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- W2048608770 endingPage "1892" @default.
- W2048608770 startingPage "1885" @default.
- W2048608770 abstract "The intracellular routes of sphingolipid trafficking are related to the compartmentalized nature of sphingolipid metabolism, with synthesis beginning in the endoplasmic reticulum, continuing in the Golgi apparatus, and degradation occurring mainly in lysosomes. Whereas bulk sphingolipid transport between subcellular organelles occurs primarily via vesicle-mediated pathways, evidence is accumulating that sphingolipids are found in subcellular organelles that are not connected to each other by vesicular flow, implying additional trafficking routes. After discussing how sphingolipids are transported through the secretory pathway, I will review evidence for sphingolipid metabolism in organelles such as the mitochondria, and then discuss how this impacts upon our current understanding of the regulation of intracellular sphingolipid transport." @default.
- W2048608770 created "2016-06-24" @default.
- W2048608770 creator A5021535678 @default.
- W2048608770 date "2006-12-01" @default.
- W2048608770 modified "2023-09-25" @default.
- W2048608770 title "Intracellular trafficking of sphingolipids: Relationship to biosynthesis" @default.
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