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- W2048546936 abstract "Abstract Previous studies have shown that T cells, which are genetically deficient in CTLA-4/CD152 expression, will proliferate uncontrollably, resulting in lethal autoimmune disease. This and other evidence indicate that CTLA-4 plays a critical role in the negative regulation of effector T cell function. In contrast to expectations, BrdU incorporation experiments demonstrated that CTLA-4 expression was associated with normal or even enhanced in vivo proliferation of virus-specific CD4+ and CD8+ T cells following acute lymphocytic choriomeningitis virus or vaccinia virus infection. When compared with CTLA-4– T cells directly ex vivo, CTLA-4+ T cells also exhibited normal antiviral effector functions following stimulation with peptide-coated cells, virus-infected cells, plate-bound anti-CD3/anti-CTLA-4, or the cytokines IL-12 and IL-18. Together, this indicates that CTLA-4 does not directly inhibit antivral T cell expansion or T cell effector functions, at least not under the normal physiological conditions associated with either of these two acute viral infections." @default.
- W2048546936 created "2016-06-24" @default.
- W2048546936 creator A5017436521 @default.
- W2048546936 creator A5041807708 @default.
- W2048546936 date "2007-01-10" @default.
- W2048546936 modified "2023-10-15" @default.
- W2048546936 title "Pivotal Advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection" @default.
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- W2048546936 doi "https://doi.org/10.1189/jlb.0806535" @default.
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