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- W2048552616 abstract "The fru4 allele of the sex determination gene fruitless is induced by insertion of a P[lacZ,ry+] enhancer trap element. This insert also acts to disrupt expression of the fru P1 promoter derived male-specific proteins, consequently impairing male courtship behavior. fru4 maps less than 2 kb upstream of the fru P3 promoter, whose function is essential for viability. We replaced this insert with a GAL4 element, P[GAL4,w+], recovering two lines with insertions in opposite orientations at the locus, one of which demonstrated fru-specific mutant phenotypes. Reporter expression of these lines recapitulated that of P3- and P4-derived proteins which, when correlated with a developmental and tissue specific survey of fru promoters' activities, uncovered a previously unsuspected complexity of fru regulation. These novel fru alleles provide the tools for manipulation of fru-expressing cells, allowing the consequent effects to be related back to specific fru functions and the regulatory units controlling these activities." @default.
- W2048552616 created "2016-06-24" @default.
- W2048552616 creator A5026703392 @default.
- W2048552616 creator A5074382791 @default.
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- W2048552616 date "2005-01-01" @default.
- W2048552616 modified "2023-09-27" @default.
- W2048552616 title "GAL4 enhancer trap targeting of theDrosophila sex determination genefruitless" @default.
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- W2048552616 doi "https://doi.org/10.1002/gene.20143" @default.
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