce a global increase in cerebral metabolic rate of glucose (CMRglu) with significant and most marked increases in the frontomedial and frontolateral cortex (24.3%), anterior cingulate (24.9%), and temporomedial cortex (25.3%). Somewhat smaller increases of CMRglu were found in the basal ganglia (18.5%), and the smallest increases were found in the sensorimotor (14.7%) and occipital cortex (14.4%). The increases of CMRglu in the prefrontal cortex, anterior cingulate, temporomedial cortex, and putamen correlated positively with psychotic symptom formation, in particular with hallucinatory ego disintegration. The present data suggest that excessive 5-HT2 receptor activation results in a hyperfrontal metablic pattern that parallels comparable metabolic findings associated with acute psychotic episodes in chronic schizophrenics and contrasts with the hypofrontality in chronic schizophrenic patients." @default.
- W2048509938 created "2016-06-24" @default.
- W2048509938 creator A5043773976 @default.
- W2048509938 creator A5063133386 @default.
- W2048509938 creator A5065698750 @default.
- W2048509938 creator A5066198405 @default.
- W2048509938 creator A5083635288 @default.
- W2048509938 creator A5086400032 @default.
- W2048509938 date "1997-05-01" @default.
- W2048509938 modified "2023-10-17" @default.
- W2048509938 title "Positron Emission Tomography and Fluorodeoxyglucose Studies of Metabolic Hyperfrontality and Psychopathology in the Psilocybin Model of Psychosis" @default.
- W2048509938 cites W1239326550 @default.
- W2048509938 cites W146248421 @default.
- W2048509938 cites W1526029238 @default.
- W2048509938 cites W1891469620 @default.
- W2048509938 cites W1933205484 @default.
- W2048509938 cites W1941333815 @default.
- W2048509938 cites W1965567101 @default.
- W2048509938 cites W1966592369 @default.
- W2048509938 cites W1968309545 @default.
- W2048509938 cites W1968517715 @default.
- W2048509938 cites W1976195294 @default.
- W2048509938 cites W1979056208 @default.
- W2048509938 cites W1982599131 @default.
- W2048509938 cites W1985997266 @default.
- W2048509938 cites W1988918395 @default.
- W2048509938 cites W1992538914 @default.
- W2048509938 cites W1992795970 @default.
- W2048509938 cites W1993527031 @default.
- W2048509938 cites W1998276762 @default.
- W2048509938 cites W2000021284 @default.
- W2048509938 cites W2001310902 @default.
- W2048509938 cites W2008028078 @default.
- W2048509938 cites W2009798253 @default.
- W2048509938 cites W2013755742 @default.
- W2048509938 cites W2015390545 @default.
- W2048509938 cites W2021099633 @default.
- W2048509938 cites W2024256650 @default.
- W2048509938 cites W2024261524 @default.
- W2048509938 cites W2027535369 @default.
- W2048509938 cites W2028308920 @default.
- W2048509938 cites W2031607959 @default.
- W2048509938 cites W2032540534 @default.
- W2048509938 cites W2034290472 @default.
- W2048509938 cites W2034894507 @default.
- W2048509938 cites W2039377493 @default.
- W2048509938 cites W2043768758 @default.
- W2048509938 cites W2047879345 @default.
- W2048509938 cites W2048789521 @default.
- W2048509938 cites W2051699581 @default.
- W2048509938 cites W2051883007 @default.
- W2048509938 cites W2052470410 @default.
- W2048509938 cites W2057689326 @default.
- W2048509938 cites W2060747105 @default.
- W2048509938 cites W2061506859 @default.
- W2048509938 cites W2061794744 @default.
- W2048509938 cites W2061857355 @default.
- W2048509938 cites W2062646524 @default.
- W2048509938 cites W2064542914 @default.
- W2048509938 cites W2074225517 @default.
- W2048509938 cites W2080564246 @default.
- W2048509938 cites W2082156867 @default.
- W2048509938 cites W2087447249 @default.
- W2048509938 cites W2090203522 @default.
- W2048509938 cites W2092855120 @default.
- W2048509938 cites W2093533413 @default.
- W2048509938 cites W2094777862 @default.
- W2048509938 cites W2103320997 @default.
- W2048509938 cites W2104155521 @default.
- W2048509938 cites W2108585495 @default.
- W2048509938 cites W2112911894 @default.
- W2048509938 cites W2122257284 @default.
- W2048509938 cites W2128426997 @default.
- W2048509938 cites W2130777724 @default.
- W2048509938 cites W2133462240 @default.
- W2048509938 cites W2141244106 @default.
- W2048509938 cites W2155222763 @default.
- W2048509938 cites W2156761163 @default.
- W2048509938 cites W2158648681 @default.
- W2048509938 cites W2163563718 @default.
- W2048509938 cites W2164303115 @default.
- W2048509938 cites W2166094975 @default.
- W2048509938 cites W2166486417 @default.
- W2048509938 cites W2169365717 @default.
- W2048509938 cites W2169490712 @default.
- W2048509938 cites W224070021 @default.
- W2048509938 cites W2245706386 @default.
- W2048509938 cites W2337133080 @default.
- W2048509938 cites W2396844307 @default.
- W2048509938 cites W2409543570 @default.
- W2048509938 cites W2412554478 @default.
- W2048509938 cites W2412704513 @default.
- W2048509938 cites W2414362583 @default.
- W2048509938 cites W2471523186 @default.
- W2048509938 cites W2472643432 @default.
- W2048509938 cites W284042030 @default.
- W2048509938 cites W2894668610 @default.
- W2048509938 cites W2922915278 @default.