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• W2048654501 abstract "To investigate the influence of the bortezomib (BTZ) on malignant glioma radiosensitivity in two xenograft models.For TCG3 and U87 models, we evaluated the antitumor activity of BTZ, radiotherapy, and BTZ plus radiothearapy according to two therapeutic schedules: a nonfractionated schedule corresponding to a single dose of treatment per week, and a fractionated schedule corresponding to the same weekly dose divided into 5 fractions. Treatments influence on proliferation and apoptosis indexes, cell cycle distribution, and nuclear factor-κB pathway were explored.The radiosensitizing properties of BTZ observed with the nonfractionated schedule were lost with the fractionated schedule. Bortezomib-mediated radiosensitization was associated with an increased apoptosis response and major changes in cell proliferation, but the nuclear factor-κB pathway was not involved. Most of the cellular effects induced by BTZ when tumors received a single irradiation were cancelled out if radiotherapy was fractionated.The influence of BTZ on glioma radiosensitivity seems to depend on the treatment fractionation schedule, emphasizing the need to clarify the mechanisms underlying BTZ's radiosensitizing effects before further clinical trials are initiated." @default.
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• W2048654501 date "2011-03-01" @default.
• W2048654501 modified "2023-10-17" @default.
• W2048654501 title "Radiosensitizing Properties of Bortezomib Depend on Therapeutic Schedule" @default.
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• W2048654501 doi "https://doi.org/10.1016/j.ijrobp.2010.09.051" @default.
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