FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048659048> ?p ?o ?g. }

• W2048659048 endingPage "223" @default.
• W2048659048 startingPage "218" @default.
• W2048659048 abstract "A 37-year old male patient presented with frequent angina attacks (up to 40/day) largely resistant to classical vasodilator therapy. The patient showed severe coronary and peripheral endothelial dysfunction, increased platelet aggregation and increased platelet-derived superoxide production. The endothelial nitric oxide synthase (eNOS)-inhibitor NG-nitro-l-arginine methyl ester (L-NAME) reduced superoxide formation in platelets identifying “uncoupled” eNOS as a superoxide source. Oral l-arginine normalized coronary and peripheral endothelial dysfunction and reduced platelet aggregation and eNOS-derived superoxide production. Plasma concentrations of the endogenous NOS inhibitor asymmetric dimethyl-l-arginine (ADMA), representing an independent risk factor for cardiovascular disease, were normal in the patient. However, immediately after oral administration of cationic amino acid (CAA), plasma ADMA levels rose markedly, demonstrating increased ADMA efflux from intracellular stores. ADMA efflux from mononuclear cells of the patient was accelerated by CAA, but not neutral amino acids (NAA) demonstrating impairment of y+LAT (whose expression was found reduced in these cells). These data suggest that impairment of y+LAT may cause intracellular (endothelial) ADMA accumulation leading to systemic endothelial dysfunction. This may represent a novel mechanism underlying vasospastic angina and vascular dysfunction in general. Moreover, these new findings contribute to the understanding of the l-arginine paradox, the improvement of eNOS activity by oral l-arginine despite sufficient cellular l-arginine levels to ensure proper function of this enzyme." @default.
• W2048659048 created "2016-06-24" @default.
• W2048659048 creator A5014783499 @default.
• W2048659048 creator A5030999965 @default.
• W2048659048 creator A5035254382 @default.
• W2048659048 creator A5039361810 @default.
• W2048659048 creator A5042303952 @default.
• W2048659048 creator A5054447927 @default.
• W2048659048 creator A5064206049 @default.
• W2048659048 creator A5068677676 @default.
• W2048659048 creator A5088335421 @default.
• W2048659048 date "2012-06-01" @default.
• W2048659048 modified "2023-09-30" @default.
• W2048659048 title "Impairment of the extrusion transporter for asymmetric dimethyl-l-arginine: A novel mechanism underlying vasospastic angina" @default.
• W2048659048 cites W1978675432 @default.
• W2048659048 cites W2002965551 @default.
• W2048659048 cites W2010970668 @default.
• W2048659048 cites W2020086048 @default.
• W2048659048 cites W2021456091 @default.
• W2048659048 cites W2042782418 @default.
• W2048659048 cites W2047861478 @default.
• W2048659048 cites W2053824404 @default.
• W2048659048 cites W2055148238 @default.
• W2048659048 cites W2066568065 @default.
• W2048659048 cites W2082748378 @default.
• W2048659048 cites W2086100475 @default.
• W2048659048 cites W2121605783 @default.
• W2048659048 cites W2133662129 @default.
• W2048659048 cites W2169502743 @default.
• W2048659048 cites W2169890089 @default.
• W2048659048 cites W4242045705 @default.
• W2048659048 cites W4245288524 @default.
• W2048659048 doi "https://doi.org/10.1016/j.bbrc.2012.05.044" @default.
• W2048659048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22609206" @default.
• W2048659048 hasPublicationYear "2012" @default.
• W2048659048 type Work @default.
• W2048659048 sameAs 2048659048 @default.
• W2048659048 citedByCount "25" @default.
• W2048659048 countsByYear W20486590482013 @default.
• W2048659048 countsByYear W20486590482014 @default.
• W2048659048 countsByYear W20486590482015 @default.
• W2048659048 countsByYear W20486590482016 @default.
• W2048659048 countsByYear W20486590482017 @default.
• W2048659048 countsByYear W20486590482018 @default.
• W2048659048 countsByYear W20486590482019 @default.
• W2048659048 countsByYear W20486590482020 @default.
• W2048659048 countsByYear W20486590482021 @default.
• W2048659048 countsByYear W20486590482022 @default.
• W2048659048 countsByYear W20486590482023 @default.
• W2048659048 crossrefType "journal-article" @default.
• W2048659048 hasAuthorship W2048659048A5014783499 @default.
• W2048659048 hasAuthorship W2048659048A5030999965 @default.
• W2048659048 hasAuthorship W2048659048A5035254382 @default.
• W2048659048 hasAuthorship W2048659048A5039361810 @default.
• W2048659048 hasAuthorship W2048659048A5042303952 @default.
• W2048659048 hasAuthorship W2048659048A5054447927 @default.
• W2048659048 hasAuthorship W2048659048A5064206049 @default.
• W2048659048 hasAuthorship W2048659048A5068677676 @default.
• W2048659048 hasAuthorship W2048659048A5088335421 @default.
• W2048659048 hasConcept C120770815 @default.
• W2048659048 hasConcept C126322002 @default.
• W2048659048 hasConcept C134018914 @default.
• W2048659048 hasConcept C181199279 @default.
• W2048659048 hasConcept C185592680 @default.
• W2048659048 hasConcept C2776992346 @default.
• W2048659048 hasConcept C2777468819 @default.
• W2048659048 hasConcept C2777622882 @default.
• W2048659048 hasConcept C2778326061 @default.
• W2048659048 hasConcept C2780795997 @default.
• W2048659048 hasConcept C2780972559 @default.
• W2048659048 hasConcept C3018697912 @default.
• W2048659048 hasConcept C515207424 @default.
• W2048659048 hasConcept C519581460 @default.
• W2048659048 hasConcept C55493867 @default.
• W2048659048 hasConcept C71924100 @default.
• W2048659048 hasConcept C89560881 @default.
• W2048659048 hasConcept C98274493 @default.
• W2048659048 hasConceptScore W2048659048C120770815 @default.
• W2048659048 hasConceptScore W2048659048C126322002 @default.
• W2048659048 hasConceptScore W2048659048C134018914 @default.
• W2048659048 hasConceptScore W2048659048C181199279 @default.
• W2048659048 hasConceptScore W2048659048C185592680 @default.
• W2048659048 hasConceptScore W2048659048C2776992346 @default.
• W2048659048 hasConceptScore W2048659048C2777468819 @default.
• W2048659048 hasConceptScore W2048659048C2777622882 @default.
• W2048659048 hasConceptScore W2048659048C2778326061 @default.
• W2048659048 hasConceptScore W2048659048C2780795997 @default.
• W2048659048 hasConceptScore W2048659048C2780972559 @default.
• W2048659048 hasConceptScore W2048659048C3018697912 @default.
• W2048659048 hasConceptScore W2048659048C515207424 @default.
• W2048659048 hasConceptScore W2048659048C519581460 @default.
• W2048659048 hasConceptScore W2048659048C55493867 @default.
• W2048659048 hasConceptScore W2048659048C71924100 @default.
• W2048659048 hasConceptScore W2048659048C89560881 @default.
• W2048659048 hasConceptScore W2048659048C98274493 @default.
• W2048659048 hasFunder F4320317480 @default.
• W2048659048 hasFunder F4320321114 @default.
• W2048659048 hasIssue "2" @default.

• next