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• W2048659985 abstract "Voltage-gated Kv1.5 channels are expressed in a wide variety of tissues including cardiac myocytes, smooth muscle and tumor cells. Kv1.5 channel activity is modified by N-cadherin, which in turn binds the multifunctional oncogenic protein β-catenin. The present experiments explored the effect of β-catenin on Kv1.5 channel activity. To this end, Kv1.5 was expressed in Xenopus oocytes with or without β-catenin and the voltage-gated Kv current determined by dual electrode voltage clamp. As a result, expression of β-catenin significantly increased the voltage-gated Kv current at positive potentials. The stimulating effect of β-catenin on Kv1.5 was not dependent on the stimulation of transcription since it was observed even in the presence of the transcription inhibitor actinomycin D. Specific antibody binding to surface Kv1.5 in Xenopus oocytes revealed that β-catenin enhances the membrane abundance of Kv1.5. Further experiments with brefeldin A showed that β-catenin fosters the insertion of Kv1.5 into rather than delaying the retrieval from the plasma membrane. According to electrophysiological recordings with mutant β-catenin, the effect on Kv1.5 requires the same protein domains that are required for association of β-catenin with cadherin. The experiments disclose a completely novel function of β-catenin, i.e. the regulation of Kv1.5 channel activity." @default.
• W2048659985 created "2016-06-24" @default.
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• W2048659985 date "2012-01-01" @default.
• W2048659985 modified "2023-09-23" @default.
• W2048659985 title "Activation of voltage gated K+ channel Kv1.5 by β-catenin" @default.
• W2048659985 cites W1505834333 @default.
• W2048659985 cites W1554815317 @default.
• W2048659985 cites W1562370090 @default.
• W2048659985 cites W1914025411 @default.
• W2048659985 cites W1964212105 @default.
• W2048659985 cites W1969864825 @default.
• W2048659985 cites W1973461639 @default.
• W2048659985 cites W1976518797 @default.
• W2048659985 cites W1977129233 @default.
• W2048659985 cites W1977999098 @default.
• W2048659985 cites W1978214583 @default.
• W2048659985 cites W1978509102 @default.
• W2048659985 cites W1979292172 @default.
• W2048659985 cites W1984009107 @default.
• W2048659985 cites W1985326986 @default.
• W2048659985 cites W1994064741 @default.
• W2048659985 cites W1997045129 @default.
• W2048659985 cites W2002404925 @default.
• W2048659985 cites W2003197155 @default.
• W2048659985 cites W2007616017 @default.
• W2048659985 cites W2009959265 @default.
• W2048659985 cites W2011396210 @default.
• W2048659985 cites W2011467092 @default.
• W2048659985 cites W2016688369 @default.
• W2048659985 cites W2020905073 @default.
• W2048659985 cites W2022469082 @default.
• W2048659985 cites W2022920350 @default.
• W2048659985 cites W2023255331 @default.
• W2048659985 cites W2024142249 @default.
• W2048659985 cites W2024538494 @default.
• W2048659985 cites W2024622742 @default.
• W2048659985 cites W2025058252 @default.
• W2048659985 cites W2025853036 @default.
• W2048659985 cites W2030587074 @default.
• W2048659985 cites W2034521811 @default.
• W2048659985 cites W2038357734 @default.
• W2048659985 cites W2067889812 @default.
• W2048659985 cites W2082319583 @default.
• W2048659985 cites W2084028077 @default.
• W2048659985 cites W2084240121 @default.
• W2048659985 cites W2084731764 @default.
• W2048659985 cites W2086873110 @default.
• W2048659985 cites W2087211815 @default.
• W2048659985 cites W2088180630 @default.
• W2048659985 cites W2088419773 @default.
• W2048659985 cites W2100078256 @default.
• W2048659985 cites W2103447315 @default.
• W2048659985 cites W2104646410 @default.
• W2048659985 cites W2109825385 @default.
• W2048659985 cites W2110063504 @default.
• W2048659985 cites W2110838173 @default.
• W2048659985 cites W2111123535 @default.
• W2048659985 cites W2112709575 @default.
• W2048659985 cites W2117287580 @default.
• W2048659985 cites W2117988622 @default.
• W2048659985 cites W2119564057 @default.
• W2048659985 cites W2120609231 @default.
• W2048659985 cites W2130473918 @default.
• W2048659985 cites W2130517208 @default.
• W2048659985 cites W2131150732 @default.
• W2048659985 cites W2136775298 @default.
• W2048659985 cites W2140020611 @default.
• W2048659985 cites W2151260260 @default.
• W2048659985 cites W2151638020 @default.
• W2048659985 cites W2158360036 @default.
• W2048659985 cites W2159167870 @default.
• W2048659985 cites W2160020345 @default.
• W2048659985 cites W2166113945 @default.
• W2048659985 cites W2170250797 @default.
• W2048659985 cites W2186800727 @default.
• W2048659985 cites W2281290620 @default.
• W2048659985 cites W2327772540 @default.
• W2048659985 cites W2328025308 @default.
• W2048659985 cites W2474502530 @default.
• W2048659985 cites W2531345437 @default.
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• W2048659985 doi "https://doi.org/10.1016/j.bbrc.2011.11.156" @default.
• W2048659985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22166221" @default.
• W2048659985 hasPublicationYear "2012" @default.
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