FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048657237> ?p ?o ?g. }

• W2048657237 endingPage "520" @default.
• W2048657237 startingPage "510" @default.
• W2048657237 abstract "Somatic cells in vitro have a finite life expectancy before entering a state of senescence. If this state has an in vivo counterpart, it could contribute to organ aging. We have previously shown that human kidney cortex displays telomere shortening with age. In the present study, we evaluated the relationship between renal age in humans and a number of phenomena associated with cellular senescence in vitro.Human kidney specimens were obtained at 8 weeks to 88 years of age and were assessed for changes related to aging.We found that human kidneys expressed relatively constant levels of mRNAs for genes potentially related to senescence. Among the candidate genes surveyed, the cell cycle regulator p16INK4a emerged with the strongest association with renal aging for both mRNA and protein expression. Proliferation as measured by Ki-67 expression was inversely correlated with p16INK4a expression, compatible with a role for p16INK4a as an irreversible cell cycle inhibitor. Cyclooxygenase 1 and 2 (COX-1 and COX-2) mRNA expression was elevated in older kidneys, associated with increased protein expression. Comparison of gene expression with age-related histologic changes revealed that glomerulosclerosis correlated with p16INK4a and p53, whereas interstitial fibrosis and tubular atrophy were associated with p16INK4a, p53, COX-1, transforming growth factor-beta 1 (TGF-beta 1), and heat shock protein A5 (HSPA5).We conclude that some changes observed in cellular senescence in vitro do occur in human kidney with age, particularly in the renal cortex, in some cases correlating with histologic features. P16INK4a emerged with the most consistent correlations with age and histologic changes and inversely correlated with cell replication." @default.
• W2048657237 created "2016-06-24" @default.
• W2048657237 creator A5010106261 @default.
• W2048657237 creator A5020775252 @default.
• W2048657237 creator A5026501701 @default.
• W2048657237 creator A5038699745 @default.
• W2048657237 creator A5054458201 @default.
• W2048657237 creator A5089118254 @default.
• W2048657237 date "2004-02-01" @default.
• W2048657237 modified "2023-10-16" @default.
• W2048657237 title "Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney" @default.
• W2048657237 cites W1520658182 @default.
• W2048657237 cites W1555440776 @default.
• W2048657237 cites W1920602627 @default.
• W2048657237 cites W1966645907 @default.
• W2048657237 cites W1983269088 @default.
• W2048657237 cites W1983673827 @default.
• W2048657237 cites W1983751803 @default.
• W2048657237 cites W1990161819 @default.
• W2048657237 cites W1995791071 @default.
• W2048657237 cites W2004314923 @default.
• W2048657237 cites W2007789292 @default.
• W2048657237 cites W2014231393 @default.
• W2048657237 cites W2024619097 @default.
• W2048657237 cites W2029240083 @default.
• W2048657237 cites W2032389314 @default.
• W2048657237 cites W2038391869 @default.
• W2048657237 cites W2041615220 @default.
• W2048657237 cites W2043603162 @default.
• W2048657237 cites W2050364026 @default.
• W2048657237 cites W2050551830 @default.
• W2048657237 cites W2053300426 @default.
• W2048657237 cites W2060333964 @default.
• W2048657237 cites W2061912303 @default.
• W2048657237 cites W2066848701 @default.
• W2048657237 cites W2074832995 @default.
• W2048657237 cites W2075026875 @default.
• W2048657237 cites W2083462425 @default.
• W2048657237 cites W2084891010 @default.
• W2048657237 cites W2087404852 @default.
• W2048657237 cites W2088193327 @default.
• W2048657237 cites W2100189198 @default.
• W2048657237 cites W2108482850 @default.
• W2048657237 cites W2110480832 @default.
• W2048657237 cites W2111450457 @default.
• W2048657237 cites W2121529957 @default.
• W2048657237 cites W2123026240 @default.
• W2048657237 cites W2136840198 @default.
• W2048657237 cites W2164578725 @default.
• W2048657237 cites W2165460012 @default.
• W2048657237 cites W2170569465 @default.
• W2048657237 cites W2272191632 @default.
• W2048657237 cites W2286075367 @default.
• W2048657237 cites W2315355727 @default.
• W2048657237 cites W2885639847 @default.
• W2048657237 doi "https://doi.org/10.1111/j.1523-1755.2004.00438.x" @default.
• W2048657237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14717921" @default.
• W2048657237 hasPublicationYear "2004" @default.
• W2048657237 type Work @default.
• W2048657237 sameAs 2048657237 @default.
• W2048657237 citedByCount "289" @default.
• W2048657237 countsByYear W20486572372012 @default.
• W2048657237 countsByYear W20486572372013 @default.
• W2048657237 countsByYear W20486572372014 @default.
• W2048657237 countsByYear W20486572372015 @default.
• W2048657237 countsByYear W20486572372016 @default.
• W2048657237 countsByYear W20486572372017 @default.
• W2048657237 countsByYear W20486572372018 @default.
• W2048657237 countsByYear W20486572372019 @default.
• W2048657237 countsByYear W20486572372020 @default.
• W2048657237 countsByYear W20486572372021 @default.
• W2048657237 countsByYear W20486572372022 @default.
• W2048657237 countsByYear W20486572372023 @default.
• W2048657237 crossrefType "journal-article" @default.
• W2048657237 hasAuthorship W2048657237A5010106261 @default.
• W2048657237 hasAuthorship W2048657237A5020775252 @default.
• W2048657237 hasAuthorship W2048657237A5026501701 @default.
• W2048657237 hasAuthorship W2048657237A5038699745 @default.
• W2048657237 hasAuthorship W2048657237A5054458201 @default.
• W2048657237 hasAuthorship W2048657237A5089118254 @default.
• W2048657237 hasBestOaLocation W20486572371 @default.
• W2048657237 hasConcept C104317684 @default.
• W2048657237 hasConcept C126322002 @default.
• W2048657237 hasConcept C134018914 @default.
• W2048657237 hasConcept C1491633281 @default.
• W2048657237 hasConcept C150194340 @default.
• W2048657237 hasConcept C2777390665 @default.
• W2048657237 hasConcept C2779561371 @default.
• W2048657237 hasConcept C2780091579 @default.
• W2048657237 hasConcept C29537977 @default.
• W2048657237 hasConcept C502942594 @default.
• W2048657237 hasConcept C522857546 @default.
• W2048657237 hasConcept C54355233 @default.
• W2048657237 hasConcept C71924100 @default.
• W2048657237 hasConcept C86803240 @default.
• W2048657237 hasConcept C95444343 @default.
• W2048657237 hasConceptScore W2048657237C104317684 @default.
• W2048657237 hasConceptScore W2048657237C126322002 @default.

• next