FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048610900> ?p ?o ?g. }

• W2048610900 endingPage "25" @default.
• W2048610900 startingPage "21" @default.
• W2048610900 abstract "Intracellular deficiency of S-adenosylmethionine (AdoMet) and elevated serum concentrations of tumour necrosis factor α (TNF) are hallmarks of toxin-induced liver injury. In these models, the administration of either exogenous AdoMet or antibody/soluble receptor for TNF attenuates the injury. We have demonstrated previously that the administration of exogenous AdoMet to AdoMet-deficient rats attenuated lipopolysaccharide (LPS)-induced liver injury and serum TNF concentrations. Here we report that AdoMet lowered the amount of TNF secreted by LPS-stimulated murine macrophage cells (RAW 264.7) in a dose-dependent manner. The inhibition of TNF release was correlated with changes in the steady-state TNF mRNA concentrations. Changes in TNF mRNA were not due to its altered stability and might have been due to an attenuation of the transcription rate of the TNF gene. The inhibition of TNF release in RAW cells was not mediated by GSH because treatment with AdoMet did not increase intracellular GSH. In addition, N-acetylcysteine, whereas it did increase GSH concentration, had no effect on LPS-stimulated TNF release in these cells. Exogenous AdoMet also attenuated LPS-induced serum TNF levels in normal rats sensitized with lead. Thus AdoMet administration might exert its hepatoprotective effects at least in part by its inhibitory effect on expression of the gene for TNF." @default.
• W2048610900 created "2016-06-24" @default.
• W2048610900 creator A5031759042 @default.
• W2048610900 creator A5074581426 @default.
• W2048610900 creator A5082803074 @default.
• W2048610900 date "1999-08-10" @default.
• W2048610900 modified "2023-10-01" @default.
• W2048610900 title "<i>S</i>-Adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor α" @default.
• W2048610900 cites W1541927927 @default.
• W2048610900 cites W1670928643 @default.
• W2048610900 cites W1676709674 @default.
• W2048610900 cites W188360449 @default.
• W2048610900 cites W1980071084 @default.
• W2048610900 cites W1984006139 @default.
• W2048610900 cites W1984599257 @default.
• W2048610900 cites W1998868640 @default.
• W2048610900 cites W1999246265 @default.
• W2048610900 cites W2007437940 @default.
• W2048610900 cites W2040339940 @default.
• W2048610900 cites W2043329777 @default.
• W2048610900 cites W2043698453 @default.
• W2048610900 cites W2054511859 @default.
• W2048610900 cites W2054534199 @default.
• W2048610900 cites W2062178392 @default.
• W2048610900 cites W2063137402 @default.
• W2048610900 cites W2074291228 @default.
• W2048610900 cites W2077251398 @default.
• W2048610900 cites W2080187994 @default.
• W2048610900 cites W2085077927 @default.
• W2048610900 cites W2085122621 @default.
• W2048610900 cites W2085718426 @default.
• W2048610900 cites W2098295586 @default.
• W2048610900 cites W2146681915 @default.
• W2048610900 cites W2149623959 @default.
• W2048610900 cites W2151825728 @default.
• W2048610900 cites W2164672978 @default.
• W2048610900 cites W2167611648 @default.
• W2048610900 cites W2301587017 @default.
• W2048610900 cites W2333094115 @default.
• W2048610900 cites W2397860265 @default.
• W2048610900 cites W2404206528 @default.
• W2048610900 cites W4246904413 @default.
• W2048610900 doi "https://doi.org/10.1042/bj3420021" @default.
• W2048610900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1220431" @default.
• W2048610900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10432295" @default.
• W2048610900 hasPublicationYear "1999" @default.
• W2048610900 type Work @default.
• W2048610900 sameAs 2048610900 @default.
• W2048610900 citedByCount "88" @default.
• W2048610900 countsByYear W20486109002012 @default.
• W2048610900 countsByYear W20486109002013 @default.
• W2048610900 countsByYear W20486109002014 @default.
• W2048610900 countsByYear W20486109002015 @default.
• W2048610900 countsByYear W20486109002016 @default.
• W2048610900 countsByYear W20486109002017 @default.
• W2048610900 countsByYear W20486109002018 @default.
• W2048610900 countsByYear W20486109002019 @default.
• W2048610900 countsByYear W20486109002020 @default.
• W2048610900 countsByYear W20486109002021 @default.
• W2048610900 countsByYear W20486109002022 @default.
• W2048610900 countsByYear W20486109002023 @default.
• W2048610900 crossrefType "journal-article" @default.
• W2048610900 hasAuthorship W2048610900A5031759042 @default.
• W2048610900 hasAuthorship W2048610900A5074581426 @default.
• W2048610900 hasAuthorship W2048610900A5082803074 @default.
• W2048610900 hasBestOaLocation W20486109002 @default.
• W2048610900 hasConcept C104317684 @default.
• W2048610900 hasConcept C126322002 @default.
• W2048610900 hasConcept C134018914 @default.
• W2048610900 hasConcept C150194340 @default.
• W2048610900 hasConcept C153911025 @default.
• W2048610900 hasConcept C17991360 @default.
• W2048610900 hasConcept C181199279 @default.
• W2048610900 hasConcept C185592680 @default.
• W2048610900 hasConcept C2778754761 @default.
• W2048610900 hasConcept C538909803 @default.
• W2048610900 hasConcept C55493867 @default.
• W2048610900 hasConcept C71924100 @default.
• W2048610900 hasConcept C79879829 @default.
• W2048610900 hasConcept C86803240 @default.
• W2048610900 hasConcept C98274493 @default.
• W2048610900 hasConceptScore W2048610900C104317684 @default.
• W2048610900 hasConceptScore W2048610900C126322002 @default.
• W2048610900 hasConceptScore W2048610900C134018914 @default.
• W2048610900 hasConceptScore W2048610900C150194340 @default.
• W2048610900 hasConceptScore W2048610900C153911025 @default.
• W2048610900 hasConceptScore W2048610900C17991360 @default.
• W2048610900 hasConceptScore W2048610900C181199279 @default.
• W2048610900 hasConceptScore W2048610900C185592680 @default.
• W2048610900 hasConceptScore W2048610900C2778754761 @default.
• W2048610900 hasConceptScore W2048610900C538909803 @default.
• W2048610900 hasConceptScore W2048610900C55493867 @default.
• W2048610900 hasConceptScore W2048610900C71924100 @default.
• W2048610900 hasConceptScore W2048610900C79879829 @default.
• W2048610900 hasConceptScore W2048610900C86803240 @default.
• W2048610900 hasConceptScore W2048610900C98274493 @default.
• W2048610900 hasIssue "1" @default.
• W2048610900 hasLocation W20486109001 @default.

• next