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- W2048522089 abstract "Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C 18 column (5 μm, 250 mm×4.6 mm id) using fluorescence detection with λ ex =276 nm and λ em =296 nm. The mobile phase consists of methanol–water (50:50, v/v) containing 0.1% TFA. The analysis was performed in less than 10 min with a flow rate of 1 mL/min. The assay was linear over the concentration range of 3 – 200 and 5 – 300 ng/mL for plasma and urine, respectively. The LOD were 1.0 and 1.5 ng/mL for plasma and urine, respectively. The LOQ were 3.0 and 5.0 ng/mL for plasma and urine, respectively. The extraction recoveries were found to be 95.6 ± 1.53 and 96.4 ± 1.75% for plasma and urine, respectively. Also, the method was successfully applied to three patients with hypertension who had been given an oral tablet of 100 mg metoprolol." @default.
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- W2048522089 date "2010-06-28" @default.
- W2048522089 modified "2023-10-18" @default.
- W2048522089 title "Determination of metoprolol in human plasma and urine by high-performance liquid chromatography with fluorescence detection" @default.
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- W2048522089 doi "https://doi.org/10.1002/jssc.201000136" @default.
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