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- W2048543349 abstract "Abstract Isosorbide-5-mononitrate and isosorbide-2-mononitrate, the metabolites of isosorbide dinitrate, were studied for their effects on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of guinea-pig and dog. Isosorbide-5-mononitrate at all concentrations tested and isosorbide-2-mononitrate at low concentrations did not produce significant changes in the mechanical activity of guinea-pig heart preparations. Isosorbide-2-mononitrate in concentrations above 10−4 m inhibited the contractility and shortened the action potential of guinea-pig and dog heart muscle. Neither mononitrate had an effect on cAMP concentration but both induced a significant elevation of cGMP content in guinea-pig heart tissue, the effect of isosorbide-2-mononitrate being greater." @default.
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- W2048543349 date "1992-08-01" @default.
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- W2048543349 title "Effects of Isosorbide-5-mononitrate and Isosorbide-2-mononitrate on the Contractile and Electrical Activity and on the Content of Cyclic Nucleotides in Isolated Heart Muscles of the Guinea-pig and Dog" @default.
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- W2048543349 doi "https://doi.org/10.1111/j.2042-7158.1992.tb05490.x" @default.
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