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• W2048658526 abstract "Abstract Ig determinants on leukemic B cells from 15 chronic lymphocytic leukemia (CLL) and 4 lymphosarcoma cell leukemia (LSL) patients were studied using goat antisera to individual heavy or light chains and a polyvalent goat anti-Ig. In 16 of 19 cases only one type of light chain was detected on the leukemic cells. Heavy chains on the cells varied from a single mu to combinations of up to four classes. Mu chain was the principal heavy chain on leukemic cells in 17 of 19 cases, followed, in the order of frequency, by delta ( 6 19 ), gamma ( 5 19 ), alpha ( 3 19 ), and epsilon ( 1 19 ) chains. To investigate the intrinsic or extrinsic origin of the surface Ig determinants, leukemic cells were cultured for 3 days after preexisting surface Ig had been labeled with the respective fluorescent antisera. The prelabeled Ig molecules were shed from cell surfaces by Day 3 of culture. Ig determinants reexpressed on the cell surface during the in vitro incubation were identified by restaining the antibody-prelabeled cells. With this technique, nearly all heavy chain determinants on leukemic B cells were proven to be generated from within the cell. Lack of a consistent association among antiserum reactivities and the absence of staining of cells by at least two of the seven goat antisera excluded the potential pitfalls of antiserum cross reactivities or nonspecific attachment of antisera as the cause of cell staining. The high proportion of cells carrying heavy-chain determinants indicated that the heavy chains were coexpressed on the same leukemic B cells. Serial studies in a single patient revealed appearance of endogenous alpha and delta chains on cells previously expressing gamma and mu chains. Our study demonstrates that a leukemic B cell can simultanously express multiple heavy-chain classes in different combinations, and that some of these heavy chains are generated during the course of the illness." @default.
• W2048658526 created "2016-06-24" @default.
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• W2048658526 date "1981-01-01" @default.
• W2048658526 modified "2023-09-24" @default.
• W2048658526 title "Coexpression of multiple immunoglobulin (Ig) heavy chain classes on human leukemic B lymphocytes (B cells)" @default.
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• W2048658526 doi "https://doi.org/10.1016/0090-1229(81)90013-1" @default.
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