FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048577371> ?p ?o ?g. }

• W2048577371 endingPage "187" @default.
• W2048577371 startingPage "181" @default.
• W2048577371 abstract "Recent reports have linked the expression of specific microRNAs (miRNAs) with tumorigenesis and metastasis. Here, we show that microRNA (miR)-16, which is expressed at lower levels in prostate cancer cells, affects the proliferation of human prostate cancer cell lines both in vitro and in vivo. Transient transfection with synthetic miR-16 significantly reduced cell proliferation of 22Rv1, Du145, PPC-1, and PC-3M-luc cells. A prostate cancer xenograft model revealed that atelocollagen could efficiently deliver synthetic miR-16 to tumor cells on bone tissues in mice when injected into tail veins. In the therapeutic bone metastasis model, injection of miR-16 with atelocollagen via tail vein significantly inhibited the growth of prostate tumors in bone. Cell model studies indicate that miR-16 likely suppresses prostate tumor growth by regulating the expression of genes such as CDK1 and CDK2 associated with cell-cycle control and cellular proliferation. There is a trend toward lower miR-16 expression in human prostate tumors versus normal prostate tissues. Thus, this study indicates the therapeutic potential of miRNA in an animal model of cancer metastasis with systemic miRNA injection and suggest that systemic delivery of miR-16 could be used to treat patients with advanced prostate cancer." @default.
• W2048577371 created "2016-06-24" @default.
• W2048577371 creator A5006406850 @default.
• W2048577371 creator A5017837826 @default.
• W2048577371 creator A5031057165 @default.
• W2048577371 creator A5033310099 @default.
• W2048577371 creator A5039512464 @default.
• W2048577371 creator A5040484422 @default.
• W2048577371 creator A5041282799 @default.
• W2048577371 creator A5051355971 @default.
• W2048577371 creator A5054073408 @default.
• W2048577371 creator A5063479112 @default.
• W2048577371 creator A5086967072 @default.
• W2048577371 date "2010-01-01" @default.
• W2048577371 modified "2023-10-17" @default.
• W2048577371 title "Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes" @default.
• W2048577371 cites W130267474 @default.
• W2048577371 cites W1963691340 @default.
• W2048577371 cites W1978337436 @default.
• W2048577371 cites W1985563073 @default.
• W2048577371 cites W1995443324 @default.
• W2048577371 cites W2072303914 @default.
• W2048577371 cites W2073543802 @default.
• W2048577371 cites W2075329854 @default.
• W2048577371 cites W2083381199 @default.
• W2048577371 cites W2098318517 @default.
• W2048577371 cites W2104610341 @default.
• W2048577371 cites W2104985090 @default.
• W2048577371 cites W2112962172 @default.
• W2048577371 cites W2122683221 @default.
• W2048577371 cites W2130979840 @default.
• W2048577371 cites W2132194692 @default.
• W2048577371 cites W2135314242 @default.
• W2048577371 cites W2135810600 @default.
• W2048577371 cites W2136912778 @default.
• W2048577371 cites W2142221925 @default.
• W2048577371 cites W2144038313 @default.
• W2048577371 cites W2150536104 @default.
• W2048577371 cites W2152091242 @default.
• W2048577371 cites W2160968516 @default.
• W2048577371 cites W2165674132 @default.
• W2048577371 cites W4252025818 @default.
• W2048577371 cites W4294216483 @default.
• W2048577371 doi "https://doi.org/10.1038/mt.2009.207" @default.
• W2048577371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2839211" @default.
• W2048577371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19738602" @default.
• W2048577371 hasPublicationYear "2010" @default.
• W2048577371 type Work @default.
• W2048577371 sameAs 2048577371 @default.
• W2048577371 citedByCount "390" @default.
• W2048577371 countsByYear W20485773712012 @default.
• W2048577371 countsByYear W20485773712013 @default.
• W2048577371 countsByYear W20485773712014 @default.
• W2048577371 countsByYear W20485773712015 @default.
• W2048577371 countsByYear W20485773712016 @default.
• W2048577371 countsByYear W20485773712017 @default.
• W2048577371 countsByYear W20485773712018 @default.
• W2048577371 countsByYear W20485773712019 @default.
• W2048577371 countsByYear W20485773712020 @default.
• W2048577371 countsByYear W20485773712021 @default.
• W2048577371 countsByYear W20485773712022 @default.
• W2048577371 countsByYear W20485773712023 @default.
• W2048577371 crossrefType "journal-article" @default.
• W2048577371 hasAuthorship W2048577371A5006406850 @default.
• W2048577371 hasAuthorship W2048577371A5017837826 @default.
• W2048577371 hasAuthorship W2048577371A5031057165 @default.
• W2048577371 hasAuthorship W2048577371A5033310099 @default.
• W2048577371 hasAuthorship W2048577371A5039512464 @default.
• W2048577371 hasAuthorship W2048577371A5040484422 @default.
• W2048577371 hasAuthorship W2048577371A5041282799 @default.
• W2048577371 hasAuthorship W2048577371A5051355971 @default.
• W2048577371 hasAuthorship W2048577371A5054073408 @default.
• W2048577371 hasAuthorship W2048577371A5063479112 @default.
• W2048577371 hasAuthorship W2048577371A5086967072 @default.
• W2048577371 hasBestOaLocation W20485773711 @default.
• W2048577371 hasConcept C104317684 @default.
• W2048577371 hasConcept C121608353 @default.
• W2048577371 hasConcept C126322002 @default.
• W2048577371 hasConcept C127561419 @default.
• W2048577371 hasConcept C145059251 @default.
• W2048577371 hasConcept C2776235491 @default.
• W2048577371 hasConcept C2776438761 @default.
• W2048577371 hasConcept C2777783956 @default.
• W2048577371 hasConcept C2779013556 @default.
• W2048577371 hasConcept C2779723316 @default.
• W2048577371 hasConcept C2780192828 @default.
• W2048577371 hasConcept C29537977 @default.
• W2048577371 hasConcept C502942594 @default.
• W2048577371 hasConcept C54355233 @default.
• W2048577371 hasConcept C55493867 @default.
• W2048577371 hasConcept C555283112 @default.
• W2048577371 hasConcept C62112901 @default.
• W2048577371 hasConcept C71924100 @default.
• W2048577371 hasConcept C86803240 @default.
• W2048577371 hasConceptScore W2048577371C104317684 @default.
• W2048577371 hasConceptScore W2048577371C121608353 @default.
• W2048577371 hasConceptScore W2048577371C126322002 @default.
• W2048577371 hasConceptScore W2048577371C127561419 @default.

• next