FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048600925> ?p ?o ?g. }

• W2048600925 endingPage "497" @default.
• W2048600925 startingPage "483" @default.
• W2048600925 abstract "p97/valosin‐containing protein (VCP) is a member of the AAA family proteins, which plays various important roles in cells by using its ATPase activity. But mechanism of regulating its ATPase activity is mostly unknown. We report here that VCP is highly modified throughout the protein via acetylation and phosphorylation. In addition to six previously identified phosphorylation sites, we identified at least 14 serines, 14 threonines, 6 tyrosines and 22 lysines as potential modification sites. Interestingly, these sites included Lys 251 and Lys 524 , which are very critical for the ATP binding in Walker A motif of D1 and D2 domains, respectively. It is notable that 16 sites are in the N‐terminal region and 16 sites are clustered in D2α domain (from Pro 646 to Gly 765 ). Indeed, amino acid substitution of Lys 696 and Thr 761 profoundly affect VCP ATPase activities. From these results, we propose that D2α domain acts as a V CP A TPase R egulatory domain or “VAR domain”. VCP modifications including those in this VAR domain may endorse adaptive and multiple functions to VCP in different cell conditions such as in the cell cycle and with abnormal protein accumulation." @default.
• W2048600925 created "2016-06-24" @default.
• W2048600925 creator A5003795525 @default.
• W2048600925 creator A5007625745 @default.
• W2048600925 creator A5030158661 @default.
• W2048600925 creator A5033457571 @default.
• W2048600925 creator A5046029949 @default.
• W2048600925 creator A5055094058 @default.
• W2048600925 creator A5056924546 @default.
• W2048600925 creator A5058943390 @default.
• W2048600925 creator A5062225778 @default.
• W2048600925 creator A5069531433 @default.
• W2048600925 creator A5090193449 @default.
• W2048600925 date "2009-03-25" @default.
• W2048600925 modified "2023-10-06" @default.
• W2048600925 title "p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation" @default.
• W2048600925 cites W1495293344 @default.
• W2048600925 cites W1504764921 @default.
• W2048600925 cites W1528145391 @default.
• W2048600925 cites W162350361 @default.
• W2048600925 cites W1964347491 @default.
• W2048600925 cites W1964736714 @default.
• W2048600925 cites W1972918350 @default.
• W2048600925 cites W1974031565 @default.
• W2048600925 cites W1978922366 @default.
• W2048600925 cites W1979832500 @default.
• W2048600925 cites W1997202601 @default.
• W2048600925 cites W1999975922 @default.
• W2048600925 cites W2003079343 @default.
• W2048600925 cites W2011269026 @default.
• W2048600925 cites W2014609759 @default.
• W2048600925 cites W2018753611 @default.
• W2048600925 cites W2026465178 @default.
• W2048600925 cites W2033088972 @default.
• W2048600925 cites W2040551057 @default.
• W2048600925 cites W2048666997 @default.
• W2048600925 cites W2050743143 @default.
• W2048600925 cites W2052842467 @default.
• W2048600925 cites W2056607803 @default.
• W2048600925 cites W2064136366 @default.
• W2048600925 cites W2064959533 @default.
• W2048600925 cites W2067445670 @default.
• W2048600925 cites W2069553229 @default.
• W2048600925 cites W2073012734 @default.
• W2048600925 cites W2073476321 @default.
• W2048600925 cites W2078454026 @default.
• W2048600925 cites W2091787667 @default.
• W2048600925 cites W2100599614 @default.
• W2048600925 cites W2121296685 @default.
• W2048600925 cites W2125568224 @default.
• W2048600925 cites W2128761802 @default.
• W2048600925 cites W2146181664 @default.
• W2048600925 cites W2146885208 @default.
• W2048600925 cites W2146969978 @default.
• W2048600925 cites W2148495272 @default.
• W2048600925 cites W2162194331 @default.
• W2048600925 cites W2166032633 @default.
• W2048600925 doi "https://doi.org/10.1111/j.1365-2443.2009.01286.x" @default.
• W2048600925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19335618" @default.
• W2048600925 hasPublicationYear "2009" @default.
• W2048600925 type Work @default.
• W2048600925 sameAs 2048600925 @default.
• W2048600925 citedByCount "43" @default.
• W2048600925 countsByYear W20486009252012 @default.
• W2048600925 countsByYear W20486009252013 @default.
• W2048600925 countsByYear W20486009252014 @default.
• W2048600925 countsByYear W20486009252015 @default.
• W2048600925 countsByYear W20486009252016 @default.
• W2048600925 countsByYear W20486009252017 @default.
• W2048600925 countsByYear W20486009252018 @default.
• W2048600925 countsByYear W20486009252019 @default.
• W2048600925 countsByYear W20486009252020 @default.
• W2048600925 countsByYear W20486009252021 @default.
• W2048600925 countsByYear W20486009252022 @default.
• W2048600925 crossrefType "journal-article" @default.
• W2048600925 hasAuthorship W2048600925A5003795525 @default.
• W2048600925 hasAuthorship W2048600925A5007625745 @default.
• W2048600925 hasAuthorship W2048600925A5030158661 @default.
• W2048600925 hasAuthorship W2048600925A5033457571 @default.
• W2048600925 hasAuthorship W2048600925A5046029949 @default.
• W2048600925 hasAuthorship W2048600925A5055094058 @default.
• W2048600925 hasAuthorship W2048600925A5056924546 @default.
• W2048600925 hasAuthorship W2048600925A5058943390 @default.
• W2048600925 hasAuthorship W2048600925A5062225778 @default.
• W2048600925 hasAuthorship W2048600925A5069531433 @default.
• W2048600925 hasAuthorship W2048600925A5090193449 @default.
• W2048600925 hasBestOaLocation W20486009251 @default.
• W2048600925 hasConcept C101635128 @default.
• W2048600925 hasConcept C104317684 @default.
• W2048600925 hasConcept C119157956 @default.
• W2048600925 hasConcept C11960822 @default.
• W2048600925 hasConcept C144292202 @default.
• W2048600925 hasConcept C181199279 @default.
• W2048600925 hasConcept C23265538 @default.
• W2048600925 hasConcept C515207424 @default.
• W2048600925 hasConcept C55493867 @default.
• W2048600925 hasConcept C57711820 @default.
• W2048600925 hasConcept C86803240 @default.

• next