FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048607341> ?p ?o ?g. }

• W2048607341 abstract "Isothiocyanates (ITCs) from biodegradation of glucosinolates comprise a group of electrophiles associated with growth-inhibitory effects in plant- and mammalian cells. The underlying modes of action of this feature are not fully understood. Clarifying this has involved mammalian cancer cells due to ITCs' chemopreventive potential. The binding of ITCs to tubulins has been reported as a mechanism by which ITCs induce cell cycle arrest and apoptosis. In the present study we demonstrate that ITCs disrupt microtubules in Arabidopsis thaliana contributing to the observed inhibited growth phenotype. We also confirmed this in rat bladder cancer cells (AY-27) suggesting that cells from plant and animals share mechanisms by which ITCs affect growth. Exposure of A. thaliana to vapor-phase of allyl ITC (AITC) inhibited growth and induced a concurrent bleaching of leaves in a dose-dependent manner. Transcriptional analysis was used to show an upregulation of heat shock-genes upon AITC-treatment. Transgenic A. thaliana expressing GFP-marked α-tubulin was employed to show a time- and dose-dependent disintegration of microtubules by AITC. Treatment of AY-27 with ITCs resulted in a time- and dose-dependent decrease of cell proliferation and G2/M-arrest. AY-27 transiently transfected to express GFP-tagged α-tubulin were treated with ITCs resulting in a loss of microtubular filaments and the subsequent formation of apoptotic bodies. In conclusion, our data demonstrate an ITC-induced mechanism leading to growth inhibition in A. thaliana and rat bladder cancer cells, and expose clues to the mechanisms underlying the physiological role of glucosinolates in vivo." @default.
• W2048607341 created "2016-06-24" @default.
• W2048607341 creator A5049922665 @default.
• W2048607341 creator A5049988365 @default.
• W2048607341 creator A5052199121 @default.
• W2048607341 creator A5073449909 @default.
• W2048607341 date "2015-01-22" @default.
• W2048607341 modified "2023-09-26" @default.
• W2048607341 title "Disintegration of microtubules in Arabidopsis thaliana and bladder cancer cells by isothiocyanates" @default.
• W2048607341 cites W1533433098 @default.
• W2048607341 cites W1549049206 @default.
• W2048607341 cites W1555620850 @default.
• W2048607341 cites W1570238520 @default.
• W2048607341 cites W1964929981 @default.
• W2048607341 cites W1967077010 @default.
• W2048607341 cites W1970856028 @default.
• W2048607341 cites W1971056348 @default.
• W2048607341 cites W1973251558 @default.
• W2048607341 cites W1976406882 @default.
• W2048607341 cites W1984254481 @default.
• W2048607341 cites W1985219828 @default.
• W2048607341 cites W1996038316 @default.
• W2048607341 cites W2000327838 @default.
• W2048607341 cites W2005009329 @default.
• W2048607341 cites W2027353607 @default.
• W2048607341 cites W2035986050 @default.
• W2048607341 cites W2042322942 @default.
• W2048607341 cites W2044085158 @default.
• W2048607341 cites W2062363164 @default.
• W2048607341 cites W2064774881 @default.
• W2048607341 cites W2066179074 @default.
• W2048607341 cites W2068548171 @default.
• W2048607341 cites W2083178847 @default.
• W2048607341 cites W2089994609 @default.
• W2048607341 cites W2097269034 @default.
• W2048607341 cites W2099190519 @default.
• W2048607341 cites W2099299146 @default.
• W2048607341 cites W2106912497 @default.
• W2048607341 cites W2111491199 @default.
• W2048607341 cites W2111816936 @default.
• W2048607341 cites W2112058856 @default.
• W2048607341 cites W2119999468 @default.
• W2048607341 cites W2121314041 @default.
• W2048607341 cites W2123288502 @default.
• W2048607341 cites W2125559266 @default.
• W2048607341 cites W2138498649 @default.
• W2048607341 cites W2140794450 @default.
• W2048607341 cites W2147651641 @default.
• W2048607341 cites W2152916386 @default.
• W2048607341 cites W2153840778 @default.
• W2048607341 cites W2156204590 @default.
• W2048607341 cites W2156484726 @default.
• W2048607341 cites W2166888255 @default.
• W2048607341 cites W2169104458 @default.
• W2048607341 cites W2169919880 @default.
• W2048607341 cites W2178683691 @default.
• W2048607341 cites W2313524423 @default.
• W2048607341 cites W2475483490 @default.
• W2048607341 cites W2522006754 @default.
• W2048607341 cites W2012251823 @default.
• W2048607341 doi "https://doi.org/10.3389/fpls.2015.00006" @default.
• W2048607341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4303138" @default.
• W2048607341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25657654" @default.
• W2048607341 hasPublicationYear "2015" @default.
• W2048607341 type Work @default.
• W2048607341 sameAs 2048607341 @default.
• W2048607341 citedByCount "13" @default.
• W2048607341 countsByYear W20486073412015 @default.
• W2048607341 countsByYear W20486073412016 @default.
• W2048607341 countsByYear W20486073412017 @default.
• W2048607341 countsByYear W20486073412020 @default.
• W2048607341 countsByYear W20486073412021 @default.
• W2048607341 countsByYear W20486073412022 @default.
• W2048607341 countsByYear W20486073412023 @default.
• W2048607341 crossrefType "journal-article" @default.
• W2048607341 hasAuthorship W2048607341A5049922665 @default.
• W2048607341 hasAuthorship W2048607341A5049988365 @default.
• W2048607341 hasAuthorship W2048607341A5052199121 @default.
• W2048607341 hasAuthorship W2048607341A5073449909 @default.
• W2048607341 hasBestOaLocation W20486073411 @default.
• W2048607341 hasConcept C104317684 @default.
• W2048607341 hasConcept C121608353 @default.
• W2048607341 hasConcept C127561419 @default.
• W2048607341 hasConcept C143065580 @default.
• W2048607341 hasConcept C185592680 @default.
• W2048607341 hasConcept C190283241 @default.
• W2048607341 hasConcept C20418707 @default.
• W2048607341 hasConcept C2775988993 @default.
• W2048607341 hasConcept C54355233 @default.
• W2048607341 hasConcept C55493867 @default.
• W2048607341 hasConcept C86803240 @default.
• W2048607341 hasConcept C95444343 @default.
• W2048607341 hasConcept C96232424 @default.
• W2048607341 hasConceptScore W2048607341C104317684 @default.
• W2048607341 hasConceptScore W2048607341C121608353 @default.
• W2048607341 hasConceptScore W2048607341C127561419 @default.
• W2048607341 hasConceptScore W2048607341C143065580 @default.
• W2048607341 hasConceptScore W2048607341C185592680 @default.
• W2048607341 hasConceptScore W2048607341C190283241 @default.
• W2048607341 hasConceptScore W2048607341C20418707 @default.

• next