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- W2048574518 abstract "The action of an anti-alpha 1-AGP antibody on AMLR, anti-T3 and PHA T-lymphocyte proliferative response was evaluated. We observed a strong dose-dependent inhibition on T-lymphocyte proliferative responsiveness to autologous non-T cells and to anti-T3 stimulus, whereas PHA activation was unaffected. A lower degree of inhibition of the proliferative response was also observed on pretreating both T and non-T cells with the antibody; the addition of anti-alpha 1-AGP in the culture containing cells pretreated with the antibody showed a further inhibition of thymidine incorporation. The data suggest a direct influence of the antibody on membrane alpha 1-AGP and support a positive role of this glycoprotein (distinct from Ia and T3 antigens) on both anti-T3 and autologous non-T cell T-lymphocyte responsiveness, thus indicating the involvement of alpha 1-AGP in the T3-Ti antigen-specific pathway of T-cell activation." @default.
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- W2048574518 date "1986-11-01" @default.
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- W2048574518 title "Inhibitory effect of an antibody against alpha1-acid glycoprotein (α1-AGP) on autologous mixed lymphocyte reaction and anti-T3 T-lymphocyte activation" @default.
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- W2048574518 doi "https://doi.org/10.1016/0008-8749(86)90068-7" @default.
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