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- W2048546316 abstract "Individuals with sickle cell disease (SCD) demonstrate an increased susceptibility to invasive bacterial infections (IBI). The most common organisms causing IBI are Streptococcus pneumoniae, nontyphi Salmonella species and Haemophilus influenzae type b (Hib). IBI are the most common causes of death in children below 5 years of age with SCD. Increased susceptibility to IBI is because of several factors including dysfunctional antibody production and opsonophagocytosis as well as defective splenic clearance. Early diagnosis of Hib and pneumococcal infections combined with antibiotic prophylaxis and immunization programs, could lead to significant improvements in mortality, especially in Africa." @default.
- W2048546316 created "2016-06-24" @default.
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- W2048546316 date "2010-03-15" @default.
- W2048546316 modified "2023-10-06" @default.
- W2048546316 title "Susceptibility to invasive bacterial infections in children with sickle cell disease" @default.
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- W2048546316 doi "https://doi.org/10.1002/pbc.22461" @default.
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