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- W2048657791 abstract "ABSTRACT Under conditions of nutrient deprivation, Myxococcus xanthus undergoes a developmental process that results in the formation of a fruiting body containing environmentally resistant myxospores. We have shown that myxospores contain two copies of the genome, suggesting that cells must replicate the genome prior to or during development. To further investigate the role of DNA replication in development, a temperature-sensitive dnaB mutant, DnaB A116V , was isolated from M. xanthus . Unlike what happens in Escherichia coli dnaB mutants, where DNA replication immediately halts upon a shift to a nonpermissive temperature, growth and DNA replication of the M. xanthus mutant ceased after one cell doubling at a nonpermissive temperature, 37°C. We demonstrated that at the nonpermissive temperature the DnaB A116V mutant arrested as a population of 1 n cells, implying that these cells could complete one round of the cell cycle but did not initiate new rounds of DNA replication. In developmental assays, the DnaB A116V mutant was unable to develop into fruiting bodies and produced fewer myxospores than the wild type at the nonpermissive temperature. However, the mutant was able to undergo development when it was shifted to a permissive temperature, suggesting that cells had the capacity to undergo DNA replication during development and to allow the formation of myxospores." @default.
- W2048657791 created "2016-06-24" @default.
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- W2048657791 date "2007-12-15" @default.
- W2048657791 modified "2023-10-15" @default.
- W2048657791 title "The <i>Myxococcus xanthus</i> Developmental Program Can Be Delayed by Inhibition of DNA Replication" @default.
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- W2048657791 doi "https://doi.org/10.1128/jb.01361-07" @default.
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