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- W2048651807 abstract "In this study, we examined the effects of IL-18 deficiency on behaviors and gene expression profiles in 6 brain regions. IL-18(-/-) mice reduced depressive-like behavior and changed gene expressions predominantly in the amygdala compared with wild-type mice. Pathway analysis of the differentially expressed genes ranked behavior as the top-scored biological function. Of note, the absence of IL-18 decreased Avp, Hcrt, Oxt, and Pmch mRNA levels and the number of arginine vasopressin- and oxytocin-positive cells in the amygdala, but not in the hypothalamus. Our results suggest that IL-18-dependent vasopressinergic and oxytocinergic circuitry in the amygdala may regulate depressive-like behaviors in mice." @default.
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- W2048651807 date "2010-12-15" @default.
- W2048651807 modified "2023-09-23" @default.
- W2048651807 title "Interleukin-18 deficiency reduces neuropeptide gene expressions in the mouse amygdala related with behavioral change" @default.
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- W2048651807 doi "https://doi.org/10.1016/j.jneuroim.2010.07.024" @default.
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