FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048654101> ?p ?o ?g. }

• W2048654101 endingPage "23" @default.
• W2048654101 startingPage "10" @default.
• W2048654101 abstract "The response of differentiating mouse neural progenitor cells, migrating out from neurospheres, to conditions simulating ischemia (hypoxia and extracellular or intracellular acidosis) was studied. We show here, by using BCECF and single cell imaging to monitor intracellular pH (pHi), that two main populations can be distinguished by exposing migrating neural progenitor cells to low extracellular pH or by performing an acidifying ammonium prepulse. The cells dominating at the periphery of the neurosphere culture, which were positive for neuron specific markers MAP-2, calbindin and NeuN had lower initial resting pHi and could also easily be further acidified by lowering the extracellular pH. Moreover, in this population, a more profound acidification was seen when the cells were acidified using the ammonium prepulse technique. However, when the cell population was exposed to depolarizing potassium concentrations no alterations in pHi took place in this population. In contrast, depolarization caused an increase in pHi (by 0.5 pH units) in the cell population closer to the neurosphere body, which region was positive for the radial cell marker (GLAST). This cell population, having higher resting pHi (pH 6.9–7.1) also responded to acute hypoxia. During hypoxic treatment the resting pHi decreased by 0.1 pH units and recovered rapidly after reoxygenation. Our results show that migrating neural progenitor cells are highly sensitive to extracellular acidosis and that irreversible damage becomes evident at pH 6.2. Moreover, our results show that a response to acidosis clearly distinguishes two individual cell populations probably representing neuronal and radial cells." @default.
• W2048654101 created "2016-06-24" @default.
• W2048654101 creator A5000419083 @default.
• W2048654101 creator A5019389291 @default.
• W2048654101 creator A5023269872 @default.
• W2048654101 creator A5072315320 @default.
• W2048654101 date "2012-06-01" @default.
• W2048654101 modified "2023-09-27" @default.
• W2048654101 title "Effects of acute hypoxia/acidosis on intracellular pH in differentiating neural progenitor cells" @default.
• W2048654101 cites W132529730 @default.
• W2048654101 cites W1509835780 @default.
• W2048654101 cites W1525816166 @default.
• W2048654101 cites W1536629235 @default.
• W2048654101 cites W1563861455 @default.
• W2048654101 cites W1565217873 @default.
• W2048654101 cites W1569018919 @default.
• W2048654101 cites W1583701394 @default.
• W2048654101 cites W1635367091 @default.
• W2048654101 cites W1965191256 @default.
• W2048654101 cites W1968829729 @default.
• W2048654101 cites W1972399155 @default.
• W2048654101 cites W1983523125 @default.
• W2048654101 cites W1984883847 @default.
• W2048654101 cites W1985832800 @default.
• W2048654101 cites W1986418714 @default.
• W2048654101 cites W1987724728 @default.
• W2048654101 cites W1990667548 @default.
• W2048654101 cites W1992350473 @default.
• W2048654101 cites W1992910917 @default.
• W2048654101 cites W1993192425 @default.
• W2048654101 cites W1995923658 @default.
• W2048654101 cites W1996222694 @default.
• W2048654101 cites W2000225691 @default.
• W2048654101 cites W2005791783 @default.
• W2048654101 cites W2009667219 @default.
• W2048654101 cites W2011729164 @default.
• W2048654101 cites W2011781890 @default.
• W2048654101 cites W2013872458 @default.
• W2048654101 cites W2014081519 @default.
• W2048654101 cites W2022033428 @default.
• W2048654101 cites W2024102771 @default.
• W2048654101 cites W2028568974 @default.
• W2048654101 cites W2033275198 @default.
• W2048654101 cites W2033433537 @default.
• W2048654101 cites W2038825981 @default.
• W2048654101 cites W2039614265 @default.
• W2048654101 cites W2043471606 @default.
• W2048654101 cites W2048011585 @default.
• W2048654101 cites W2052875832 @default.
• W2048654101 cites W2058151497 @default.
• W2048654101 cites W2059709509 @default.
• W2048654101 cites W2060422389 @default.
• W2048654101 cites W2063489157 @default.
• W2048654101 cites W2068483310 @default.
• W2048654101 cites W2070021885 @default.
• W2048654101 cites W2071315089 @default.
• W2048654101 cites W2073793186 @default.
• W2048654101 cites W2076731666 @default.
• W2048654101 cites W2079356804 @default.
• W2048654101 cites W2079827300 @default.
• W2048654101 cites W2080203024 @default.
• W2048654101 cites W2086064342 @default.
• W2048654101 cites W2087302322 @default.
• W2048654101 cites W2089983241 @default.
• W2048654101 cites W2091311264 @default.
• W2048654101 cites W2092283978 @default.
• W2048654101 cites W2093829772 @default.
• W2048654101 cites W2097310850 @default.
• W2048654101 cites W2098015360 @default.
• W2048654101 cites W2103566186 @default.
• W2048654101 cites W2105166440 @default.
• W2048654101 cites W2118995823 @default.
• W2048654101 cites W2122507282 @default.
• W2048654101 cites W2124366134 @default.
• W2048654101 cites W2129561523 @default.
• W2048654101 cites W2130776893 @default.
• W2048654101 cites W2130929362 @default.
• W2048654101 cites W2132108823 @default.
• W2048654101 cites W2143785204 @default.
• W2048654101 cites W2144437938 @default.
• W2048654101 cites W2144522348 @default.
• W2048654101 cites W2148660598 @default.
• W2048654101 cites W2156071016 @default.
• W2048654101 cites W2170070762 @default.
• W2048654101 cites W2170768865 @default.
• W2048654101 cites W2184186366 @default.
• W2048654101 cites W2224803968 @default.
• W2048654101 cites W2329375265 @default.
• W2048654101 cites W2329486167 @default.
• W2048654101 cites W2425882825 @default.
• W2048654101 cites W2475105597 @default.
• W2048654101 cites W47558492 @default.
• W2048654101 doi "https://doi.org/10.1016/j.brainres.2012.04.043" @default.
• W2048654101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22608071" @default.
• W2048654101 hasPublicationYear "2012" @default.
• W2048654101 type Work @default.
• W2048654101 sameAs 2048654101 @default.
• W2048654101 citedByCount "12" @default.

• next