FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048648012> ?p ?o ?g. }

• W2048648012 endingPage "14" @default.
• W2048648012 startingPage "1" @default.
• W2048648012 abstract "The many biological activities of the hormone gastrin-releasing peptide (GRP), including stimulation of acid secretion and of tumour growth, are mediated by the gastrin-releasing peptide receptor (GRP-R). Here sequence comparisons are utilised to investigate the likely bioactive regions of the 125 amino acid GRP precursor and of GRP-R. Comparison of the sequences of the GRP precursor from 21 species revealed homology not only in the GRP region between amino acids 1 and 30, but also in C-terminal regions from amino acids 43 to 97. This observation is consistent with recent reports that peptides derived from the C-terminal region are biologically active. Comparison of the GRP-R sequence with the related receptors NMB-R and BRS-3 revealed that the family could be distinguished from other G-protein coupled receptors by the presence of the motif GVSVFTLTALS at the cytoplasmic end of transmembrane helix 3. Comparison of the sequences of the GRP-R from 21 species revealed that the most highly conserved regions occurred in transmembrane helices 2, 3, 5, 6 and 7, and in the third intracellular loop. These results will be important in guiding future structure–function studies of the GRP precursor and of GRP receptors." @default.
• W2048648012 created "2016-06-24" @default.
• W2048648012 creator A5056263381 @default.
• W2048648012 creator A5075669832 @default.
• W2048648012 creator A5089939339 @default.
• W2048648012 date "2007-10-01" @default.
• W2048648012 modified "2023-10-17" @default.
• W2048648012 title "Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: Biological implications" @default.
• W2048648012 cites W1522189913 @default.
• W2048648012 cites W1530797390 @default.
• W2048648012 cites W1537449868 @default.
• W2048648012 cites W1569320272 @default.
• W2048648012 cites W1966064939 @default.
• W2048648012 cites W1971463454 @default.
• W2048648012 cites W1972689154 @default.
• W2048648012 cites W1972769194 @default.
• W2048648012 cites W1974094437 @default.
• W2048648012 cites W1980452711 @default.
• W2048648012 cites W1981770260 @default.
• W2048648012 cites W1985116411 @default.
• W2048648012 cites W1986970519 @default.
• W2048648012 cites W1994672525 @default.
• W2048648012 cites W1996701246 @default.
• W2048648012 cites W2004529428 @default.
• W2048648012 cites W2005017658 @default.
• W2048648012 cites W2005688520 @default.
• W2048648012 cites W2007208508 @default.
• W2048648012 cites W2012603088 @default.
• W2048648012 cites W2018279434 @default.
• W2048648012 cites W2020257493 @default.
• W2048648012 cites W2021053040 @default.
• W2048648012 cites W2023063407 @default.
• W2048648012 cites W2023660643 @default.
• W2048648012 cites W2023951795 @default.
• W2048648012 cites W2030330371 @default.
• W2048648012 cites W2031956553 @default.
• W2048648012 cites W2032197321 @default.
• W2048648012 cites W2049782036 @default.
• W2048648012 cites W2052275957 @default.
• W2048648012 cites W2056241741 @default.
• W2048648012 cites W2059751684 @default.
• W2048648012 cites W2062098928 @default.
• W2048648012 cites W2063332267 @default.
• W2048648012 cites W2070345064 @default.
• W2048648012 cites W2072570259 @default.
• W2048648012 cites W2075952531 @default.
• W2048648012 cites W2078381333 @default.
• W2048648012 cites W2079835420 @default.
• W2048648012 cites W2082344712 @default.
• W2048648012 cites W2084712453 @default.
• W2048648012 cites W2087310960 @default.
• W2048648012 cites W2089488290 @default.
• W2048648012 cites W2114082871 @default.
• W2048648012 cites W2116409462 @default.
• W2048648012 cites W2134517304 @default.
• W2048648012 cites W2139037564 @default.
• W2048648012 cites W2139996880 @default.
• W2048648012 cites W2142331821 @default.
• W2048648012 cites W2149963584 @default.
• W2048648012 cites W2156103946 @default.
• W2048648012 cites W2167549601 @default.
• W2048648012 cites W2188357988 @default.
• W2048648012 cites W2227095215 @default.
• W2048648012 cites W4251381133 @default.
• W2048648012 cites W4255692947 @default.
• W2048648012 cites W4323284734 @default.
• W2048648012 doi "https://doi.org/10.1016/j.regpep.2007.02.007" @default.
• W2048648012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17395282" @default.
• W2048648012 hasPublicationYear "2007" @default.
• W2048648012 type Work @default.
• W2048648012 sameAs 2048648012 @default.
• W2048648012 citedByCount "20" @default.
• W2048648012 countsByYear W20486480122012 @default.
• W2048648012 countsByYear W20486480122013 @default.
• W2048648012 countsByYear W20486480122014 @default.
• W2048648012 countsByYear W20486480122015 @default.
• W2048648012 countsByYear W20486480122016 @default.
• W2048648012 countsByYear W20486480122018 @default.
• W2048648012 countsByYear W20486480122020 @default.
• W2048648012 crossrefType "journal-article" @default.
• W2048648012 hasAuthorship W2048648012A5056263381 @default.
• W2048648012 hasAuthorship W2048648012A5075669832 @default.
• W2048648012 hasAuthorship W2048648012A5089939339 @default.
• W2048648012 hasConcept C104317684 @default.
• W2048648012 hasConcept C116073593 @default.
• W2048648012 hasConcept C118303440 @default.
• W2048648012 hasConcept C118892022 @default.
• W2048648012 hasConcept C167625842 @default.
• W2048648012 hasConcept C170493617 @default.
• W2048648012 hasConcept C202751555 @default.
• W2048648012 hasConcept C24530287 @default.
• W2048648012 hasConcept C2776986829 @default.
• W2048648012 hasConcept C2776998989 @default.
• W2048648012 hasConcept C2778448772 @default.
• W2048648012 hasConcept C2779281246 @default.
• W2048648012 hasConcept C49039625 @default.
• W2048648012 hasConcept C515207424 @default.
• W2048648012 hasConcept C55493867 @default.

• next