FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048578975> ?p ?o ?g. }

• W2048578975 endingPage "100" @default.
• W2048578975 startingPage "83" @default.
• W2048578975 abstract "The serine peptidase neurotrypsin is stored in presynaptic nerve endings and secreted in an inactive zymogenic form by synaptic activity. After activation, which requires activity of postsynaptic NMDA (N-methyl-D-aspartate) receptors, neurotrypsin cleaves the heparan sulfate proteoglycan agrin at active synapses. The resulting C-terminal 22-kDa fragment of agrin induces dendritic filopodia, which are considered to be precursors of new synapses. In the present study, we investigated the role of GAGs (glycosaminoglycans) in the activation of neurotrypsin and neurotrypsin-dependent agrin cleavage. We found binding of neurotrypsin to the GAG side chains of agrin, which in turn enhanced the activation of neurotrypsin by proprotein convertases and resulted in enhanced agrin cleavage. A similar enhancement of neurotrypsin binding to agrin, neurotrypsin activation and agrin cleavage was induced by the four-amino-acid insert at the y splice site of agrin, which is crucial for the formation of a heparin-binding site. Non-agrin GAGs also contributed to binding and activation of neurotrypsin and, thereby, to agrin cleavage, albeit to a lesser extent. Binding of neurotrypsin to cell-surface glycans locally restricts its conversion from zymogen into active peptidase. This provides the molecular foundation for the local action of neurotrypsin at or in the vicinity of its site of synaptic secretion. By its local action at synapses with correlated pre- and post-synaptic activity, the neurotrypsin–agrin system fulfils the requirements for a mechanism serving experience-dependent modification of activated synapses, which is essential for adaptive structural reorganizations of neuronal circuits in the developing and/or adult brain." @default.
• W2048578975 created "2016-06-24" @default.
• W2048578975 creator A5003944792 @default.
• W2048578975 creator A5014750773 @default.
• W2048578975 creator A5025902125 @default.
• W2048578975 creator A5041897619 @default.
• W2048578975 creator A5052038300 @default.
• W2048578975 creator A5060418599 @default.
• W2048578975 creator A5070979311 @default.
• W2048578975 creator A5072962132 @default.
• W2048578975 creator A5079582380 @default.
• W2048578975 creator A5084409378 @default.
• W2048578975 date "2013-06-13" @default.
• W2048578975 modified "2023-10-18" @default.
• W2048578975 title "Zymogen activation of neurotrypsin and neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans" @default.
• W2048578975 cites W142299751 @default.
• W2048578975 cites W1506964027 @default.
• W2048578975 cites W1568178986 @default.
• W2048578975 cites W1963910405 @default.
• W2048578975 cites W1965927192 @default.
• W2048578975 cites W1969109450 @default.
• W2048578975 cites W1973094863 @default.
• W2048578975 cites W1984687779 @default.
• W2048578975 cites W1997654602 @default.
• W2048578975 cites W1997792407 @default.
• W2048578975 cites W1998325637 @default.
• W2048578975 cites W1999330037 @default.
• W2048578975 cites W2004285833 @default.
• W2048578975 cites W2006562777 @default.
• W2048578975 cites W2014779210 @default.
• W2048578975 cites W2032435199 @default.
• W2048578975 cites W2034556079 @default.
• W2048578975 cites W2037569353 @default.
• W2048578975 cites W2040993569 @default.
• W2048578975 cites W2042995205 @default.
• W2048578975 cites W2058443849 @default.
• W2048578975 cites W2066917018 @default.
• W2048578975 cites W2069272506 @default.
• W2048578975 cites W2076836490 @default.
• W2048578975 cites W2077913168 @default.
• W2048578975 cites W2079171445 @default.
• W2048578975 cites W2085524810 @default.
• W2048578975 cites W2089034628 @default.
• W2048578975 cites W2092751827 @default.
• W2048578975 cites W2094393536 @default.
• W2048578975 cites W2096647918 @default.
• W2048578975 cites W2097069930 @default.
• W2048578975 cites W2099377771 @default.
• W2048578975 cites W2099476014 @default.
• W2048578975 cites W2103415764 @default.
• W2048578975 cites W2106585504 @default.
• W2048578975 cites W2108248880 @default.
• W2048578975 cites W2116244315 @default.
• W2048578975 cites W2116875316 @default.
• W2048578975 cites W2131114792 @default.
• W2048578975 cites W2138577310 @default.
• W2048578975 cites W2151251384 @default.
• W2048578975 cites W2163842198 @default.
• W2048578975 cites W2164538541 @default.
• W2048578975 cites W2165012796 @default.
• W2048578975 cites W2413744043 @default.
• W2048578975 cites W4230170474 @default.
• W2048578975 doi "https://doi.org/10.1042/bj20130166" @default.
• W2048578975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23560819" @default.
• W2048578975 hasPublicationYear "2013" @default.
• W2048578975 type Work @default.
• W2048578975 sameAs 2048578975 @default.
• W2048578975 citedByCount "11" @default.
• W2048578975 countsByYear W20485789752014 @default.
• W2048578975 countsByYear W20485789752017 @default.
• W2048578975 countsByYear W20485789752018 @default.
• W2048578975 countsByYear W20485789752019 @default.
• W2048578975 countsByYear W20485789752020 @default.
• W2048578975 countsByYear W20485789752022 @default.
• W2048578975 countsByYear W20485789752023 @default.
• W2048578975 crossrefType "journal-article" @default.
• W2048578975 hasAuthorship W2048578975A5003944792 @default.
• W2048578975 hasAuthorship W2048578975A5014750773 @default.
• W2048578975 hasAuthorship W2048578975A5025902125 @default.
• W2048578975 hasAuthorship W2048578975A5041897619 @default.
• W2048578975 hasAuthorship W2048578975A5052038300 @default.
• W2048578975 hasAuthorship W2048578975A5060418599 @default.
• W2048578975 hasAuthorship W2048578975A5070979311 @default.
• W2048578975 hasAuthorship W2048578975A5072962132 @default.
• W2048578975 hasAuthorship W2048578975A5079582380 @default.
• W2048578975 hasAuthorship W2048578975A5084409378 @default.
• W2048578975 hasConcept C170493617 @default.
• W2048578975 hasConcept C181199279 @default.
• W2048578975 hasConcept C185592680 @default.
• W2048578975 hasConcept C197341189 @default.
• W2048578975 hasConcept C2777265534 @default.
• W2048578975 hasConcept C2778775115 @default.
• W2048578975 hasConcept C2779024559 @default.
• W2048578975 hasConcept C55493867 @default.
• W2048578975 hasConcept C86803240 @default.
• W2048578975 hasConcept C95444343 @default.
• W2048578975 hasConceptScore W2048578975C170493617 @default.
• W2048578975 hasConceptScore W2048578975C181199279 @default.

• next