FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048651409> ?p ?o ?g. }

• W2048651409 endingPage "388" @default.
• W2048651409 startingPage "385" @default.
• W2048651409 abstract "ALS is the most common motor neurone disorder in human adults. Scanty data on endocrine abnormalities have been reported. The aim of the present study was to investigate the GH-IGF-I axis in ALS patients.Twenty-two ALS patients (12 men, 10 women), mean age 61 years, and 25 normal age- and sex-matched subjects. No patient was under riluzole therapy.Patients and controls underwent a GHRH plus arginine test. IGF-I was determined at baseline. A complete evaluation of pituitary function was also performed.Mean (+/- SD) basal GH levels were significantly reduced compared with normal controls (0.2 +/- 0.3 vs 1.6 +/- 1.8 ng/ml, P < 0.01), as well as peak GH concentrations after GHRH + arginine administration (12.6 +/- 8.9 vs 39.9 +/- 18.7 ng/ml, P < 0.001). Six (27%) patients showed a normal GH response to stimulus; 7 (32%) patients displayed a moderate GH deficiency; in 9 (40%) patients GH response was markedly deficient. IGF-I levels were normal in the majority of patients (mean +/- SD: 143.6 +/- 63.8 ng/ml). No significant correlation was observed between peak GH concentrations and age, BMI, disease duration, severity or clinical form. A higher incidence of GH deficiency was observed in male compared to female patients (83%vs 60%), with a peak GH response in males significantly lower than in females (8.9 +/- 6.6 vs 17 +/- 9.6 ng/ml, P = 0.03). Eighteen patients repeated the test after 5 months and similar results were obtained.The present data indicate a reduction of GH secretion in ALS patients." @default.
• W2048651409 created "2016-06-24" @default.
• W2048651409 creator A5004603683 @default.
• W2048651409 creator A5035907011 @default.
• W2048651409 creator A5037524730 @default.
• W2048651409 creator A5044767795 @default.
• W2048651409 creator A5045676608 @default.
• W2048651409 creator A5049500070 @default.
• W2048651409 creator A5059525187 @default.
• W2048651409 creator A5062775036 @default.
• W2048651409 creator A5084714939 @default.
• W2048651409 date "2006-07-06" @default.
• W2048651409 modified "2023-10-15" @default.
• W2048651409 title "Growth hormone secretion is impaired in amyotrophic lateral sclerosis" @default.
• W2048651409 cites W1964607170 @default.
• W2048651409 cites W1967254674 @default.
• W2048651409 cites W1981224691 @default.
• W2048651409 cites W1986794946 @default.
• W2048651409 cites W1991177666 @default.
• W2048651409 cites W2010677584 @default.
• W2048651409 cites W2015253115 @default.
• W2048651409 cites W2018202764 @default.
• W2048651409 cites W2041381596 @default.
• W2048651409 cites W2041952809 @default.
• W2048651409 cites W2049639690 @default.
• W2048651409 cites W2072562340 @default.
• W2048651409 cites W2095241529 @default.
• W2048651409 cites W2100787857 @default.
• W2048651409 cites W2125896595 @default.
• W2048651409 cites W2140679517 @default.
• W2048651409 cites W2606513528 @default.
• W2048651409 cites W4229936541 @default.
• W2048651409 cites W4234159563 @default.
• W2048651409 cites W4245683607 @default.
• W2048651409 doi "https://doi.org/10.1111/j.1365-2265.2006.02609.x" @default.
• W2048651409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16918961" @default.
• W2048651409 hasPublicationYear "2006" @default.
• W2048651409 type Work @default.
• W2048651409 sameAs 2048651409 @default.
• W2048651409 citedByCount "32" @default.
• W2048651409 countsByYear W20486514092012 @default.
• W2048651409 countsByYear W20486514092013 @default.
• W2048651409 countsByYear W20486514092014 @default.
• W2048651409 countsByYear W20486514092015 @default.
• W2048651409 countsByYear W20486514092017 @default.
• W2048651409 countsByYear W20486514092019 @default.
• W2048651409 countsByYear W20486514092020 @default.
• W2048651409 countsByYear W20486514092021 @default.
• W2048651409 countsByYear W20486514092023 @default.
• W2048651409 crossrefType "journal-article" @default.
• W2048651409 hasAuthorship W2048651409A5004603683 @default.
• W2048651409 hasAuthorship W2048651409A5035907011 @default.
• W2048651409 hasAuthorship W2048651409A5037524730 @default.
• W2048651409 hasAuthorship W2048651409A5044767795 @default.
• W2048651409 hasAuthorship W2048651409A5045676608 @default.
• W2048651409 hasAuthorship W2048651409A5049500070 @default.
• W2048651409 hasAuthorship W2048651409A5059525187 @default.
• W2048651409 hasAuthorship W2048651409A5062775036 @default.
• W2048651409 hasAuthorship W2048651409A5084714939 @default.
• W2048651409 hasConcept C126322002 @default.
• W2048651409 hasConcept C134018914 @default.
• W2048651409 hasConcept C2778024521 @default.
• W2048651409 hasConcept C2779134260 @default.
• W2048651409 hasConcept C2779306644 @default.
• W2048651409 hasConcept C2779952775 @default.
• W2048651409 hasConcept C2780596555 @default.
• W2048651409 hasConcept C2984496839 @default.
• W2048651409 hasConcept C71315377 @default.
• W2048651409 hasConcept C71924100 @default.
• W2048651409 hasConceptScore W2048651409C126322002 @default.
• W2048651409 hasConceptScore W2048651409C134018914 @default.
• W2048651409 hasConceptScore W2048651409C2778024521 @default.
• W2048651409 hasConceptScore W2048651409C2779134260 @default.
• W2048651409 hasConceptScore W2048651409C2779306644 @default.
• W2048651409 hasConceptScore W2048651409C2779952775 @default.
• W2048651409 hasConceptScore W2048651409C2780596555 @default.
• W2048651409 hasConceptScore W2048651409C2984496839 @default.
• W2048651409 hasConceptScore W2048651409C71315377 @default.
• W2048651409 hasConceptScore W2048651409C71924100 @default.
• W2048651409 hasIssue "3" @default.
• W2048651409 hasLocation W20486514091 @default.
• W2048651409 hasLocation W20486514092 @default.
• W2048651409 hasOpenAccess W2048651409 @default.
• W2048651409 hasPrimaryLocation W20486514091 @default.
• W2048651409 hasRelatedWork W2035676088 @default.
• W2048651409 hasRelatedWork W2040792760 @default.
• W2048651409 hasRelatedWork W2078449871 @default.
• W2048651409 hasRelatedWork W2141888016 @default.
• W2048651409 hasRelatedWork W2766969746 @default.
• W2048651409 hasRelatedWork W2915937120 @default.
• W2048651409 hasRelatedWork W3092097633 @default.
• W2048651409 hasRelatedWork W4249303995 @default.
• W2048651409 hasRelatedWork W4312173183 @default.
• W2048651409 hasRelatedWork W49358886 @default.
• W2048651409 hasVolume "65" @default.
• W2048651409 isParatext "false" @default.
• W2048651409 isRetracted "false" @default.
• W2048651409 magId "2048651409" @default.

• next