FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048627992> ?p ?o ?g. }

• W2048627992 endingPage "e34088" @default.
• W2048627992 startingPage "e34088" @default.
• W2048627992 abstract "Bone morphogenetic proteins (BMPs) are considered important regulators of neural development. However, results mainly from a wide set of in vitro gain-of-function experiments are conflicting since these show that BMPs can act either as inhibitors or promoters of neurogenesis. Here, we report a specific and non-redundant role for BMP7 in cortical neurogenesis in vivo using knockout mice. Bmp7 is produced in regions adjacent to the developing cortex; the hem, meninges, and choroid plexus, and can be detected in the cerebrospinal fluid. Bmp7 deletion results in reduced cortical thickening, impaired neurogenesis, and loss of radial glia attachment to the meninges. Subsequent in vitro analyses of E14.5 cortical cells revealed that lack of Bmp7 affects neural progenitor cells, evidenced by their reduced proliferation, survival and self-renewal capacity. Addition of BMP7 was able to rescue these proliferation and survival defects. In addition, at the developmental stage E14.5 Bmp7 was also required to maintain Ngn2 expression in the subventricular zone. These data demonstrate a novel role for Bmp7 in the embryonic mouse cortex: Bmp7 nurtures radial glia cells and regulates fundamental properties of neural progenitor cells that subsequently affect Ngn2-dependent neurogenesis." @default.
• W2048627992 created "2016-06-24" @default.
• W2048627992 creator A5006000290 @default.
• W2048627992 creator A5007934923 @default.
• W2048627992 creator A5009448621 @default.
• W2048627992 creator A5014999240 @default.
• W2048627992 creator A5028006830 @default.
• W2048627992 creator A5028564293 @default.
• W2048627992 creator A5029424457 @default.
• W2048627992 creator A5029543737 @default.
• W2048627992 creator A5070369234 @default.
• W2048627992 date "2012-03-26" @default.
• W2048627992 modified "2023-10-02" @default.
• W2048627992 title "Bmp7 Regulates the Survival, Proliferation, and Neurogenic Properties of Neural Progenitor Cells during Corticogenesis in the Mouse" @default.
• W2048627992 cites W1483863796 @default.
• W2048627992 cites W1639109957 @default.
• W2048627992 cites W1851488602 @default.
• W2048627992 cites W1963900159 @default.
• W2048627992 cites W1967611229 @default.
• W2048627992 cites W1977060481 @default.
• W2048627992 cites W1979890518 @default.
• W2048627992 cites W1988115577 @default.
• W2048627992 cites W1988976106 @default.
• W2048627992 cites W1990935914 @default.
• W2048627992 cites W1995892646 @default.
• W2048627992 cites W1996194752 @default.
• W2048627992 cites W1996567361 @default.
• W2048627992 cites W2000183175 @default.
• W2048627992 cites W2005891911 @default.
• W2048627992 cites W2008044940 @default.
• W2048627992 cites W2018503593 @default.
• W2048627992 cites W2022628636 @default.
• W2048627992 cites W2023128786 @default.
• W2048627992 cites W2031482377 @default.
• W2048627992 cites W2045154999 @default.
• W2048627992 cites W2059532441 @default.
• W2048627992 cites W2067011924 @default.
• W2048627992 cites W2069479018 @default.
• W2048627992 cites W2076220903 @default.
• W2048627992 cites W2079306212 @default.
• W2048627992 cites W2079881283 @default.
• W2048627992 cites W2080163838 @default.
• W2048627992 cites W2082465202 @default.
• W2048627992 cites W2083131697 @default.
• W2048627992 cites W2084921473 @default.
• W2048627992 cites W2087717851 @default.
• W2048627992 cites W2088654564 @default.
• W2048627992 cites W2093271566 @default.
• W2048627992 cites W2095153889 @default.
• W2048627992 cites W2100855116 @default.
• W2048627992 cites W2102262576 @default.
• W2048627992 cites W2104557195 @default.
• W2048627992 cites W2114245705 @default.
• W2048627992 cites W2124109473 @default.
• W2048627992 cites W2124142272 @default.
• W2048627992 cites W2124415162 @default.
• W2048627992 cites W2127220436 @default.
• W2048627992 cites W2129016496 @default.
• W2048627992 cites W2133193835 @default.
• W2048627992 cites W2139470337 @default.
• W2048627992 cites W2139816400 @default.
• W2048627992 cites W2140840483 @default.
• W2048627992 cites W2142820864 @default.
• W2048627992 cites W2155166279 @default.
• W2048627992 cites W2170044387 @default.
• W2048627992 cites W4236562847 @default.
• W2048627992 cites W4244095134 @default.
• W2048627992 doi "https://doi.org/10.1371/journal.pone.0034088" @default.
• W2048627992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3312908" @default.
• W2048627992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22461901" @default.
• W2048627992 hasPublicationYear "2012" @default.
• W2048627992 type Work @default.
• W2048627992 sameAs 2048627992 @default.
• W2048627992 citedByCount "76" @default.
• W2048627992 countsByYear W20486279922013 @default.
• W2048627992 countsByYear W20486279922014 @default.
• W2048627992 countsByYear W20486279922015 @default.
• W2048627992 countsByYear W20486279922016 @default.
• W2048627992 countsByYear W20486279922017 @default.
• W2048627992 countsByYear W20486279922018 @default.
• W2048627992 countsByYear W20486279922019 @default.
• W2048627992 countsByYear W20486279922020 @default.
• W2048627992 countsByYear W20486279922021 @default.
• W2048627992 countsByYear W20486279922022 @default.
• W2048627992 countsByYear W20486279922023 @default.
• W2048627992 crossrefType "journal-article" @default.
• W2048627992 hasAuthorship W2048627992A5006000290 @default.
• W2048627992 hasAuthorship W2048627992A5007934923 @default.
• W2048627992 hasAuthorship W2048627992A5009448621 @default.
• W2048627992 hasAuthorship W2048627992A5014999240 @default.
• W2048627992 hasAuthorship W2048627992A5028006830 @default.
• W2048627992 hasAuthorship W2048627992A5028564293 @default.
• W2048627992 hasAuthorship W2048627992A5029424457 @default.
• W2048627992 hasAuthorship W2048627992A5029543737 @default.
• W2048627992 hasAuthorship W2048627992A5070369234 @default.
• W2048627992 hasBestOaLocation W20486279921 @default.
• W2048627992 hasConcept C104317684 @default.
• W2048627992 hasConcept C108619961 @default.

• next