Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048657965> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2048657965 endingPage "213" @default.
- W2048657965 startingPage "211" @default.
- W2048657965 abstract "It has been recently suggested that in Alzheimer disease (AD), the current available therapy with cholinesterase inhibitors (ChEIs) influences platelets amyloid precursor protein (APP) metabolism towards the nonamyloidogenic pathway. In order to investigate whether ChEIs may exert a protective role on vascular damage due to abeta deposition, several parameters of coagulation and fibrinolysis were assessed. Twenty patients with mild AD and 30 age-matched controls entered the study. All subjects performed a multidimensional neuropsychological assessment and a laboratory protocol. Individuals with vascular risk factors and systemic diseases were excluded. In mild AD patients, increased levels of markers of endothelial dysfunction, such as thrombomodulin (TM) and sE-selectin (sE-sel), were seen. After 1-month ChEIs treatment, a significant reduction of TM (p<0.05) and sE-sel (p<0.05) values towards the normal range was observed. These findings suggest that endothelial-related ChEIs action might contribute to the clinical efficacy in AD, slowing down pathology progression." @default.
- W2048657965 created "2016-06-24" @default.
- W2048657965 creator A5029825330 @default.
- W2048657965 creator A5031218930 @default.
- W2048657965 creator A5051875196 @default.
- W2048657965 creator A5067094608 @default.
- W2048657965 creator A5076308888 @default.
- W2048657965 creator A5076318425 @default.
- W2048657965 creator A5089967868 @default.
- W2048657965 creator A5090580473 @default.
- W2048657965 date "2005-03-01" @default.
- W2048657965 modified "2023-09-23" @default.
- W2048657965 title "Cholinesterase inhibitors exert a protective effect on endothelial damage in Alzheimer disease patients" @default.
- W2048657965 cites W1830318005 @default.
- W2048657965 cites W1985825991 @default.
- W2048657965 cites W1990427131 @default.
- W2048657965 cites W2000089342 @default.
- W2048657965 cites W2054879352 @default.
- W2048657965 cites W2092936307 @default.
- W2048657965 cites W2138979753 @default.
- W2048657965 cites W2147177629 @default.
- W2048657965 cites W2164504835 @default.
- W2048657965 cites W2333357401 @default.
- W2048657965 cites W2416577361 @default.
- W2048657965 cites W4302560171 @default.
- W2048657965 doi "https://doi.org/10.1016/j.jns.2004.11.030" @default.
- W2048657965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15760641" @default.
- W2048657965 hasPublicationYear "2005" @default.
- W2048657965 type Work @default.
- W2048657965 sameAs 2048657965 @default.
- W2048657965 citedByCount "17" @default.
- W2048657965 countsByYear W20486579652012 @default.
- W2048657965 countsByYear W20486579652014 @default.
- W2048657965 countsByYear W20486579652015 @default.
- W2048657965 countsByYear W20486579652016 @default.
- W2048657965 countsByYear W20486579652018 @default.
- W2048657965 countsByYear W20486579652021 @default.
- W2048657965 countsByYear W20486579652022 @default.
- W2048657965 crossrefType "journal-article" @default.
- W2048657965 hasAuthorship W2048657965A5029825330 @default.
- W2048657965 hasAuthorship W2048657965A5031218930 @default.
- W2048657965 hasAuthorship W2048657965A5051875196 @default.
- W2048657965 hasAuthorship W2048657965A5067094608 @default.
- W2048657965 hasAuthorship W2048657965A5076308888 @default.
- W2048657965 hasAuthorship W2048657965A5076318425 @default.
- W2048657965 hasAuthorship W2048657965A5089967868 @default.
- W2048657965 hasAuthorship W2048657965A5090580473 @default.
- W2048657965 hasConcept C126322002 @default.
- W2048657965 hasConcept C134018914 @default.
- W2048657965 hasConcept C201267052 @default.
- W2048657965 hasConcept C2776825266 @default.
- W2048657965 hasConcept C2777292125 @default.
- W2048657965 hasConcept C2779056891 @default.
- W2048657965 hasConcept C2779134260 @default.
- W2048657965 hasConcept C2779483572 @default.
- W2048657965 hasConcept C2780904820 @default.
- W2048657965 hasConcept C2780972559 @default.
- W2048657965 hasConcept C31896038 @default.
- W2048657965 hasConcept C502032728 @default.
- W2048657965 hasConcept C71924100 @default.
- W2048657965 hasConcept C89560881 @default.
- W2048657965 hasConceptScore W2048657965C126322002 @default.
- W2048657965 hasConceptScore W2048657965C134018914 @default.
- W2048657965 hasConceptScore W2048657965C201267052 @default.
- W2048657965 hasConceptScore W2048657965C2776825266 @default.
- W2048657965 hasConceptScore W2048657965C2777292125 @default.
- W2048657965 hasConceptScore W2048657965C2779056891 @default.
- W2048657965 hasConceptScore W2048657965C2779134260 @default.
- W2048657965 hasConceptScore W2048657965C2779483572 @default.
- W2048657965 hasConceptScore W2048657965C2780904820 @default.
- W2048657965 hasConceptScore W2048657965C2780972559 @default.
- W2048657965 hasConceptScore W2048657965C31896038 @default.
- W2048657965 hasConceptScore W2048657965C502032728 @default.
- W2048657965 hasConceptScore W2048657965C71924100 @default.
- W2048657965 hasConceptScore W2048657965C89560881 @default.
- W2048657965 hasLocation W20486579651 @default.
- W2048657965 hasLocation W20486579652 @default.
- W2048657965 hasOpenAccess W2048657965 @default.
- W2048657965 hasPrimaryLocation W20486579651 @default.
- W2048657965 hasRelatedWork W1996956475 @default.
- W2048657965 hasRelatedWork W2007654265 @default.
- W2048657965 hasRelatedWork W2037986700 @default.
- W2048657965 hasRelatedWork W2086916510 @default.
- W2048657965 hasRelatedWork W2124088010 @default.
- W2048657965 hasRelatedWork W2324549918 @default.
- W2048657965 hasRelatedWork W2467769383 @default.
- W2048657965 hasRelatedWork W4237892385 @default.
- W2048657965 hasRelatedWork W4312197339 @default.
- W2048657965 hasRelatedWork W76608054 @default.
- W2048657965 hasVolume "229-230" @default.
- W2048657965 isParatext "false" @default.
- W2048657965 isRetracted "false" @default.
- W2048657965 magId "2048657965" @default.
- W2048657965 workType "article" @default.