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• W2048634508 endingPage "1371" @default.
• W2048634508 startingPage "1362" @default.
• W2048634508 abstract "BACKGROUND C/EBPβ is a transcription factor regulating key biological processes including cellular growth and differentiation and its increased expression correlates with tumor invasiveness. Recently, the increased expression of C/EBPβ was reported in proliferative inflammatory atrophy of the prostate, associating with increased COX-2 expression and androgen receptor (AR) downregulation. METHODS C/EBPβ expression was determined in DU-145, PC-3 and LNCaP cells by immunoblotting. Transient transfection of C/EBPβ expression vectors was performed to investigate translational regulation of its isoform expression. Reporter gene analysis was performed to investigate transcriptional activity of C/EBPβ on metastatic gene expression. RESULTS We determined that transcriptionally active, full-length C/EBPβ isoforms were dominantly expressed in hormone-independent DU-145 and PC-3 cells, while transcription-repressing truncated isoform was dominant in hormone-dependent LNCaP cells. Our results further showed lack of full-length isoform expression from the transiently transfected C/EBPβ expression vector in LNCaP cells compared to that in PC-3 cells transfected with the same vector, while the expression of truncated isoform was comparable in both cell lines. Interestingly, however, the most upstream initiation site A null mutation restored translation of full-length isoform in LNCaP cells. These results suggest that full-length C/EBPβ isoform expression in LNCaP cells may be suppressed at the upstream initiation sites, likely at site A. Most importantly, C/EBPβ overexpression significantly upregulated promoter activities of IL-8, COX-2, and anti-apoptotic Bfl-1 genes. CONCLUSIONS Our study demonstrates that C/EBPβ is an important transcription factor upregulating metastatic gene expression and that its isoform expression is differentially regulated at the translational level in prostate cancer cells. Prostate 68:1362–1371, 2008. © 2008 Wiley-Liss, Inc." @default.
• W2048634508 created "2016-06-24" @default.
• W2048634508 creator A5006615187 @default.
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• W2048634508 date "2008-09-01" @default.
• W2048634508 modified "2023-09-25" @default.
• W2048634508 title "Translationally regulated C/EBPβ isoform expression upregulates metastatic genes in hormone-independent prostate cancer cells" @default.
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• W2048634508 doi "https://doi.org/10.1002/pros.20801" @default.
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