FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048623190> ?p ?o ?g. }

• W2048623190 endingPage "1245" @default.
• W2048623190 startingPage "1234" @default.
• W2048623190 abstract "Increased recognition of the advantages of genetic animal models has led to heightened interest in their use and development. A replicated bidirectional selective breeding project has produced lines of mice that differ in their locomotor responses to 2.0 g/kg ethanol. FAST-1 and FAST-2 mice are highly stimulated by ethanol (EtOH), whereas SLOW-1 and SLOW-2 mice are either not affected or respond with locomotor depression. Current heritability estimates indicate that approximately 6-8% of the response variance in the FAST lines and 2-10% of the response variance in the SLOW lines is of additive genetic origin. Little systematic response to selection has occurred in recent generations, which implies that the limits of selection have been reached. Analysis of saline activity over 35 generations of selection indicates that baseline activities have not changed during the course of selection in three of the lines, whereas baseline activity of FAST-1 mice has increased slightly. In EtOH dose-response studies (0.5-3.0 g/kg), FAST mice had biphasic dose-response curves, whereas the locomotor activity of SLOW mice was either unaffected or depressed by all doses of EtOH. In addition, FAST mice spent more time in motion, traveled farther per movement, traversed greater distances in the center of the test chamber, and ambulated more quickly than SLOW mice when given EtOH. FAST and SLOW mice differed in EtOH clearance rates; however, the differences were slight relative to the large difference in locomotor response. We encourage the use of FAST and SLOW mice to investigate neurophysiological factors underlying sensitivity to the behavioral effects of EtOH, with a view to further testing of the postulated homology between locomotor stimulant effects and addiction potential of drugs of abuse." @default.
• W2048623190 created "2016-06-24" @default.
• W2048623190 creator A5008609077 @default.
• W2048623190 creator A5038492593 @default.
• W2048623190 creator A5041232682 @default.
• W2048623190 creator A5044661102 @default.
• W2048623190 date "1995-10-01" @default.
• W2048623190 modified "2023-10-15" @default.
• W2048623190 title "Bidirectional Selective Breeding for Ethanol Effects on Locomotor Activity: Characterization of FAST and SLOW Mice Through Selection Generation 35" @default.
• W2048623190 cites W1970767988 @default.
• W2048623190 cites W1974197167 @default.
• W2048623190 cites W1975132784 @default.
• W2048623190 cites W1989228691 @default.
• W2048623190 cites W1994267968 @default.
• W2048623190 cites W1999786800 @default.
• W2048623190 cites W2000912211 @default.
• W2048623190 cites W2019242349 @default.
• W2048623190 cites W2038649822 @default.
• W2048623190 cites W2039266244 @default.
• W2048623190 cites W2040827688 @default.
• W2048623190 cites W2045075681 @default.
• W2048623190 cites W2063188779 @default.
• W2048623190 cites W2065337015 @default.
• W2048623190 cites W2079214445 @default.
• W2048623190 cites W2081279872 @default.
• W2048623190 cites W2086445060 @default.
• W2048623190 cites W2091317536 @default.
• W2048623190 cites W2411622517 @default.
• W2048623190 cites W4255451542 @default.
• W2048623190 cites W99993437 @default.
• W2048623190 doi "https://doi.org/10.1111/j.1530-0277.1995.tb01606.x" @default.
• W2048623190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8561296" @default.
• W2048623190 hasPublicationYear "1995" @default.
• W2048623190 type Work @default.
• W2048623190 sameAs 2048623190 @default.
• W2048623190 citedByCount "60" @default.
• W2048623190 countsByYear W20486231902012 @default.
• W2048623190 countsByYear W20486231902013 @default.
• W2048623190 countsByYear W20486231902014 @default.
• W2048623190 countsByYear W20486231902015 @default.
• W2048623190 countsByYear W20486231902017 @default.
• W2048623190 countsByYear W20486231902019 @default.
• W2048623190 countsByYear W20486231902021 @default.
• W2048623190 crossrefType "journal-article" @default.
• W2048623190 hasAuthorship W2048623190A5008609077 @default.
• W2048623190 hasAuthorship W2048623190A5038492593 @default.
• W2048623190 hasAuthorship W2048623190A5041232682 @default.
• W2048623190 hasAuthorship W2048623190A5044661102 @default.
• W2048623190 hasConcept C12558332 @default.
• W2048623190 hasConcept C126322002 @default.
• W2048623190 hasConcept C134018914 @default.
• W2048623190 hasConcept C140793950 @default.
• W2048623190 hasConcept C154945302 @default.
• W2048623190 hasConcept C161890455 @default.
• W2048623190 hasConcept C185592680 @default.
• W2048623190 hasConcept C202751555 @default.
• W2048623190 hasConcept C2777397205 @default.
• W2048623190 hasConcept C2778117688 @default.
• W2048623190 hasConcept C2780161600 @default.
• W2048623190 hasConcept C2993436365 @default.
• W2048623190 hasConcept C41008148 @default.
• W2048623190 hasConcept C42533223 @default.
• W2048623190 hasConcept C54355233 @default.
• W2048623190 hasConcept C55493867 @default.
• W2048623190 hasConcept C71924100 @default.
• W2048623190 hasConcept C81917197 @default.
• W2048623190 hasConcept C86803240 @default.
• W2048623190 hasConcept C99476002 @default.
• W2048623190 hasConceptScore W2048623190C12558332 @default.
• W2048623190 hasConceptScore W2048623190C126322002 @default.
• W2048623190 hasConceptScore W2048623190C134018914 @default.
• W2048623190 hasConceptScore W2048623190C140793950 @default.
• W2048623190 hasConceptScore W2048623190C154945302 @default.
• W2048623190 hasConceptScore W2048623190C161890455 @default.
• W2048623190 hasConceptScore W2048623190C185592680 @default.
• W2048623190 hasConceptScore W2048623190C202751555 @default.
• W2048623190 hasConceptScore W2048623190C2777397205 @default.
• W2048623190 hasConceptScore W2048623190C2778117688 @default.
• W2048623190 hasConceptScore W2048623190C2780161600 @default.
• W2048623190 hasConceptScore W2048623190C2993436365 @default.
• W2048623190 hasConceptScore W2048623190C41008148 @default.
• W2048623190 hasConceptScore W2048623190C42533223 @default.
• W2048623190 hasConceptScore W2048623190C54355233 @default.
• W2048623190 hasConceptScore W2048623190C55493867 @default.
• W2048623190 hasConceptScore W2048623190C71924100 @default.
• W2048623190 hasConceptScore W2048623190C81917197 @default.
• W2048623190 hasConceptScore W2048623190C86803240 @default.
• W2048623190 hasConceptScore W2048623190C99476002 @default.
• W2048623190 hasIssue "5" @default.
• W2048623190 hasLocation W20486231901 @default.
• W2048623190 hasLocation W20486231902 @default.
• W2048623190 hasOpenAccess W2048623190 @default.
• W2048623190 hasPrimaryLocation W20486231901 @default.
• W2048623190 hasRelatedWork W1976163447 @default.
• W2048623190 hasRelatedWork W2043912886 @default.
• W2048623190 hasRelatedWork W2110808585 @default.
• W2048623190 hasRelatedWork W2137301703 @default.
• W2048623190 hasRelatedWork W2258846206 @default.

• next