Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048630895> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2048630895 endingPage "1273" @default.
- W2048630895 startingPage "1267" @default.
- W2048630895 abstract "We first identified arfaptin as a protein that bound to GTP-ARFs (especially ARF1). However, a second group reported that POR1, a truncated form of arfaptin, bound to GTP-Rac1. Therefore, we examined the possibility that arfaptin 2/POR1 was a common downstream effector for both ARF1 and Rac1. In this study, we found that constitutively active Rac1 or GTP-Rac1 showed negligible or no binding to arfaptin 2/POR1 in a yeast two-hybrid assay or a GST pull-down assay. However, wild-type or dominant negative Rac1 or Rac1 liganded to GDP showed strong binding. In contrast, constitutively active ARFs1, 5, and 6 showed binding, whereas the wild-type and dominant negative forms did not. Furthermore, the GTP-liganded ARFs bound arfaptin 2, whereas the GDP-bound forms showed little or no binding. Based on these observations, we suggest that arfaptin 2/POR1 is a target protein for GTP-ARFs and for GDP-Rac1, and that it may be involved in interactions between the Rac and ARF signaling pathways." @default.
- W2048630895 created "2016-06-24" @default.
- W2048630895 creator A5063926336 @default.
- W2048630895 creator A5089123548 @default.
- W2048630895 date "2001-08-01" @default.
- W2048630895 modified "2023-10-14" @default.
- W2048630895 title "Differential Binding of Arfaptin 2/POR1 to ADP-Ribosylation Factors and Rac1" @default.
- W2048630895 cites W1520020505 @default.
- W2048630895 cites W1520241460 @default.
- W2048630895 cites W1655079079 @default.
- W2048630895 cites W1751582242 @default.
- W2048630895 cites W1973743273 @default.
- W2048630895 cites W1977186059 @default.
- W2048630895 cites W1982911692 @default.
- W2048630895 cites W2006236607 @default.
- W2048630895 cites W2008046589 @default.
- W2048630895 cites W2015650502 @default.
- W2048630895 cites W2040089786 @default.
- W2048630895 cites W2046158544 @default.
- W2048630895 cites W2060540033 @default.
- W2048630895 cites W2068881539 @default.
- W2048630895 cites W2069177549 @default.
- W2048630895 cites W2071946819 @default.
- W2048630895 cites W2074937633 @default.
- W2048630895 cites W2075887159 @default.
- W2048630895 cites W2092954353 @default.
- W2048630895 cites W2094950517 @default.
- W2048630895 cites W2099731590 @default.
- W2048630895 doi "https://doi.org/10.1006/bbrc.2001.5330" @default.
- W2048630895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11478794" @default.
- W2048630895 hasPublicationYear "2001" @default.
- W2048630895 type Work @default.
- W2048630895 sameAs 2048630895 @default.
- W2048630895 citedByCount "49" @default.
- W2048630895 countsByYear W20486308952012 @default.
- W2048630895 countsByYear W20486308952013 @default.
- W2048630895 countsByYear W20486308952014 @default.
- W2048630895 countsByYear W20486308952015 @default.
- W2048630895 countsByYear W20486308952016 @default.
- W2048630895 countsByYear W20486308952017 @default.
- W2048630895 countsByYear W20486308952019 @default.
- W2048630895 countsByYear W20486308952020 @default.
- W2048630895 countsByYear W20486308952022 @default.
- W2048630895 crossrefType "journal-article" @default.
- W2048630895 hasAuthorship W2048630895A5063926336 @default.
- W2048630895 hasAuthorship W2048630895A5089123548 @default.
- W2048630895 hasConcept C118716 @default.
- W2048630895 hasConcept C181199279 @default.
- W2048630895 hasConcept C185592680 @default.
- W2048630895 hasConcept C207332259 @default.
- W2048630895 hasConcept C2779717556 @default.
- W2048630895 hasConcept C51785407 @default.
- W2048630895 hasConcept C55493867 @default.
- W2048630895 hasConcept C62478195 @default.
- W2048630895 hasConcept C86803240 @default.
- W2048630895 hasConcept C95444343 @default.
- W2048630895 hasConceptScore W2048630895C118716 @default.
- W2048630895 hasConceptScore W2048630895C181199279 @default.
- W2048630895 hasConceptScore W2048630895C185592680 @default.
- W2048630895 hasConceptScore W2048630895C207332259 @default.
- W2048630895 hasConceptScore W2048630895C2779717556 @default.
- W2048630895 hasConceptScore W2048630895C51785407 @default.
- W2048630895 hasConceptScore W2048630895C55493867 @default.
- W2048630895 hasConceptScore W2048630895C62478195 @default.
- W2048630895 hasConceptScore W2048630895C86803240 @default.
- W2048630895 hasConceptScore W2048630895C95444343 @default.
- W2048630895 hasIssue "5" @default.
- W2048630895 hasLocation W20486308951 @default.
- W2048630895 hasLocation W20486308952 @default.
- W2048630895 hasOpenAccess W2048630895 @default.
- W2048630895 hasPrimaryLocation W20486308951 @default.
- W2048630895 hasRelatedWork W1540219323 @default.
- W2048630895 hasRelatedWork W1570552209 @default.
- W2048630895 hasRelatedWork W1976401619 @default.
- W2048630895 hasRelatedWork W2000236507 @default.
- W2048630895 hasRelatedWork W2008470784 @default.
- W2048630895 hasRelatedWork W2072932710 @default.
- W2048630895 hasRelatedWork W2331905247 @default.
- W2048630895 hasRelatedWork W2769412055 @default.
- W2048630895 hasRelatedWork W4383058836 @default.
- W2048630895 hasRelatedWork W2186443916 @default.
- W2048630895 hasVolume "285" @default.
- W2048630895 isParatext "false" @default.
- W2048630895 isRetracted "false" @default.
- W2048630895 magId "2048630895" @default.
- W2048630895 workType "article" @default.