Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048654496> ?p ?o ?g. }
- W2048654496 endingPage "246" @default.
- W2048654496 startingPage "239" @default.
- W2048654496 abstract "Transforming growth factor-beta (TGFbeta)1 is thought to be implicated in breast cancer progression. However, data about the influence of TGFbeta1 on breast cancer development are conflicting. To clarify the clinical relevance of TGFbeta1, TGFbeta1 protein level has been measured by enzyme-immunoassay in 193 breast tumour samples. We found that 94.3% of patients expressed TGFbeta1 with a range of 0-684 pg mg(-1) protein. In the overall population, an increase of tumoral TGFbeta1 was observed in premenopausal patients when compared to postmenopausal subgroup (P=0.0006). When patients were subdivided according to nodal status, TGFbeta1 was correlated to type-1 plasminogen activator inhibitor in the node-negative subgroup (P=0.040). Multivariate analysis revealed that, after lymph node status (P=0.0002) and urokinase-type plasminogen activator (P=0.004), TGFbeta1 was an independent prognostic marker for DFS (P=0.005) in the overall population. In the node-negative population, TGFbeta1 was the prominent prognostic factor (P=0.010). In the same population, Kaplan-Meier curves demonstrated that high TGFbeta1 level was correlated with a shorter disease-free survival (P=0.020). These data suggest that the measurement of tumoral TGFbeta1 protein level, especially for node-negative patients, might help to identify a high-risk population early in tumour progression." @default.
- W2048654496 created "2016-06-24" @default.
- W2048654496 creator A5002668910 @default.
- W2048654496 creator A5023261733 @default.
- W2048654496 creator A5064835150 @default.
- W2048654496 creator A5066978149 @default.
- W2048654496 creator A5080041218 @default.
- W2048654496 creator A5080373640 @default.
- W2048654496 date "2006-01-01" @default.
- W2048654496 modified "2023-10-18" @default.
- W2048654496 title "Determination of TGFβ1 protein level in human primary breast cancers and its relationship with survival" @default.
- W2048654496 cites W1484024717 @default.
- W2048654496 cites W1495031987 @default.
- W2048654496 cites W1514512256 @default.
- W2048654496 cites W1520890133 @default.
- W2048654496 cites W1570640139 @default.
- W2048654496 cites W1636957566 @default.
- W2048654496 cites W1892136299 @default.
- W2048654496 cites W1906211198 @default.
- W2048654496 cites W19285171 @default.
- W2048654496 cites W1955500014 @default.
- W2048654496 cites W1965288495 @default.
- W2048654496 cites W1974571648 @default.
- W2048654496 cites W1980724611 @default.
- W2048654496 cites W1985723648 @default.
- W2048654496 cites W1997508119 @default.
- W2048654496 cites W2005514778 @default.
- W2048654496 cites W2009850312 @default.
- W2048654496 cites W2015353751 @default.
- W2048654496 cites W2041154504 @default.
- W2048654496 cites W2055245916 @default.
- W2048654496 cites W2069871721 @default.
- W2048654496 cites W2071919220 @default.
- W2048654496 cites W2073865988 @default.
- W2048654496 cites W2075362745 @default.
- W2048654496 cites W2083498974 @default.
- W2048654496 cites W2085827737 @default.
- W2048654496 cites W2089220956 @default.
- W2048654496 cites W2090133718 @default.
- W2048654496 cites W2091376484 @default.
- W2048654496 cites W2092356210 @default.
- W2048654496 cites W2094732490 @default.
- W2048654496 cites W2097829282 @default.
- W2048654496 cites W2105863720 @default.
- W2048654496 cites W2110405666 @default.
- W2048654496 cites W2129379081 @default.
- W2048654496 cites W2144545612 @default.
- W2048654496 cites W2146378617 @default.
- W2048654496 cites W2150776809 @default.
- W2048654496 cites W2156022038 @default.
- W2048654496 cites W2162305823 @default.
- W2048654496 cites W2163432183 @default.
- W2048654496 cites W2163504684 @default.
- W2048654496 cites W2166460162 @default.
- W2048654496 cites W2187173955 @default.
- W2048654496 cites W2213413145 @default.
- W2048654496 cites W2277013638 @default.
- W2048654496 cites W2340736065 @default.
- W2048654496 cites W4211166816 @default.
- W2048654496 cites W4238401957 @default.
- W2048654496 cites W946366983 @default.
- W2048654496 doi "https://doi.org/10.1038/sj.bjc.6602920" @default.
- W2048654496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2361106" @default.
- W2048654496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16404434" @default.
- W2048654496 hasPublicationYear "2006" @default.
- W2048654496 type Work @default.
- W2048654496 sameAs 2048654496 @default.
- W2048654496 citedByCount "76" @default.
- W2048654496 countsByYear W20486544962012 @default.
- W2048654496 countsByYear W20486544962013 @default.
- W2048654496 countsByYear W20486544962014 @default.
- W2048654496 countsByYear W20486544962015 @default.
- W2048654496 countsByYear W20486544962016 @default.
- W2048654496 countsByYear W20486544962017 @default.
- W2048654496 countsByYear W20486544962018 @default.
- W2048654496 countsByYear W20486544962019 @default.
- W2048654496 countsByYear W20486544962020 @default.
- W2048654496 countsByYear W20486544962021 @default.
- W2048654496 countsByYear W20486544962022 @default.
- W2048654496 countsByYear W20486544962023 @default.
- W2048654496 crossrefType "journal-article" @default.
- W2048654496 hasAuthorship W2048654496A5002668910 @default.
- W2048654496 hasAuthorship W2048654496A5023261733 @default.
- W2048654496 hasAuthorship W2048654496A5064835150 @default.
- W2048654496 hasAuthorship W2048654496A5066978149 @default.
- W2048654496 hasAuthorship W2048654496A5080041218 @default.
- W2048654496 hasAuthorship W2048654496A5080373640 @default.
- W2048654496 hasBestOaLocation W20486544961 @default.
- W2048654496 hasConcept C121608353 @default.
- W2048654496 hasConcept C126322002 @default.
- W2048654496 hasConcept C134018914 @default.
- W2048654496 hasConcept C143998085 @default.
- W2048654496 hasConcept C2778001805 @default.
- W2048654496 hasConcept C2779679481 @default.
- W2048654496 hasConcept C2780849966 @default.
- W2048654496 hasConcept C2908647359 @default.
- W2048654496 hasConcept C530470458 @default.
- W2048654496 hasConcept C71924100 @default.