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• W2048653995 abstract "Variations in the matrix metalloproteinase (MMP)-9 gene are related to the presence and severity of atherosclerosis. The aim of this study was to determine the signaling pathways of MMP-9 in endothelial cells subjected to low fluid shear stress. We found that low fluid shear stress significantly increased MMP-9 expression, IκBα degradation, NF-κB DNA-binding activity and phosphorylation of MAPK in cultured human umbilical vein endothelial cells (HUVECs). Inhibition of NF-κB resulted in remarkable downregulation of stress-induced MMP-9 expression. Pretreatment of HUVECs with inhibitors of p38 mitogen-activating protein kinase (MAPK) and extracellular signal-regulated kinase1/2 (ERK1/2) also led to significant suppression of stress-induced MMP-9 expression and NF-κB DNA-binding activity. Similarly, addition of integrins inhibitor to HUVECs suppressed the stress-induced MMP-9 expression, IκBα degradation, NF-κB DNA-binding activity and the phosphorylation of p38 MAPK, ERK1/2. Our findings demonstrated that the shear stress-induced MMP-9 expression involved integrins-p38 MAPK or ERK1/2-NF-κB signaling pathways." @default.
• W2048653995 created "2016-06-24" @default.
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• W2048653995 date "2007-02-01" @default.
• W2048653995 modified "2023-10-01" @default.
• W2048653995 title "Involvement of integrins, MAPK, and NF-κB in regulation of the shear stress-induced MMP-9 expression in endothelial cells" @default.
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• W2048653995 doi "https://doi.org/10.1016/j.bbrc.2006.12.002" @default.
• W2048653995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17174275" @default.
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