FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048653022> ?p ?o ?g. }

• W2048653022 endingPage "e11616" @default.
• W2048653022 startingPage "e11616" @default.
• W2048653022 abstract "Multiple factors are involved in the variability of host's response to P. falciparum infection, like the intensity and seasonality of malaria transmission, the virulence of parasite and host characteristics like age or genetic make-up. Although admitted nowadays, the involvement of host genetic factors remains unclear. Discordant results exist, even concerning the best-known malaria resistance genes that determine the structure or function of red blood cells. Here we report on a genome-wide linkage and association study for P. falciparum infection intensity and mild malaria attack among a Senegalese population of children and young adults from 2 to 18 years old. A high density single nucleotide polymorphisms (SNP) genome scan (Affimetrix GeneChip Human Mapping 250K-nsp) was performed for 626 individuals: i.e. 249 parents and 377 children out of the 504 ones included in the follow-up. The population belongs to a unique ethnic group and was closely followed-up during 3 years. Genome-wide linkage analyses were performed on four clinical and parasitological phenotypes and association analyses using the family based association tests (FBAT) method were carried out in regions previously linked to malaria phenotypes in literature and in the regions for which we identified a linkage peak. Analyses revealed three strongly suggestive evidences for linkage: between mild malaria attack and both the 6p25.1 and the 12q22 regions (empirical p-value = 5×10−5 and 9×10−5 respectively), and between the 20p11q11 region and the prevalence of parasite density in asymptomatic children (empirical p-value = 1.5×10−4). Family based association analysis pointed out one significant association between the intensity of plasmodial infection and a polymorphism located in ARHGAP26 gene in the 5q31–q33 region (p-value = 3.7×10−5). This study identified three candidate regions, two of them containing genes that could point out new pathways implicated in the response to malaria infection. Furthermore, we detected one gene associated with malaria infection in the 5q31–q33 region." @default.
• W2048653022 created "2016-06-24" @default.
• W2048653022 creator A5000397434 @default.
• W2048653022 creator A5001734489 @default.
• W2048653022 creator A5016074838 @default.
• W2048653022 creator A5033254987 @default.
• W2048653022 creator A5050638269 @default.
• W2048653022 creator A5056052971 @default.
• W2048653022 creator A5068763196 @default.
• W2048653022 creator A5087944743 @default.
• W2048653022 creator A5091904403 @default.
• W2048653022 date "2010-07-15" @default.
• W2048653022 modified "2023-10-14" @default.
• W2048653022 title "Genome Wide Linkage Study, Using a 250K SNP Map, of Plasmodium falciparum Infection and Mild Malaria Attack in a Senegalese Population" @default.
• W2048653022 cites W1480160846 @default.
• W2048653022 cites W1492252078 @default.
• W2048653022 cites W1542598141 @default.
• W2048653022 cites W1675022656 @default.
• W2048653022 cites W1869259063 @default.
• W2048653022 cites W1947636523 @default.
• W2048653022 cites W1965923359 @default.
• W2048653022 cites W1969055690 @default.
• W2048653022 cites W1972906003 @default.
• W2048653022 cites W1975811950 @default.
• W2048653022 cites W1976741643 @default.
• W2048653022 cites W1996315565 @default.
• W2048653022 cites W2002036523 @default.
• W2048653022 cites W2002688528 @default.
• W2048653022 cites W2007374498 @default.
• W2048653022 cites W2008986700 @default.
• W2048653022 cites W2012117556 @default.
• W2048653022 cites W2013381485 @default.
• W2048653022 cites W2014095267 @default.
• W2048653022 cites W2017977290 @default.
• W2048653022 cites W2024722673 @default.
• W2048653022 cites W2026495245 @default.
• W2048653022 cites W2029021004 @default.
• W2048653022 cites W2030705868 @default.
• W2048653022 cites W2031155523 @default.
• W2048653022 cites W2031349038 @default.
• W2048653022 cites W2031497838 @default.
• W2048653022 cites W2044071049 @default.
• W2048653022 cites W2044720356 @default.
• W2048653022 cites W2046790669 @default.
• W2048653022 cites W2050437677 @default.
• W2048653022 cites W2051483473 @default.
• W2048653022 cites W2052436251 @default.
• W2048653022 cites W2053270368 @default.
• W2048653022 cites W2058527604 @default.
• W2048653022 cites W2060924805 @default.
• W2048653022 cites W2064306519 @default.
• W2048653022 cites W2065486243 @default.
• W2048653022 cites W2067428749 @default.
• W2048653022 cites W2068886946 @default.
• W2048653022 cites W2074122686 @default.
• W2048653022 cites W2075817888 @default.
• W2048653022 cites W2078578981 @default.
• W2048653022 cites W2079008364 @default.
• W2048653022 cites W2081485101 @default.
• W2048653022 cites W2088040652 @default.
• W2048653022 cites W2088717960 @default.
• W2048653022 cites W2097177690 @default.
• W2048653022 cites W2100828460 @default.
• W2048653022 cites W2103214447 @default.
• W2048653022 cites W2104731110 @default.
• W2048653022 cites W2105116084 @default.
• W2048653022 cites W2105306382 @default.
• W2048653022 cites W2105748597 @default.
• W2048653022 cites W2107755054 @default.
• W2048653022 cites W2115335486 @default.
• W2048653022 cites W2117793275 @default.
• W2048653022 cites W2119456039 @default.
• W2048653022 cites W2124508823 @default.
• W2048653022 cites W2127334295 @default.
• W2048653022 cites W2127574202 @default.
• W2048653022 cites W2130264648 @default.
• W2048653022 cites W2133682964 @default.
• W2048653022 cites W2139437304 @default.
• W2048653022 cites W2145883324 @default.
• W2048653022 cites W2146130945 @default.
• W2048653022 cites W2149080327 @default.
• W2048653022 cites W2150691880 @default.
• W2048653022 cites W2150907707 @default.
• W2048653022 cites W2151373350 @default.
• W2048653022 cites W2155635136 @default.
• W2048653022 cites W2160039183 @default.
• W2048653022 cites W2162530578 @default.
• W2048653022 cites W2164710696 @default.
• W2048653022 cites W2171717223 @default.
• W2048653022 cites W2189204704 @default.
• W2048653022 cites W2307091389 @default.
• W2048653022 cites W2315295323 @default.
• W2048653022 cites W4300951857 @default.
• W2048653022 doi "https://doi.org/10.1371/journal.pone.0011616" @default.
• W2048653022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2904701" @default.
• W2048653022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20657648" @default.
• W2048653022 hasPublicationYear "2010" @default.
• W2048653022 type Work @default.

• next