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• W2048574106 abstract "Activity-induced neurogenesis via Ca2+ entry may be important for establishing Hebbian neural network. However, it remains unclear whether intracellular Ca2+ mobilization is required and which subtypes of Ca2+ release channels expressed in Ca2+ store organelles are involved in the activity-dependent neurogenesis. Here, we demonstrated that the activity of intracellular Ca2+ signaling, expression of neuronal transcription factor NeuroD, and the rate of neurogenesis were significantly inhibited in neuronal cells derived from embryonic stem (ES) cells deficient in the Ca2+ release channel type 2 ryanodine receptors (RyR2−/−). In wild-type (RyR2+/+) but not in RyR2−/− ES cells, activation of L-type Ca2+ channels, GABAA receptors, or RyRs promoted neuronal differentiation, while inhibition of these channels/receptors had an opposite effect. Moreover, neuronal differentiation promoted by activation of GABAA receptors or L-type Ca2+ channels in RyR2+/+ cells was prevented by RyR inhibitors. No significant difference was detected in the expression level of GABAA receptors and L-type channels between neuronal cells derived from two types of ES cells. Thus, activity-induced Ca2+ influx through L-type Ca2+ channels alone is not sufficient in promoting neurogenesis. Instead, an intimate cooperation of L-type Ca2+ channels with RyR2 is crucial for the activity-dependent neurogenesis induced by paracrine and/or autocrine GABA signaling." @default.
• W2048574106 created "2016-06-24" @default.
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• W2048574106 date "2008-05-01" @default.
• W2048574106 modified "2023-09-23" @default.
• W2048574106 title "Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells" @default.
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• W2048574106 doi "https://doi.org/10.1016/j.ceca.2007.07.006" @default.
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• W2048574106 hasPublicationYear "2008" @default.
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